ENSG00000179820

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000391768 ENSG00000179820 HEK293_OSMI2_2hA HEK293_TMG_2hB MYADM protein_coding protein_coding 12.35256 14.07646 14.65407 0.9431648 0.4035692 0.0579768 2.253262 1.943188 3.517787 0.3944652 0.5545698 0.8529325 0.1829000 0.1360667 0.2383333 0.10226667 0.09065848 0.02731819 FALSE TRUE
ENST00000391770 ENSG00000179820 HEK293_OSMI2_2hA HEK293_TMG_2hB MYADM protein_coding protein_coding 12.35256 14.07646 14.65407 0.9431648 0.4035692 0.0579768 5.830251 8.191111 6.442657 0.6668228 0.4761470 -0.3459262 0.4635542 0.5814000 0.4395333 -0.14186667 0.02731819 0.02731819 FALSE TRUE
ENST00000448420 ENSG00000179820 HEK293_OSMI2_2hA HEK293_TMG_2hB MYADM protein_coding protein_coding 12.35256 14.07646 14.65407 0.9431648 0.4035692 0.0579768 3.698898 3.214757 4.266197 0.3167033 0.4415434 0.4071378 0.3033417 0.2333333 0.2930000 0.05966667 0.64644093 0.02731819 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179820 E001 0.0000000       19 53864763 53864891 129 +      
ENSG00000179820 E002 0.0000000       19 53865510 53865583 74 +      
ENSG00000179820 E003 0.0000000       19 53865584 53865728 145 +      
ENSG00000179820 E004 0.0000000       19 53865934 53866140 207 +      
ENSG00000179820 E005 0.0000000       19 53866153 53866157 5 +      
ENSG00000179820 E006 0.3299976 0.0277827961 2.015965e-01   19 53866158 53866417 260 + 0.000 0.224 10.361
ENSG00000179820 E007 21.2057079 0.0066451847 2.593027e-01 3.966914e-01 19 53867883 53867943 61 + 1.366 1.309 -0.197
ENSG00000179820 E008 0.6590396 0.0233648190 3.119436e-01 4.544577e-01 19 53868578 53868587 10 + 0.288 0.127 -1.471
ENSG00000179820 E009 1.2406844 0.1768155053 3.730667e-01 5.175064e-01 19 53868588 53868659 72 + 0.211 0.435 1.459
ENSG00000179820 E010 0.9986021 0.0128271609 4.117089e-01 5.552575e-01 19 53869406 53869438 33 + 0.353 0.225 -0.887
ENSG00000179820 E011 3.3311887 0.1791438512 5.822933e-01 7.066629e-01 19 53869439 53869598 160 + 0.649 0.587 -0.269
ENSG00000179820 E012 13.8919719 0.0012810885 3.834905e-02 8.800651e-02 19 53869599 53869689 91 + 1.238 1.085 -0.544
ENSG00000179820 E013 41.9198319 0.0005303900 2.619025e-06 1.986891e-05 19 53869690 53869753 64 + 1.729 1.511 -0.741
ENSG00000179820 E014 64.1148286 0.0004170695 1.831270e-04 8.912514e-04 19 53869754 53869764 11 + 1.871 1.744 -0.427
ENSG00000179820 E015 104.8383225 0.0003077041 9.528378e-06 6.364806e-05 19 53869765 53869838 74 + 2.076 1.962 -0.380
ENSG00000179820 E016 0.0000000       19 53872712 53872787 76 +      
ENSG00000179820 E017 1123.8310550 0.0015459020 8.135055e-11 1.457226e-09 19 53873528 53876435 2908 + 3.006 3.084 0.258