ENSG00000179889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396410 ENSG00000179889 HEK293_OSMI2_2hA HEK293_TMG_2hB PDXDC1 protein_coding protein_coding 43.68004 38.72621 46.13232 1.269475 0.6148543 0.2524078 18.066662 17.200705 20.335174 1.8283076 1.1527868 0.2413804 0.4125625 0.4428 0.4405000 -0.002300000 1.0000000000 6.635252e-05 FALSE TRUE
ENST00000535621 ENSG00000179889 HEK293_OSMI2_2hA HEK293_TMG_2hB PDXDC1 protein_coding protein_coding 43.68004 38.72621 46.13232 1.269475 0.6148543 0.2524078 10.322797 6.264966 12.266345 0.4869524 0.2489719 0.9682015 0.2322625 0.1621 0.2661000 0.104000000 0.0005772275 6.635252e-05 FALSE TRUE
ENST00000569715 ENSG00000179889 HEK293_OSMI2_2hA HEK293_TMG_2hB PDXDC1 protein_coding protein_coding 43.68004 38.72621 46.13232 1.269475 0.6148543 0.2524078 6.547572 5.513525 6.399103 1.2607796 0.4786343 0.2145332 0.1491292 0.1405 0.1386667 -0.001833333 1.0000000000 6.635252e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179889 E001 0.5838113 0.3934025454 5.507359e-01 6.803335e-01 16 14974591 14974736 146 + 0.277 0.129 -1.364
ENSG00000179889 E002 1.0340911 0.0116401305 6.355780e-02 1.326215e-01 16 14974737 14974802 66 + 0.446 0.132 -2.343
ENSG00000179889 E003 0.7437457 0.0153787590 2.017961e-01 3.284280e-01 16 14974803 14974804 2 + 0.342 0.132 -1.758
ENSG00000179889 E004 0.4031496 0.0257901402 1.751913e-01 2.949297e-01 16 14974805 14974886 82 + 0.000 0.233 13.445
ENSG00000179889 E005 0.9180607 0.0141949183 1.412997e-01 2.498231e-01 16 14974887 14974973 87 + 0.114 0.383 2.245
ENSG00000179889 E006 1.6661746 0.1809409132 4.155651e-01 5.589413e-01 16 14975012 14975025 14 + 0.491 0.320 -0.946
ENSG00000179889 E007 2.6594912 0.3441834339 7.040162e-01 8.026199e-01 16 14975026 14975030 5 + 0.602 0.506 -0.443
ENSG00000179889 E008 20.0333663 0.0245882234 1.619278e-01 2.776352e-01 16 14975031 14975079 49 + 1.376 1.264 -0.390
ENSG00000179889 E009 31.7860268 0.0105866945 2.424371e-03 8.535326e-03 16 14975080 14975088 9 + 1.607 1.400 -0.711
ENSG00000179889 E010 52.8081384 0.0018464492 4.745440e-05 2.688747e-04 16 14975089 14975104 16 + 1.811 1.632 -0.608
ENSG00000179889 E011 66.1233727 0.0003741850 7.724449e-06 5.265615e-05 16 14975105 14975122 18 + 1.903 1.742 -0.544
ENSG00000179889 E012 67.4746581 0.0003749332 4.565199e-05 2.597395e-04 16 14975123 14975128 6 + 1.903 1.761 -0.479
ENSG00000179889 E013 94.8825563 0.0005443791 1.334743e-06 1.078997e-05 16 14975129 14975151 23 + 2.049 1.901 -0.497
ENSG00000179889 E014 190.1919337 0.0021952103 1.080323e-04 5.590657e-04 16 14975152 14975220 69 + 2.329 2.230 -0.329
ENSG00000179889 E015 1.3390940 0.2490268275 2.417276e-01 3.762258e-01 16 14976763 14976904 142 + 0.204 0.491 1.803
ENSG00000179889 E016 0.2987644 0.0274350403 2.273669e-01   16 14997748 14997752 5 + 0.204 0.000 -13.521
ENSG00000179889 E017 118.0458877 0.0100957186 5.031746e-03 1.601911e-02 16 14997753 14997756 4 + 2.137 2.007 -0.436
ENSG00000179889 E018 202.4415133 0.0064565393 2.028405e-03 7.314930e-03 16 14997757 14997826 70 + 2.360 2.252 -0.362
ENSG00000179889 E019 113.6488504 0.0055460531 6.863526e-04 2.849558e-03 16 14998340 14998342 3 + 2.123 1.990 -0.446
ENSG00000179889 E020 202.4155652 0.0054261419 9.747711e-03 2.814238e-02 16 14998343 14998405 63 + 2.348 2.269 -0.264
ENSG00000179889 E021 118.9418796 0.0038846274 5.326901e-01 6.650097e-01 16 15001776 15001788 13 + 2.077 2.082 0.017
ENSG00000179889 E022 180.9227945 0.0004306213 1.817219e-05 1.138297e-04 16 15001789 15001856 68 + 2.301 2.217 -0.281
ENSG00000179889 E023 0.9201516 0.0143461233 9.170368e-01 9.515925e-01 16 15001857 15001887 31 + 0.278 0.314 0.241
ENSG00000179889 E024 263.8670984 0.0027962272 1.186030e-04 6.074668e-04 16 15004187 15004333 147 + 2.469 2.377 -0.308
ENSG00000179889 E025 296.5340887 0.0002130363 1.578824e-06 1.255524e-05 16 15006394 15006583 190 + 2.509 2.442 -0.222
ENSG00000179889 E026 184.4338428 0.0008917106 1.229307e-02 3.423724e-02 16 15008779 15008847 69 + 2.290 2.252 -0.128
ENSG00000179889 E027 1.7994930 0.0089313211 1.104349e-01 2.061739e-01 16 15009311 15009680 370 + 0.567 0.314 -1.343
ENSG00000179889 E028 148.6765566 0.0028723267 1.927099e-01 3.171686e-01 16 15009681 15009759 79 + 2.185 2.170 -0.051
ENSG00000179889 E029 118.9667770 0.0002733651 5.071085e-01 6.427217e-01 16 15016129 15016213 85 + 2.076 2.089 0.043
ENSG00000179889 E030 114.7396099 0.0002580959 1.808551e-01 3.022766e-01 16 15017120 15017168 49 + 2.069 2.059 -0.034
ENSG00000179889 E031 241.3301427 0.0009432632 7.478976e-02 1.511908e-01 16 15017321 15017422 102 + 2.391 2.378 -0.046
ENSG00000179889 E032 349.3940848 0.0002851145 3.656893e-01 5.099875e-01 16 15018840 15018965 126 + 2.539 2.555 0.055
ENSG00000179889 E033 216.2799591 0.0009731784 7.875541e-01 8.639194e-01 16 15022704 15022754 51 + 2.318 2.360 0.141
ENSG00000179889 E034 20.8267994 0.0008705057 2.141178e-01 3.433784e-01 16 15025224 15026642 1419 + 1.364 1.304 -0.211
ENSG00000179889 E035 249.3184779 0.0001837404 3.462460e-01 4.903952e-01 16 15026643 15026706 64 + 2.373 2.428 0.186
ENSG00000179889 E036 308.1169949 0.0001636627 9.201441e-01 9.535555e-01 16 15028878 15028966 89 + 2.475 2.507 0.108
ENSG00000179889 E037 43.2338321 0.0283967658 1.154664e-02 3.245803e-02 16 15028967 15029805 839 + 1.482 1.765 0.963
ENSG00000179889 E038 300.8394559 0.0003801353 3.647181e-02 8.447926e-02 16 15029951 15030056 106 + 2.486 2.474 -0.040
ENSG00000179889 E039 314.2517709 0.0001491029 3.241105e-02 7.665254e-02 16 15031735 15031906 172 + 2.504 2.495 -0.029
ENSG00000179889 E040 11.9588313 0.0092816518 6.318737e-05 3.470661e-04 16 15031907 15032860 954 + 1.271 0.867 -1.471
ENSG00000179889 E041 276.5303734 0.0001565002 9.099017e-01 9.467241e-01 16 15032861 15032979 119 + 2.425 2.462 0.123
ENSG00000179889 E042 305.5603842 0.0001417712 4.155098e-01 5.588920e-01 16 15033278 15033399 122 + 2.479 2.496 0.059
ENSG00000179889 E043 8.8980253 0.0019254796 8.522352e-05 4.527069e-04 16 15034092 15034285 194 + 1.160 0.748 -1.549
ENSG00000179889 E044 246.0251003 0.0001725486 3.877895e-01 5.319274e-01 16 15034286 15034378 93 + 2.366 2.420 0.180
ENSG00000179889 E045 242.2809961 0.0002008622 5.883626e-01 7.115587e-01 16 15034457 15034553 97 + 2.362 2.409 0.156
ENSG00000179889 E046 216.0292740 0.0014393362 4.149336e-03 1.356151e-02 16 15035449 15035553 105 + 2.272 2.391 0.398
ENSG00000179889 E047 7.1305137 0.0431806473 6.630522e-01 7.712106e-01 16 15035951 15036015 65 + 0.862 0.971 0.411
ENSG00000179889 E048 1781.2187500 0.0027130435 1.587287e-16 6.670515e-15 16 15036016 15038332 2317 + 3.132 3.343 0.701
ENSG00000179889 E049 35.8854905 0.0101075282 1.263014e-01 2.290012e-01 16 15138879 15139339 461 + 1.481 1.628 0.499