ENSG00000179981

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322038 ENSG00000179981 HEK293_OSMI2_2hA HEK293_TMG_2hB TSHZ1 protein_coding protein_coding 4.6809 4.717932 4.675886 0.1113643 0.07730474 -0.01288752 1.033736 0.7067831 1.406499 0.2485976 0.26322511 0.9827212 0.2112750 0.1481333 0.3026000 0.1544667 0.2502600001 0.0004123664 FALSE TRUE
ENST00000560918 ENSG00000179981 HEK293_OSMI2_2hA HEK293_TMG_2hB TSHZ1 protein_coding protein_coding 4.6809 4.717932 4.675886 0.1113643 0.07730474 -0.01288752 2.534742 3.3778503 1.557372 0.1154910 0.29779593 -1.1120228 0.5461500 0.7179000 0.3312000 -0.3867000 0.0004123664 0.0004123664 FALSE TRUE
ENST00000580243 ENSG00000179981 HEK293_OSMI2_2hA HEK293_TMG_2hB TSHZ1 protein_coding protein_coding 4.6809 4.717932 4.675886 0.1113643 0.07730474 -0.01288752 1.063214 0.6147877 1.665459 0.1649624 0.09113071 1.4231187 0.2305042 0.1300667 0.3559333 0.2258667 0.0019906261 0.0004123664 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179981 E001 0.1515154 0.0428743796 4.643241e-01   18 75210631 75210692 62 + 0.124 0.000 -9.479
ENSG00000179981 E002 0.0000000       18 75210755 75210787 33 +      
ENSG00000179981 E003 0.1515154 0.0428743796 4.643241e-01   18 75210788 75210796 9 + 0.124 0.000 -10.556
ENSG00000179981 E004 2.6216988 0.0067345347 9.070677e-01 9.450053e-01 18 75210797 75210830 34 + 0.562 0.551 -0.052
ENSG00000179981 E005 27.8996089 0.0007777450 1.301108e-04 6.593139e-04 18 75210831 75211243 413 + 1.570 1.332 -0.820
ENSG00000179981 E006 8.3065858 0.0291597199 2.479174e-03 8.701497e-03 18 75211244 75211293 50 + 1.143 0.740 -1.523
ENSG00000179981 E007 20.7206258 0.0015091395 1.382162e-08 1.660619e-07 18 75211294 75211916 623 + 1.516 1.086 -1.506
ENSG00000179981 E008 0.0000000       18 75221058 75221154 97 +      
ENSG00000179981 E009 0.0000000       18 75244576 75244622 47 +      
ENSG00000179981 E010 0.0000000       18 75245228 75245400 173 +      
ENSG00000179981 E011 0.8877700 0.0264630629 2.108462e-02 5.377586e-02 18 75282864 75285447 2584 + 0.000 0.414 11.953
ENSG00000179981 E012 580.8480469 0.0007586712 4.208032e-13 1.095806e-11 18 75285448 75289950 4503 + 2.736 2.781 0.148