ENSG00000179222

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326587 ENSG00000179222 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED1 protein_coding protein_coding 223.0594 359.4001 162.2908 10.00791 0.7950203 -1.146961 188.14023 317.312074 125.28346 10.8408133 0.7267242 -1.340637 0.82961250 0.882600000 0.7719667 -0.1106333 1.691355e-15 6.481368e-80 FALSE TRUE
ENST00000482188 ENSG00000179222 HEK293_OSMI2_2hA HEK293_TMG_2hB MAGED1 protein_coding processed_transcript 223.0594 359.4001 162.2908 10.00791 0.7950203 -1.146961 10.76897 1.605528 23.71617 0.2780427 1.0001156 3.876402 0.06759583 0.004433333 0.1462000 0.1417667 6.481368e-80 6.481368e-80 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179222 E001 0.5149111 2.034254e-02 7.502207e-01 8.369720e-01 X 51803007 51803058 52 + 0.192 0.141 -0.538
ENSG00000179222 E002 1.3932309 1.016705e-02 9.753798e-01 9.886449e-01 X 51803059 51803073 15 + 0.324 0.332 0.048
ENSG00000179222 E003 47.3839399 1.014609e-02 9.292338e-01 9.595059e-01 X 51803074 51803117 44 + 1.594 1.605 0.038
ENSG00000179222 E004 1.4986628 8.597582e-02 6.524716e-01 7.631683e-01 X 51884979 51885055 77 + 0.425 0.331 -0.537
ENSG00000179222 E005 1.8477772 8.791522e-03 1.581771e-01 2.726876e-01 X 51893533 51893578 46 + 0.577 0.332 -1.275
ENSG00000179222 E006 10.5194308 2.295760e-03 2.401929e-01 3.743538e-01 X 51893579 51893622 44 + 1.082 0.955 -0.467
ENSG00000179222 E007 96.3156611 6.720467e-03 3.188399e-10 5.168414e-09 X 51893623 51893638 16 + 2.145 1.803 -1.147
ENSG00000179222 E008 173.0497908 5.601535e-03 3.767559e-17 1.705910e-15 X 51893639 51893645 7 + 2.423 2.040 -1.281
ENSG00000179222 E009 206.1176628 2.617436e-03 3.366446e-24 3.412313e-22 X 51893646 51893648 3 + 2.483 2.125 -1.196
ENSG00000179222 E010 399.1571965 1.150566e-03 1.788573e-27 2.423747e-25 X 51893649 51893657 9 + 2.713 2.446 -0.889
ENSG00000179222 E011 870.0569798 2.726167e-03 1.280350e-07 1.274063e-06 X 51893658 51893755 98 + 2.969 2.822 -0.487
ENSG00000179222 E012 684.1138245 3.940971e-03 9.118239e-05 4.805994e-04 X 51894269 51894275 7 + 2.851 2.723 -0.428
ENSG00000179222 E013 1181.5365865 3.451786e-03 6.465245e-05 3.541788e-04 X 51894276 51894349 74 + 3.080 2.963 -0.390
ENSG00000179222 E014 3.7922499 4.337757e-03 5.927749e-01 7.152557e-01 X 51894569 51894598 30 + 0.689 0.608 -0.347
ENSG00000179222 E015 10.9329725 1.636033e-03 9.902559e-01 9.980211e-01 X 51894627 51894794 168 + 0.994 0.999 0.017
ENSG00000179222 E016 5129.3616121 1.174643e-03 2.416773e-12 5.570633e-11 X 51895053 51895655 603 + 3.709 3.604 -0.348
ENSG00000179222 E017 1587.2670402 1.254934e-03 1.349381e-02 3.706377e-02 X 51895656 51895760 105 + 3.155 3.110 -0.151
ENSG00000179222 E018 9.0284667 2.380553e-03 8.619059e-07 7.259714e-06 X 51896153 51896322 170 + 1.273 0.747 -1.953
ENSG00000179222 E019 4566.4934989 4.623264e-04 1.560979e-04 7.742854e-04 X 51896409 51897077 669 + 3.608 3.570 -0.127
ENSG00000179222 E020 4.6811669 3.578860e-03 2.354012e-01 3.688429e-01 X 51897078 51897207 130 + 0.816 0.647 -0.690
ENSG00000179222 E021 1411.5885666 9.389465e-05 3.341604e-01 4.779159e-01 X 51897208 51897271 64 + 3.076 3.069 -0.024
ENSG00000179222 E022 6.7000211 2.794354e-03 3.077859e-01 4.500272e-01 X 51897272 51897546 275 + 0.689 0.840 0.610
ENSG00000179222 E023 1645.4996747 4.915968e-04 7.773668e-01 8.567390e-01 X 51897547 51897626 80 + 3.136 3.136 -0.002
ENSG00000179222 E024 1987.6575246 1.670804e-04 9.795057e-02 1.873881e-01 X 51897795 51897886 92 + 3.200 3.222 0.072
ENSG00000179222 E025 16.4131555 5.345354e-03 1.057519e-06 8.731102e-06 X 51897887 51898113 227 + 1.458 1.023 -1.538
ENSG00000179222 E026 1895.5716531 2.023257e-04 1.095044e-01 2.048391e-01 X 51898114 51898193 80 + 3.180 3.202 0.073
ENSG00000179222 E027 22.9694014 8.687418e-04 3.931903e-05 2.270444e-04 X 51898194 51898284 91 + 1.521 1.217 -1.056
ENSG00000179222 E028 1530.1996194 8.577985e-05 4.267212e-03 1.389093e-02 X 51898285 51898327 43 + 3.076 3.112 0.121
ENSG00000179222 E029 36.1731416 5.533015e-04 2.073996e-25 2.361252e-23 X 51898328 51898580 253 + 1.874 1.273 -2.054
ENSG00000179222 E030 1403.2806849 4.430665e-04 1.099209e-03 4.300828e-03 X 51898581 51898610 30 + 3.026 3.079 0.176
ENSG00000179222 E031 1457.0991742 2.666156e-04 5.332000e-06 3.770414e-05 X 51898611 51898643 33 + 3.032 3.098 0.217
ENSG00000179222 E032 22.2315080 4.068686e-03 1.674988e-14 5.347515e-13 X 51898644 51900181 1538 + 1.662 1.069 -2.068
ENSG00000179222 E033 2638.6526796 9.331533e-04 8.028568e-09 1.007344e-07 X 51900182 51900296 115 + 3.262 3.361 0.329
ENSG00000179222 E034 5632.2612868 1.061861e-03 1.820322e-24 1.893764e-22 X 51901553 51901938 386 + 3.542 3.701 0.529
ENSG00000179222 E035 54.8626011 7.532752e-03 2.947146e-01 4.358282e-01 X 51901939 51902145 207 + 1.721 1.656 -0.221
ENSG00000179222 E036 2300.6996499 1.672721e-03 1.077552e-20 7.518930e-19 X 51902146 51902354 209 + 3.114 3.320 0.685