ENSG00000179262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316856 ENSG00000179262 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD23A protein_coding protein_coding 120.2131 174.5706 89.40676 2.232545 1.884991 -0.9652764 40.758957 68.782659 25.94720 0.5471498 1.0205333 -1.406120 0.32347500 0.3941000 0.2900000 -0.10410000 1.085498e-11 4.103e-13 FALSE TRUE
ENST00000586534 ENSG00000179262 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD23A protein_coding protein_coding 120.2131 174.5706 89.40676 2.232545 1.884991 -0.9652764 56.156555 87.147138 39.19252 1.3757077 1.8003269 -1.152673 0.45799167 0.4992667 0.4385000 -0.06076667 1.815082e-01 4.103e-13 FALSE TRUE
ENST00000588329 ENSG00000179262 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD23A protein_coding retained_intron 120.2131 174.5706 89.40676 2.232545 1.884991 -0.9652764 8.028755 4.274235 10.52514 0.6607952 0.4946608 1.298100 0.08101667 0.0244000 0.1178333 0.09343333 4.103000e-13 4.103e-13 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179262 E001 4.051463 4.157703e-03 1.538526e-01 2.669057e-01 19 12945782 12945839 58 + 0.787 0.597 -0.793
ENSG00000179262 E002 17.657747 2.734251e-03 7.259102e-02 1.476614e-01 19 12945840 12945854 15 + 1.313 1.180 -0.471
ENSG00000179262 E003 21.782247 1.849129e-03 5.966754e-02 1.260534e-01 19 12945855 12945858 4 + 1.394 1.268 -0.439
ENSG00000179262 E004 25.068208 4.939523e-03 2.793772e-02 6.789081e-02 19 12945859 12945861 3 + 1.469 1.319 -0.518
ENSG00000179262 E005 31.442527 1.120790e-02 1.074686e-01 2.018039e-01 19 12945862 12945865 4 + 1.539 1.430 -0.374
ENSG00000179262 E006 73.512579 7.074557e-03 4.764228e-02 1.049868e-01 19 12945866 12945875 10 + 1.889 1.795 -0.315
ENSG00000179262 E007 235.582200 3.552938e-03 4.544930e-02 1.010211e-01 19 12945876 12945891 16 + 2.365 2.313 -0.174
ENSG00000179262 E008 251.272676 4.519628e-03 8.792352e-02 1.719669e-01 19 12945892 12945893 2 + 2.388 2.343 -0.148
ENSG00000179262 E009 648.021528 2.245378e-03 3.796312e-02 8.727836e-02 19 12945894 12946004 111 + 2.790 2.758 -0.104
ENSG00000179262 E010 509.386971 2.492485e-03 1.874685e-02 4.877611e-02 19 12946005 12946020 16 + 2.694 2.650 -0.146
ENSG00000179262 E011 456.657198 1.114158e-03 8.038552e-03 2.387632e-02 19 12947848 12947853 6 + 2.644 2.605 -0.130
ENSG00000179262 E012 1169.587521 8.543550e-05 9.760409e-03 2.817303e-02 19 12947854 12948009 156 + 3.029 3.022 -0.022
ENSG00000179262 E013 1337.703023 1.476614e-04 1.379233e-01 2.451890e-01 19 12948177 12948358 182 + 3.078 3.085 0.022
ENSG00000179262 E014 618.112780 1.571489e-04 1.817508e-01 3.034230e-01 19 12948497 12948513 17 + 2.746 2.748 0.006
ENSG00000179262 E015 773.968962 1.442721e-04 1.433396e-02 3.898874e-02 19 12948514 12948552 39 + 2.854 2.842 -0.040
ENSG00000179262 E016 550.948223 1.634593e-04 1.379132e-03 5.238754e-03 19 12948686 12948688 3 + 2.721 2.690 -0.102
ENSG00000179262 E017 1196.045146 9.701963e-05 6.428417e-02 1.338438e-01 19 12948689 12948813 125 + 3.033 3.035 0.007
ENSG00000179262 E018 91.009896 1.895713e-03 7.310940e-30 1.218149e-27 19 12948814 12949080 267 + 2.187 1.730 -1.536
ENSG00000179262 E019 498.482734 4.855829e-04 2.362424e-01 3.698236e-01 19 12949081 12949083 3 + 2.619 2.666 0.157
ENSG00000179262 E020 954.563444 9.252131e-04 3.893962e-01 5.335017e-01 19 12949084 12949159 76 + 2.907 2.947 0.131
ENSG00000179262 E021 326.197514 2.828550e-04 9.138764e-01 9.494838e-01 19 12949275 12949277 3 + 2.456 2.476 0.068
ENSG00000179262 E022 1079.541376 1.396071e-03 5.855762e-01 7.092529e-01 19 12949278 12949408 131 + 2.965 2.999 0.114
ENSG00000179262 E023 10.554628 1.587477e-03 3.163288e-07 2.912639e-06 19 12949499 12949576 78 + 1.303 0.810 -1.807
ENSG00000179262 E024 6.596776 3.313770e-02 1.185669e-02 3.318923e-02 19 12951492 12951589 98 + 1.051 0.709 -1.315
ENSG00000179262 E025 25.921629 8.540228e-04 7.057104e-04 2.919417e-03 19 12952364 12952688 325 + 1.526 1.313 -0.738
ENSG00000179262 E026 381.758340 2.284932e-04 6.997979e-01 7.994272e-01 19 12952689 12952696 8 + 2.528 2.543 0.050
ENSG00000179262 E027 940.079640 2.274243e-03 6.421851e-01 7.550303e-01 19 12952697 12952820 124 + 2.923 2.933 0.036
ENSG00000179262 E028 676.779513 2.682282e-03 8.782688e-01 9.258240e-01 19 12952821 12952853 33 + 2.768 2.796 0.092
ENSG00000179262 E029 2356.875096 3.091122e-03 3.598456e-11 6.835622e-10 19 12952936 12953642 707 + 3.184 3.377 0.641