ENSG00000179364

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325438 ENSG00000179364 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS2 protein_coding protein_coding 22.87726 30.25554 17.22869 3.418814 0.5267221 -0.8120256 0.449402 0.01836364 0.9382056 0.01836364 0.37980209 5.0630852 0.02209167 0.0005666667 0.05330000 0.052733333 6.466078e-06 4.510868e-13 FALSE  
ENST00000548796 ENSG00000179364 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS2 protein_coding retained_intron 22.87726 30.25554 17.22869 3.418814 0.5267221 -0.8120256 1.331723 1.03931797 1.1612409 0.24771574 0.10799356 0.1585860 0.06043750 0.0333666667 0.06726667 0.033900000 1.539027e-02 4.510868e-13 FALSE  
ENST00000549030 ENSG00000179364 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS2 protein_coding retained_intron 22.87726 30.25554 17.22869 3.418814 0.5267221 -0.8120256 2.396159 1.49236069 2.0462368 0.19594618 0.11468637 0.4527752 0.11049583 0.0491000000 0.11860000 0.069500000 6.776907e-08 4.510868e-13    
ENST00000552138 ENSG00000179364 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS2 protein_coding retained_intron 22.87726 30.25554 17.22869 3.418814 0.5267221 -0.8120256 2.539428 4.09393770 0.6336101 0.54985426 0.08443495 -2.6727500 0.10571250 0.1346000000 0.03656667 -0.098033333 4.510868e-13 4.510868e-13 FALSE  
MSTRG.10296.13 ENSG00000179364 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS2 protein_coding   22.87726 30.25554 17.22869 3.418814 0.5267221 -0.8120256 5.015654 5.47304484 5.0964818 1.46532705 0.29088467 -0.1026476 0.22969583 0.1738000000 0.29540000 0.121600000 1.317223e-01 4.510868e-13 TRUE  
MSTRG.10296.14 ENSG00000179364 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS2 protein_coding   22.87726 30.25554 17.22869 3.418814 0.5267221 -0.8120256 2.446754 5.55199043 1.2805384 1.04863183 0.45354841 -2.1076282 0.09707083 0.1800000000 0.07516667 -0.104833333 6.256427e-02 4.510868e-13 FALSE  
MSTRG.10296.2 ENSG00000179364 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS2 protein_coding   22.87726 30.25554 17.22869 3.418814 0.5267221 -0.8120256 0.759460 2.80559970 0.0000000 0.34376540 0.00000000 -8.1372984 0.02932500 0.0981000000 0.00000000 -0.098100000 1.124793e-12 4.510868e-13 FALSE  
MSTRG.10296.6 ENSG00000179364 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS2 protein_coding   22.87726 30.25554 17.22869 3.418814 0.5267221 -0.8120256 2.749669 4.21380761 2.5491390 0.47552703 0.02855209 -0.7228856 0.12107917 0.1395000000 0.14823333 0.008733333 8.463747e-01 4.510868e-13 TRUE  
MSTRG.10296.7 ENSG00000179364 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS2 protein_coding   22.87726 30.25554 17.22869 3.418814 0.5267221 -0.8120256 2.336137 3.72644848 1.2458752 0.29244862 0.21050011 -1.5729746 0.09558750 0.1289333333 0.07190000 -0.057033333 2.227655e-01 4.510868e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179364 E001 0.0000000       14 105300563 105300854 292 +      
ENSG00000179364 E002 0.1451727 0.0431327228 2.266996e-01   14 105300855 105300979 125 + 0.167 0.000 -19.101
ENSG00000179364 E003 0.8836079 0.0136968632 4.306612e-04 1.892326e-03 14 105314415 105314747 333 + 0.582 0.000 -21.715
ENSG00000179364 E004 4.9285834 0.1391746742 1.467621e-06 1.175978e-05 14 105314748 105314879 132 + 1.191 0.162 -5.004
ENSG00000179364 E005 3.4236004 0.1115246147 1.479038e-06 1.184474e-05 14 105314880 105314880 1 + 1.054 0.088 -5.514
ENSG00000179364 E006 3.4236004 0.1115246147 1.479038e-06 1.184474e-05 14 105314881 105314882 2 + 1.054 0.088 -5.514
ENSG00000179364 E007 3.5751159 0.0820681653 1.464385e-07 1.440412e-06 14 105314883 105314886 4 + 1.072 0.088 -5.579
ENSG00000179364 E008 3.5751159 0.0820681653 1.464385e-07 1.440412e-06 14 105314887 105314887 1 + 1.072 0.088 -5.579
ENSG00000179364 E009 3.5751159 0.0820681653 1.464385e-07 1.440412e-06 14 105314888 105314889 2 + 1.072 0.088 -5.579
ENSG00000179364 E010 17.5308761 0.0013312711 5.550532e-04 2.366023e-03 14 105314890 105314975 86 + 1.397 1.127 -0.949
ENSG00000179364 E011 42.3757001 0.0005480715 1.267224e-01 2.295910e-01 14 105314976 105315037 62 + 1.641 1.569 -0.244
ENSG00000179364 E012 0.5870335 0.1486587937 9.913377e-03 2.854845e-02 14 105318168 105318260 93 + 0.459 0.000 -21.128
ENSG00000179364 E013 0.6266857 0.0182272653 4.509632e-01 5.919811e-01 14 105336425 105336658 234 + 0.288 0.162 -1.060
ENSG00000179364 E014 93.2609657 0.0003563949 1.097886e-01 2.052510e-01 14 105348493 105348580 88 + 1.960 1.913 -0.159
ENSG00000179364 E015 0.5149111 0.0203108542 9.583992e-01 9.779179e-01 14 105348581 105348746 166 + 0.167 0.162 -0.058
ENSG00000179364 E016 127.8496448 0.0031951351 4.001757e-01 5.438807e-01 14 105352378 105352467 90 + 2.075 2.056 -0.064
ENSG00000179364 E017 0.5901394 0.2454874317 9.443966e-01 9.691619e-01 14 105355049 105355051 3 + 0.167 0.166 -0.013
ENSG00000179364 E018 151.2816009 0.0044492350 9.414820e-01 9.672082e-01 14 105355052 105355177 126 + 2.120 2.140 0.066
ENSG00000179364 E019 3.3065683 0.0051653118 4.198402e-02 9.469535e-02 14 105355178 105356191 1014 + 0.288 0.664 1.943
ENSG00000179364 E020 0.8460400 0.1679906640 2.103988e-01 3.390127e-01 14 105367041 105367212 172 + 0.000 0.286 18.784
ENSG00000179364 E021 189.8160624 0.0006294390 3.168466e-01 4.596496e-01 14 105367213 105367375 163 + 2.242 2.229 -0.044
ENSG00000179364 E022 71.4712016 0.0008865000 2.670914e-01 4.053821e-01 14 105368074 105368084 11 + 1.839 1.804 -0.119
ENSG00000179364 E023 126.6523160 0.0003235277 7.106079e-02 1.450987e-01 14 105368085 105368147 63 + 2.090 2.045 -0.152
ENSG00000179364 E024 161.0266298 0.0002257493 1.569144e-01 2.709841e-01 14 105368459 105368515 57 + 2.180 2.153 -0.090
ENSG00000179364 E025 102.4742042 0.0004881653 7.891110e-01 8.650035e-01 14 105368516 105368539 24 + 1.949 1.975 0.089
ENSG00000179364 E026 138.8618072 0.0033588581 7.892174e-01 8.650829e-01 14 105369841 105369900 60 + 2.073 2.105 0.105
ENSG00000179364 E027 22.2566130 0.0009330092 1.987214e-06 1.546847e-05 14 105369901 105370158 258 + 0.930 1.401 1.684
ENSG00000179364 E028 185.0106645 0.0016523466 8.407882e-01 9.006334e-01 14 105376768 105376925 158 + 2.211 2.223 0.040
ENSG00000179364 E029 144.4505018 0.0004625396 8.906225e-01 9.341529e-01 14 105379739 105379829 91 + 2.097 2.118 0.070
ENSG00000179364 E030 142.8701900 0.0020896379 2.046003e-01 3.319139e-01 14 105380080 105380154 75 + 2.128 2.098 -0.100
ENSG00000179364 E031 9.3844951 0.0031199213 1.221310e-01 2.229719e-01 14 105380954 105380956 3 + 1.072 0.915 -0.580
ENSG00000179364 E032 183.1081649 0.0002480267 1.908155e-02 4.951598e-02 14 105380957 105381099 143 + 2.249 2.199 -0.168
ENSG00000179364 E033 95.4516492 0.0006055986 7.750541e-02 1.554564e-01 14 105381914 105381923 10 + 1.971 1.917 -0.182
ENSG00000179364 E034 171.5198167 0.0017919662 7.760728e-01 8.558241e-01 14 105381924 105382046 123 + 2.163 2.193 0.098
ENSG00000179364 E035 6.5685555 0.0028252039 7.227599e-01 8.168247e-01 14 105382047 105382058 12 + 0.790 0.851 0.237
ENSG00000179364 E036 160.1980118 0.0034119277 8.860660e-01 9.311478e-01 14 105382477 105382581 105 + 2.136 2.164 0.094
ENSG00000179364 E037 149.5385078 0.0004517676 3.757841e-01 5.201997e-01 14 105382807 105382913 107 + 2.092 2.138 0.153
ENSG00000179364 E038 5.8161655 0.0466870854 1.293522e-04 6.560313e-04 14 105383119 105383358 240 + 1.122 0.541 -2.304
ENSG00000179364 E039 211.8335843 0.0005431246 7.339204e-01 8.250364e-01 14 105383359 105383513 155 + 2.270 2.277 0.025
ENSG00000179364 E040 11.5975446 0.1172216017 2.288187e-03 8.114148e-03 14 105383514 105384352 839 + 1.383 0.799 -2.127
ENSG00000179364 E041 184.3927046 0.0035863382 2.661180e-01 4.042697e-01 14 105384353 105384463 111 + 2.233 2.211 -0.073
ENSG00000179364 E042 174.2718246 0.0002793319 8.415666e-01 9.011800e-01 14 105384879 105384987 109 + 2.184 2.194 0.034
ENSG00000179364 E043 5.7728062 0.1244581210 4.434543e-02 9.901712e-02 14 105385685 105385717 33 + 0.997 0.656 -1.339
ENSG00000179364 E044 52.5783289 0.0006574188 7.524117e-15 2.524210e-13 14 105388622 105389452 831 + 1.908 1.539 -1.248
ENSG00000179364 E045 36.6871443 0.0006579460 8.503176e-08 8.751315e-07 14 105389453 105389960 508 + 1.718 1.419 -1.019
ENSG00000179364 E046 113.0109052 0.0022634462 8.075853e-01 8.777486e-01 14 105389961 105390003 43 + 2.003 2.011 0.027
ENSG00000179364 E047 39.7996400 0.0070376146 1.659827e-07 1.616540e-06 14 105390237 105391206 970 + 1.769 1.432 -1.151
ENSG00000179364 E048 113.1934585 0.0002870261 9.006164e-01 9.405889e-01 14 105391207 105391249 43 + 1.992 2.013 0.069
ENSG00000179364 E049 18.7860293 0.0089283400 7.997903e-07 6.780234e-06 14 105391250 105391458 209 + 1.505 1.083 -1.482
ENSG00000179364 E050 5.6714151 0.0152709400 4.146545e-03 1.355356e-02 14 105391459 105391499 41 + 1.017 0.642 -1.472
ENSG00000179364 E051 12.1899364 0.0015547613 1.350242e-02 3.708162e-02 14 105391500 105391630 131 + 1.217 0.991 -0.816
ENSG00000179364 E052 169.0166481 0.0064361772 2.721995e-02 6.643740e-02 14 105391631 105391766 136 + 2.086 2.217 0.438
ENSG00000179364 E053 4.5234992 0.0036854083 7.929441e-02 1.583890e-01 14 105391767 105392004 238 + 0.852 0.619 -0.951
ENSG00000179364 E054 6.4034425 0.0026002059 2.919400e-02 7.037608e-02 14 105392005 105392618 614 + 0.997 0.741 -0.985
ENSG00000179364 E055 63.5092645 0.0004973986 1.033302e-02 2.958961e-02 14 105392619 105392622 4 + 1.650 1.797 0.496
ENSG00000179364 E056 183.5292469 0.0041715528 7.377280e-03 2.219793e-02 14 105392623 105392760 138 + 2.116 2.252 0.455
ENSG00000179364 E057 149.3323814 0.0006799516 1.288266e-03 4.937351e-03 14 105392761 105392845 85 + 2.032 2.160 0.430
ENSG00000179364 E058 168.2548944 0.0014528932 2.224907e-05 1.364747e-04 14 105393222 105393335 114 + 2.054 2.224 0.569
ENSG00000179364 E059 11.2232202 0.0019864133 8.374082e-01 8.983580e-01 14 105393336 105393543 208 + 1.054 1.047 -0.027
ENSG00000179364 E060 948.0341111 0.0050072030 1.664314e-04 8.198962e-04 14 105394554 105398147 3594 + 2.826 2.968 0.472