ENSG00000180104

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315013 ENSG00000180104 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC3 protein_coding protein_coding 27.21484 33.25655 20.70953 1.076423 0.4984003 -0.6830814 10.949543 17.43188 5.039827 0.3963096 1.470290 -1.7882500 0.3815875 0.5253667 0.2402667 -0.2851 0.01609953 0.0004879706 FALSE TRUE
ENST00000512944 ENSG00000180104 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC3 protein_coding protein_coding 27.21484 33.25655 20.70953 1.076423 0.4984003 -0.6830814 9.673887 10.94974 9.695953 0.9285767 1.518992 -0.1752713 0.3690208 0.3281333 0.4722333 0.1441 0.37346509 0.0004879706 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000180104 E001 0.000000       5 443175 443175 1 +      
ENSG00000180104 E002 3.625029 0.0644093144 9.531645e-01 9.747067e-01 5 443176 443232 57 + 0.621 0.633 0.053
ENSG00000180104 E003 27.835773 0.0054513464 1.140322e-01 2.113988e-01 5 443233 443267 35 + 1.498 1.386 -0.386
ENSG00000180104 E004 39.730147 0.0054849409 1.034631e-02 2.961872e-02 5 443268 443290 23 + 1.680 1.517 -0.554
ENSG00000180104 E005 2.474451 0.0065069740 3.907749e-02 8.933836e-02 5 444926 445064 139 + 0.707 0.380 -1.548
ENSG00000180104 E006 0.806200 0.1232712080 7.833500e-01 8.609479e-01 5 446149 446149 1 + 0.281 0.230 -0.384
ENSG00000180104 E007 154.936402 0.0035352370 3.802560e-02 8.739762e-02 5 446150 446349 200 + 2.207 2.129 -0.259
ENSG00000180104 E008 3.384005 0.0082957631 1.918122e-01 3.160314e-01 5 447018 447314 297 + 0.744 0.552 -0.827
ENSG00000180104 E009 223.919837 0.0001785060 6.576038e-03 2.012423e-02 5 447533 447752 220 + 2.356 2.297 -0.195
ENSG00000180104 E010 102.979717 0.0005180655 1.334076e-05 8.609371e-05 5 453370 453396 27 + 2.081 1.931 -0.504
ENSG00000180104 E011 516.676947 0.0020916827 5.231834e-04 2.246448e-03 5 453397 454051 655 + 2.730 2.651 -0.263
ENSG00000180104 E012 181.032381 0.0002065841 1.405891e-01 2.488367e-01 5 456889 457005 117 + 2.247 2.214 -0.108
ENSG00000180104 E013 87.524279 0.0003172086 2.863729e-01 4.267683e-01 5 457006 457006 1 + 1.934 1.900 -0.115
ENSG00000180104 E014 11.945873 0.0135444670 3.544796e-06 2.611210e-05 5 457007 457899 893 + 1.349 0.852 -1.807
ENSG00000180104 E015 194.237628 0.0002531509 9.347837e-02 1.805555e-01 5 457900 458025 126 + 2.279 2.242 -0.124
ENSG00000180104 E016 145.594550 0.0052466222 8.166533e-01 8.840008e-01 5 459359 459459 101 + 2.116 2.131 0.052
ENSG00000180104 E017 5.252369 0.0083274575 2.927777e-02 7.054032e-02 5 459460 459580 121 + 0.941 0.653 -1.143
ENSG00000180104 E018 16.590448 0.0010945741 4.134541e-07 3.718202e-06 5 461630 461959 330 + 1.451 1.042 -1.445
ENSG00000180104 E019 177.335969 0.0002221074 2.476768e-01 3.832120e-01 5 461960 462070 111 + 2.184 2.225 0.138
ENSG00000180104 E020 221.014137 0.0002310730 5.380759e-01 6.695448e-01 5 462157 462307 151 + 2.292 2.316 0.080
ENSG00000180104 E021 9.542169 0.0020825610 6.960369e-03 2.112022e-02 5 462308 462529 222 + 1.165 0.890 -1.013
ENSG00000180104 E022 224.053710 0.0003463300 1.997375e-02 5.142747e-02 5 464290 464412 123 + 2.266 2.336 0.232
ENSG00000180104 E023 15.075797 0.0012016742 1.305420e-03 4.995010e-03 5 464413 464788 376 + 1.341 1.069 -0.964
ENSG00000180104 E024 13.461949 0.0012939531 1.193625e-02 3.337848e-02 5 464789 465110 322 + 1.272 1.051 -0.791
ENSG00000180104 E025 263.879638 0.0003563140 1.469901e-10 2.522129e-09 5 465111 465272 162 + 2.262 2.432 0.566
ENSG00000180104 E026 259.108874 0.0005203525 3.975532e-14 1.196430e-12 5 465718 465845 128 + 2.224 2.432 0.697
ENSG00000180104 E027 2.367888 0.0064196756 3.843754e-02 8.817005e-02 5 465846 466078 233 + 0.707 0.380 -1.550
ENSG00000180104 E028 427.661327 0.0040139132 9.556319e-12 1.998252e-10 5 466727 467290 564 + 2.413 2.654 0.804
ENSG00000180104 E029 36.736257 0.0059502708 5.358857e-04 2.294125e-03 5 467291 468609 1319 + 1.684 1.455 -0.780
ENSG00000180104 E030 12.057212 0.0016471420 1.804528e-01 3.017560e-01 5 468870 468942 73 + 1.165 1.042 -0.445
ENSG00000180104 E031 6.038058 0.0118412407 2.730471e-02 6.661253e-02 5 469438 469547 110 + 0.984 0.697 -1.119
ENSG00000180104 E032 6.752443 0.0035800194 2.240011e-02 5.650794e-02 5 469631 469789 159 + 1.023 0.753 -1.034
ENSG00000180104 E033 15.101603 0.0011816466 2.408715e-02 5.999129e-02 5 469790 469855 66 + 1.293 1.102 -0.677
ENSG00000180104 E034 24.231973 0.0008018345 7.670349e-03 2.295289e-02 5 469856 469987 132 + 1.485 1.303 -0.629
ENSG00000180104 E035 11.757257 0.0016802798 8.201814e-04 3.331423e-03 5 471099 471122 24 + 1.272 0.961 -1.121
ENSG00000180104 E036 73.866670 0.0053659576 2.948665e-03 1.011362e-02 5 471123 471937 815 + 1.941 1.786 -0.521