ENSG00000179456

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358704 ENSG00000179456 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB18 protein_coding protein_coding 11.62788 8.304549 14.70471 1.370945 0.4106846 0.8235491 1.0118489 0.2660114 1.6737556 0.13305936 0.07385379 2.608883 0.08157500 0.02943333 0.114266667 0.08483333 0.0549260306 0.0001136662 FALSE  
ENST00000622512 ENSG00000179456 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB18 protein_coding protein_coding 11.62788 8.304549 14.70471 1.370945 0.4106846 0.8235491 4.5452801 4.2659616 4.6528494 1.63229960 1.25313489 0.124963 0.37672500 0.47956667 0.313366667 -0.16620000 0.4871586190 0.0001136662 FALSE  
ENST00000696615 ENSG00000179456 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB18 protein_coding protein_coding 11.62788 8.304549 14.70471 1.370945 0.4106846 0.8235491 0.7807775 1.1697545 0.1213786 1.16975451 0.12137865 -3.166684 0.08970417 0.15263333 0.008233333 -0.14440000 0.9577191246 0.0001136662 FALSE  
ENST00000696616 ENSG00000179456 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB18 protein_coding protein_coding 11.62788 8.304549 14.70471 1.370945 0.4106846 0.8235491 1.4000664 0.6023860 1.7212844 0.14649247 0.62592217 1.499330 0.12527083 0.08176667 0.118133333 0.03636667 0.7936004236 0.0001136662 FALSE  
ENST00000696617 ENSG00000179456 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB18 protein_coding nonsense_mediated_decay 11.62788 8.304549 14.70471 1.370945 0.4106846 0.8235491 1.0114619 0.1253498 1.2078361 0.03781467 0.16569420 3.169556 0.08914167 0.01450000 0.082800000 0.06830000 0.0001136662 0.0001136662 FALSE  
MSTRG.3383.2 ENSG00000179456 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB18 protein_coding   11.62788 8.304549 14.70471 1.370945 0.4106846 0.8235491 2.8784426 1.8750859 5.3276052 0.95972937 0.21868193 1.501562 0.23755833 0.24206667 0.363166667 0.12110000 0.7324701895 0.0001136662 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179456 E001 0.1515154 0.0445140999 7.833328e-01   1 244048547 244048586 40 + 0.100 0.000 -7.902
ENSG00000179456 E002 2.7514600 0.0673231018 2.087954e-01 3.370718e-01 1 244048862 244048938 77 + 0.665 0.421 -1.148
ENSG00000179456 E003 18.0763296 0.0010028502 2.164431e-03 7.733634e-03 1 244048939 244048993 55 + 1.375 1.124 -0.882
ENSG00000179456 E004 6.3627703 0.0462410706 1.666766e-03 6.175585e-03 1 244049799 244049921 123 + 1.024 0.484 -2.226
ENSG00000179456 E005 9.8633206 0.0017442747 4.032767e-05 2.322387e-04 1 244051283 244051444 162 + 1.181 0.708 -1.788
ENSG00000179456 E006 7.1642880 0.0217310296 2.947664e-05 1.757438e-04 1 244052236 244052277 42 + 1.082 0.423 -2.749
ENSG00000179456 E007 9.6282701 0.0017276408 2.661980e-04 1.241957e-03 1 244053100 244053200 101 + 1.159 0.742 -1.570
ENSG00000179456 E008 245.5826979 0.0002010427 3.131334e-24 3.185938e-22 1 244053788 244054475 688 + 2.472 2.256 -0.722
ENSG00000179456 E009 46.8084712 0.0005334967 4.202373e-03 1.370931e-02 1 244054476 244054587 112 + 1.740 1.597 -0.483
ENSG00000179456 E010 860.3228005 0.0001800097 7.498067e-44 3.235732e-41 1 244054588 244057476 2889 + 2.893 2.989 0.321