ENSG00000180182

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324817 ENSG00000180182 HEK293_OSMI2_2hA HEK293_TMG_2hB MED14 protein_coding protein_coding 20.96005 15.73715 26.4982 0.27626 0.3895133 0.7513479 2.3507080 2.6125249 2.583175 0.46761866 0.09130010 -0.01623685 0.11970833 0.16510000 0.09750000 -0.06760000 9.444059e-02 2.288912e-61 FALSE TRUE
ENST00000416199 ENSG00000180182 HEK293_OSMI2_2hA HEK293_TMG_2hB MED14 protein_coding protein_coding 20.96005 15.73715 26.4982 0.27626 0.3895133 0.7513479 0.5713905 2.5365052 0.000000 0.58175758 0.00000000 -7.99237486 0.03563750 0.16006667 0.00000000 -0.16006667 6.347380e-20 2.288912e-61 FALSE TRUE
ENST00000433003 ENSG00000180182 HEK293_OSMI2_2hA HEK293_TMG_2hB MED14 protein_coding protein_coding 20.96005 15.73715 26.4982 0.27626 0.3895133 0.7513479 2.1943066 2.9581693 1.201430 0.08206022 0.27575996 -1.29286222 0.12372917 0.18813333 0.04516667 -0.14296667 5.560490e-08 2.288912e-61 FALSE TRUE
MSTRG.34112.4 ENSG00000180182 HEK293_OSMI2_2hA HEK293_TMG_2hB MED14 protein_coding   20.96005 15.73715 26.4982 0.27626 0.3895133 0.7513479 3.5901584 0.0000000 6.897197 0.00000000 0.07016439 9.43195648 0.14074167 0.00000000 0.26033333 0.26033333 2.288912e-61 2.288912e-61 FALSE TRUE
MSTRG.34112.5 ENSG00000180182 HEK293_OSMI2_2hA HEK293_TMG_2hB MED14 protein_coding   20.96005 15.73715 26.4982 0.27626 0.3895133 0.7513479 6.3199914 4.7949456 9.080986 0.51357017 0.41012009 0.91991671 0.30334167 0.30510000 0.34330000 0.03820000 7.250633e-01 2.288912e-61 FALSE TRUE
MSTRG.34112.6 ENSG00000180182 HEK293_OSMI2_2hA HEK293_TMG_2hB MED14 protein_coding   20.96005 15.73715 26.4982 0.27626 0.3895133 0.7513479 1.1739470 1.6227743 1.598295 0.16546799 0.79997731 -0.02179329 0.06023333 0.10310000 0.05946667 -0.04363333 7.088597e-01 2.288912e-61 FALSE TRUE
MSTRG.34112.7 ENSG00000180182 HEK293_OSMI2_2hA HEK293_TMG_2hB MED14 protein_coding   20.96005 15.73715 26.4982 0.27626 0.3895133 0.7513479 0.9738695 0.6662183 0.000000 0.66621827 0.00000000 -6.07941709 0.05003333 0.04346667 0.00000000 -0.04346667 7.442678e-01 2.288912e-61 FALSE TRUE
MSTRG.34112.8 ENSG00000180182 HEK293_OSMI2_2hA HEK293_TMG_2hB MED14 protein_coding   20.96005 15.73715 26.4982 0.27626 0.3895133 0.7513479 2.3843618 0.0000000 2.543901 0.00000000 0.40617188 7.99655859 0.09944167 0.00000000 0.09646667 0.09646667 2.144781e-14 2.288912e-61 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180182 E001 1.2671751 0.4863264431 4.129316e-01 5.564905e-01 X 40648305 40649542 1238 - 0.235 0.458 1.383
ENSG00000180182 E002 3.4684974 0.1701933484 5.235503e-01 6.572208e-01 X 40649543 40649605 63 - 0.557 0.782 0.954
ENSG00000180182 E003 25.7725950 0.0322537356 1.991490e-03 7.200308e-03 X 40649606 40649672 67 - 1.235 1.613 1.309
ENSG00000180182 E004 99.6694093 0.0323219507 5.330058e-07 4.690030e-06 X 40649673 40650021 349 - 1.705 2.239 1.797
ENSG00000180182 E005 185.3084115 0.0177471832 9.934881e-05 5.188085e-04 X 40650022 40650420 399 - 2.110 2.424 1.048
ENSG00000180182 E006 356.0592239 0.0073749582 7.087695e-06 4.874369e-05 X 40650421 40651475 1055 - 2.437 2.669 0.774
ENSG00000180182 E007 254.0737234 0.0028638645 1.503954e-20 1.025998e-18 X 40651476 40651879 404 - 2.231 2.572 1.140
ENSG00000180182 E008 23.6130371 0.0269427978 5.158198e-06 3.660219e-05 X 40653872 40654363 492 - 1.111 1.620 1.775
ENSG00000180182 E009 215.3942793 0.0003531145 2.011191e-13 5.475913e-12 X 40654364 40654556 193 - 2.229 2.443 0.715
ENSG00000180182 E010 181.7189984 0.0008990415 2.331506e-07 2.207270e-06 X 40654935 40655060 126 - 2.169 2.351 0.609
ENSG00000180182 E011 153.3620135 0.0014154224 1.067982e-05 7.051650e-05 X 40659227 40659334 108 - 2.097 2.274 0.591
ENSG00000180182 E012 224.8596545 0.0002419821 5.499276e-10 8.558460e-09 X 40659428 40659607 180 - 2.262 2.442 0.599
ENSG00000180182 E013 0.8407440 0.0165219141 8.632323e-01 9.158081e-01 X 40659608 40659819 212 - 0.234 0.277 0.326
ENSG00000180182 E014 237.9397493 0.0008240009 1.008286e-05 6.693182e-05 X 40662925 40663160 236 - 2.306 2.452 0.487
ENSG00000180182 E015 164.0570914 0.0003410914 2.495023e-02 6.177057e-02 X 40664307 40664489 183 - 2.168 2.262 0.314
ENSG00000180182 E016 112.0452073 0.0002617871 4.121311e-02 9.327193e-02 X 40666720 40666851 132 - 2.001 2.100 0.331
ENSG00000180182 E017 124.0364444 0.0002516269 1.516934e-01 2.639624e-01 X 40671861 40671972 112 - 2.055 2.131 0.253
ENSG00000180182 E018 126.8709799 0.0029515715 7.534800e-01 8.393971e-01 X 40675221 40675361 141 - 2.080 2.121 0.138
ENSG00000180182 E019 223.8870896 0.0001801939 1.178583e-02 3.302113e-02 X 40679864 40680133 270 - 2.353 2.320 -0.109
ENSG00000180182 E020 171.5400071 0.0002595211 4.660263e-02 1.031237e-01 X 40680758 40680910 153 - 2.234 2.207 -0.091
ENSG00000180182 E021 0.1451727 0.0432670966 8.288992e-01   X 40681848 40681851 4 - 0.093 0.000 -9.569
ENSG00000180182 E022 129.9717599 0.0002771605 2.931860e-02 7.062164e-02 X 40681852 40681943 92 - 2.121 2.079 -0.139
ENSG00000180182 E023 160.3090938 0.0022908144 8.018832e-02 1.598409e-01 X 40682603 40682749 147 - 2.209 2.173 -0.120
ENSG00000180182 E024 151.2053123 0.0096715986 1.942306e-01 3.190623e-01 X 40682836 40682996 161 - 2.186 2.144 -0.143
ENSG00000180182 E025 84.0056641 0.0214753376 4.077194e-01 5.513016e-01 X 40688454 40688530 77 - 1.929 1.894 -0.117
ENSG00000180182 E026 122.8440316 0.0037193695 6.426620e-05 3.523176e-04 X 40692183 40692317 135 - 2.134 1.982 -0.508
ENSG00000180182 E027 151.0785289 0.0048430558 6.166216e-05 3.395747e-04 X 40692708 40692902 195 - 2.225 2.071 -0.513
ENSG00000180182 E028 132.4941152 0.0008162866 1.003798e-08 1.236936e-07 X 40697024 40697183 160 - 2.173 2.000 -0.579
ENSG00000180182 E029 101.4924859 0.0007689971 4.401273e-06 3.172303e-05 X 40701165 40701243 79 - 2.054 1.905 -0.502
ENSG00000180182 E030 126.4505366 0.0010468097 1.199512e-10 2.089883e-09 X 40703444 40703569 126 - 2.165 1.955 -0.702
ENSG00000180182 E031 131.9970354 0.0005198518 6.525163e-14 1.903854e-12 X 40709348 40709459 112 - 2.187 1.955 -0.777
ENSG00000180182 E032 118.7469796 0.0010707829 4.029460e-08 4.428666e-07 X 40709979 40710129 151 - 2.126 1.947 -0.601
ENSG00000180182 E033 106.4244908 0.0130657319 2.560832e-03 8.944851e-03 X 40711169 40711301 133 - 2.078 1.907 -0.575
ENSG00000180182 E034 106.9883927 0.0036483595 9.857404e-08 1.002069e-06 X 40712186 40712293 108 - 2.097 1.873 -0.750
ENSG00000180182 E035 130.5182046 0.0019431892 5.389122e-11 9.946930e-10 X 40712914 40713042 129 - 2.184 1.952 -0.778
ENSG00000180182 E036 101.9032798 0.0006142232 9.436314e-13 2.326326e-11 X 40713778 40713831 54 - 2.085 1.832 -0.851
ENSG00000180182 E037 97.7012747 0.0004008448 4.613324e-13 1.195914e-11 X 40713832 40713877 46 - 2.067 1.808 -0.869
ENSG00000180182 E038 90.3752415 0.0012779517 7.514554e-11 1.351828e-09 X 40713878 40713907 30 - 2.032 1.774 -0.866
ENSG00000180182 E039 133.2737989 0.0039425493 1.874794e-09 2.640307e-08 X 40714537 40714710 174 - 2.197 1.952 -0.821
ENSG00000180182 E040 2.3229224 0.0061829909 6.180720e-01 7.357976e-01 X 40714711 40715051 341 - 0.462 0.566 0.495
ENSG00000180182 E041 6.4601047 0.0033684844 4.034569e-02 9.165922e-02 X 40715118 40715220 103 - 0.946 0.700 -0.966
ENSG00000180182 E042 0.1482932 0.0414634662 2.830357e-01   X 40726455 40726527 73 - 0.000 0.160 11.108
ENSG00000180182 E043 0.4407149 0.0214965243 9.371780e-01 9.645116e-01 X 40726528 40726745 218 - 0.169 0.160 -0.093
ENSG00000180182 E044 79.1419061 0.0019047509 5.432745e-08 5.809863e-07 X 40726746 40726851 106 - 1.970 1.740 -0.775
ENSG00000180182 E045 46.7281145 0.0005755324 7.239536e-07 6.198347e-06 X 40729319 40729345 27 - 1.747 1.496 -0.855
ENSG00000180182 E046 0.3729606 0.0303138938 6.804549e-01 7.843301e-01 X 40729346 40729540 195 - 0.093 0.160 0.911
ENSG00000180182 E047 52.3444213 0.0069944002 2.431555e-05 1.479432e-04 X 40735198 40735542 345 - 1.796 1.540 -0.871
ENSG00000180182 E048 20.7183806 0.0048801720 1.683402e-03 6.230157e-03 X 40735722 40735857 136 - 1.406 1.158 -0.871
ENSG00000180182 E049 9.0130407 0.0018650913 8.542550e-01 9.098368e-01 X 40735858 40735960 103 - 0.969 1.016 0.172