ENSG00000179603

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339582 ENSG00000179603 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM8 protein_coding protein_coding 0.609206 0.3936085 1.110901 0.06068753 0.1188165 1.47363 0.206577239 0.186064658 0.26119861 0.094651343 0.09230446 0.4680203 0.477462500 0.55346667 0.25083333 -0.30263333 0.63890964 0.01196786 FALSE TRUE
ENST00000341617 ENSG00000179603 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM8 protein_coding nonsense_mediated_decay 0.609206 0.3936085 1.110901 0.06068753 0.1188165 1.47363 0.022569045 0.104881424 0.04415639 0.104881424 0.04415639 -1.0849422 0.039375000 0.20590000 0.04316667 -0.16273333 0.83413503 0.01196786 TRUE TRUE
ENST00000358373 ENSG00000179603 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM8 protein_coding protein_coding 0.609206 0.3936085 1.110901 0.06068753 0.1188165 1.47363 0.045882703 0.028344660 0.14641505 0.015952157 0.03734249 2.0282818 0.064941667 0.08756667 0.13150000 0.04393333 0.69982741 0.01196786 FALSE TRUE
ENST00000423518 ENSG00000179603 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM8 protein_coding processed_transcript 0.609206 0.3936085 1.110901 0.06068753 0.1188165 1.47363 0.008609894 0.000000000 0.06887915 0.000000000 0.06887915 2.9796441 0.006395833 0.00000000 0.05116667 0.05116667 0.95885590 0.01196786   FALSE
ENST00000457830 ENSG00000179603 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM8 protein_coding protein_coding 0.609206 0.3936085 1.110901 0.06068753 0.1188165 1.47363 0.129568194 0.000000000 0.33878138 0.000000000 0.09465652 5.1242511 0.153295833 0.00000000 0.32170000 0.32170000 0.01196786 0.01196786 FALSE TRUE
ENST00000472701 ENSG00000179603 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM8 protein_coding nonsense_mediated_decay 0.609206 0.3936085 1.110901 0.06068753 0.1188165 1.47363 0.027353366 0.009413104 0.10151284 0.009413104 0.02791261 2.5221071 0.040004167 0.02563333 0.09026667 0.06463333 0.44443470 0.01196786 TRUE TRUE
ENST00000489939 ENSG00000179603 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM8 protein_coding processed_transcript 0.609206 0.3936085 1.110901 0.06068753 0.1188165 1.47363 0.036653558 0.000000000 0.14995764 0.000000000 0.14995764 3.9996180 0.030050000 0.00000000 0.11140000 0.11140000 0.96083389 0.01196786   FALSE
ENST00000495315 ENSG00000179603 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM8 protein_coding processed_transcript 0.609206 0.3936085 1.110901 0.06068753 0.1188165 1.47363 0.055696144 0.064904658 0.00000000 0.064904658 0.00000000 -2.9050554 0.101475000 0.12743333 0.00000000 -0.12743333 0.52508264 0.01196786   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179603 E001 0.1451727 0.043646705 0.946960781   7 126438598 126438614 17 - 0.093 0.000 -8.285
ENSG00000179603 E002 0.0000000       7 126438615 126438627 13 -      
ENSG00000179603 E003 1.1289244 0.456880539 0.365501536 0.50981946 7 126438628 126438691 64 - 0.234 0.440 1.296
ENSG00000179603 E004 1.1289244 0.456880539 0.365501536 0.50981946 7 126438692 126438692 1 - 0.234 0.440 1.296
ENSG00000179603 E005 7.7151659 0.031593627 0.115699908 0.21381679 7 126438693 126439076 384 - 0.844 1.032 0.708
ENSG00000179603 E006 2.9087082 0.006302879 0.185922452 0.30864668 7 126439077 126439118 42 - 0.499 0.697 0.883
ENSG00000179603 E007 2.0585010 0.077497984 0.464841237 0.60452408 7 126439119 126439168 50 - 0.427 0.561 0.655
ENSG00000179603 E008 0.0000000       7 126445236 126445453 218 -      
ENSG00000179603 E009 0.6600838 0.020444784 0.535055271 0.66699973 7 126446071 126446125 55 - 0.170 0.275 0.884
ENSG00000179603 E010 3.1237366 0.010138941 0.070278700 0.14382570 7 126446126 126446372 247 - 0.499 0.767 1.169
ENSG00000179603 E011 0.0000000       7 126447136 126447188 53 -      
ENSG00000179603 E012 0.0000000       7 126465231 126465299 69 -      
ENSG00000179603 E013 3.3161504 0.022675391 0.076064149 0.15321444 7 126532952 126533050 99 - 0.499 0.768 1.174
ENSG00000179603 E014 9.9758486 0.006070140 0.019688020 0.05082629 7 126533051 126533778 728 - 0.926 1.154 0.836
ENSG00000179603 E015 3.0270145 0.077388926 0.961040199 0.97946129 7 126533779 126533887 109 - 0.588 0.569 -0.086
ENSG00000179603 E016 0.0000000       7 126533888 126533905 18 -      
ENSG00000179603 E017 2.4357186 0.006576867 0.042798634 0.09618117 7 126609362 126609493 132 - 0.639 0.275 -1.924
ENSG00000179603 E018 1.4747940 0.009676551 0.006809013 0.02072604 7 126609494 126609498 5 - 0.531 0.000 -12.917
ENSG00000179603 E019 0.0000000       7 126701757 126701827 71 -      
ENSG00000179603 E020 2.1444428 0.006920838 0.014595589 0.03958385 7 126769865 126769920 56 - 0.614 0.159 -2.816
ENSG00000179603 E021 3.3246476 0.004951787 0.546288417 0.67649024 7 126769921 126770065 145 - 0.662 0.563 -0.438
ENSG00000179603 E022 3.9909723 0.004197037 0.584236324 0.70819594 7 126902542 126902679 138 - 0.662 0.734 0.298
ENSG00000179603 E023 5.0530598 0.003496886 0.114539302 0.21217187 7 126903972 126904108 137 - 0.684 0.882 0.790
ENSG00000179603 E024 2.3896325 0.007313600 0.912318991 0.94843467 7 126904109 126904126 18 - 0.531 0.507 -0.116
ENSG00000179603 E025 3.4417196 0.005117639 0.766634838 0.84908308 7 126904548 126904683 136 - 0.662 0.612 -0.217
ENSG00000179603 E026 0.0000000       7 127075965 127076236 272 -      
ENSG00000179603 E027 0.0000000       7 127080693 127080877 185 -      
ENSG00000179603 E028 0.0000000       7 127082104 127082174 71 -      
ENSG00000179603 E029 0.0000000       7 127084289 127084415 127 -      
ENSG00000179603 E030 0.1451727 0.043646705 0.946960781   7 127084691 127084789 99 - 0.093 0.000 -10.164
ENSG00000179603 E031 0.0000000       7 127090909 127090918 10 -      
ENSG00000179603 E032 0.0000000       7 127090919 127090922 4 -      
ENSG00000179603 E033 0.0000000       7 127090923 127091013 91 -      
ENSG00000179603 E034 0.0000000       7 127095665 127095810 146 -      
ENSG00000179603 E035 0.0000000       7 127105296 127105370 75 -      
ENSG00000179603 E036 4.6628163 0.003804368 0.019026419 0.04939252 7 127106496 127106652 157 - 0.859 0.506 -1.496
ENSG00000179603 E037 3.1202574 0.038491794 0.011288401 0.03184884 7 127106653 127106712 60 - 0.745 0.274 -2.372
ENSG00000179603 E038 0.0000000       7 127111041 127111186 146 -      
ENSG00000179603 E039 0.0000000       7 127112169 127112286 118 -      
ENSG00000179603 E040 0.0000000       7 127112287 127112320 34 -      
ENSG00000179603 E041 0.0000000       7 127118221 127118272 52 -      
ENSG00000179603 E042 12.0869623 0.001749248 0.191099722 0.31512519 7 127242695 127243142 448 - 1.159 1.030 -0.465
ENSG00000179603 E043 4.1006732 0.004059470 0.318240530 0.46120909 7 127243143 127243219 77 - 0.763 0.612 -0.632
ENSG00000179603 E044 5.3926274 0.003511587 0.428399422 0.57117611 7 127243220 127243515 296 - 0.844 0.734 -0.439
ENSG00000179603 E045 0.0000000       7 127250849 127251026 178 -      
ENSG00000179603 E046 0.0000000       7 127251165 127251219 55 -      
ENSG00000179603 E047 0.6192988 0.019960393 0.689459713 0.79134327 7 127252129 127252381 253 - 0.235 0.159 -0.701
ENSG00000179603 E048 2.2852724 0.006903275 0.904612789 0.94327442 7 127252797 127252941 145 - 0.531 0.506 -0.118
ENSG00000179603 E049 0.7374030 0.015921033 0.475051396 0.61381163 7 127252942 127253093 152 - 0.292 0.159 -1.118