ENSG00000179151

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315127 ENSG00000179151 HEK293_OSMI2_2hA HEK293_TMG_2hB EDC3 protein_coding protein_coding 62.00287 91.34001 41.7705 4.634899 0.39084 -1.128575 43.264416 68.444771 27.150241 1.3415091 0.5336015 -1.3336548 0.6794542 0.75173333 0.6501000 -0.10163333 0.04867684 0.003484004 FALSE TRUE
ENST00000568176 ENSG00000179151 HEK293_OSMI2_2hA HEK293_TMG_2hB EDC3 protein_coding protein_coding 62.00287 91.34001 41.7705 4.634899 0.39084 -1.128575 8.406391 10.841410 7.260861 2.3292460 0.1711512 -0.5776843 0.1459167 0.11683333 0.1739333 0.05710000 0.15511685 0.003484004 FALSE TRUE
ENST00000569606 ENSG00000179151 HEK293_OSMI2_2hA HEK293_TMG_2hB EDC3 protein_coding retained_intron 62.00287 91.34001 41.7705 4.634899 0.39084 -1.128575 5.003627 5.125368 3.099458 0.5734845 0.8666541 -0.7238048 0.0860000 0.05623333 0.0739000 0.01766667 0.80675371 0.003484004   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179151 E001 43.8382264 0.0067790182 7.154302e-09 9.055663e-08 15 74630558 74630574 17 - 1.166 1.684 1.792
ENSG00000179151 E002 2618.5440214 0.0038097090 7.693481e-08 7.986776e-07 15 74630575 74632124 1550 - 3.233 3.395 0.537
ENSG00000179151 E003 681.9846826 0.0001272991 5.424270e-02 1.166733e-01 15 74632125 74632508 384 - 2.732 2.786 0.179
ENSG00000179151 E004 217.2452938 0.0002563011 5.974423e-03 1.854072e-02 15 74632509 74632541 33 - 2.199 2.301 0.340
ENSG00000179151 E005 521.7523672 0.0001463995 8.980243e-07 7.530454e-06 15 74632542 74632732 191 - 2.569 2.683 0.382
ENSG00000179151 E006 807.7400641 0.0001361010 1.411483e-01 2.496138e-01 15 74632733 74632946 214 - 2.814 2.859 0.150
ENSG00000179151 E007 9.3078908 0.0024490279 4.217102e-01 5.648334e-01 15 74635181 74635408 228 - 1.004 0.932 -0.269
ENSG00000179151 E008 687.8587007 0.0017958401 5.335132e-01 6.657038e-01 15 74635409 74635561 153 - 2.772 2.781 0.031
ENSG00000179151 E009 417.4351639 0.0001941791 1.908528e-01 3.148149e-01 15 74635562 74635626 65 - 2.565 2.562 -0.009
ENSG00000179151 E010 23.1586485 0.0009078492 6.243017e-01 7.406586e-01 15 74635627 74635727 101 - 1.337 1.320 -0.058
ENSG00000179151 E011 483.7814951 0.0005173586 6.873764e-04 2.853229e-03 15 74640466 74640560 95 - 2.660 2.615 -0.150
ENSG00000179151 E012 403.3533504 0.0001781346 4.082133e-06 2.961657e-05 15 74640561 74640619 59 - 2.596 2.527 -0.227
ENSG00000179151 E013 406.2309219 0.0002862998 9.909181e-04 3.927391e-03 15 74655733 74655793 61 - 2.580 2.536 -0.148
ENSG00000179151 E014 707.2614188 0.0009126352 6.559105e-04 2.737315e-03 15 74655794 74656019 226 - 2.822 2.778 -0.146
ENSG00000179151 E015 355.8363313 0.0018373613 5.624514e-05 3.128993e-04 15 74656020 74656068 49 - 2.557 2.466 -0.304
ENSG00000179151 E016 409.2319815 0.0030291209 4.380084e-03 1.420612e-02 15 74671455 74671544 90 - 2.601 2.534 -0.222
ENSG00000179151 E017 239.2501976 0.0041040957 1.584974e-02 4.240003e-02 15 74671545 74671567 23 - 2.371 2.300 -0.236
ENSG00000179151 E018 318.4450373 0.0032655729 1.128213e-02 3.183494e-02 15 74671568 74671634 67 - 2.490 2.427 -0.210
ENSG00000179151 E019 250.7103345 0.0022232560 1.022841e-02 2.932729e-02 15 74671635 74671661 27 - 2.384 2.323 -0.202
ENSG00000179151 E020 394.2049425 0.0008661116 2.043053e-06 1.586141e-05 15 74671662 74671774 113 - 2.599 2.511 -0.294
ENSG00000179151 E021 0.4815130 0.0204399525 8.386277e-01 8.991307e-01 15 74674861 74674960 100 - 0.178 0.152 -0.272
ENSG00000179151 E022 310.2872380 0.0008317996 1.057502e-03 4.158342e-03 15 74674961 74675030 70 - 2.476 2.415 -0.202
ENSG00000179151 E023 415.1167714 0.0020358785 5.480816e-03 1.723732e-02 15 74675031 74675142 112 - 2.599 2.545 -0.182
ENSG00000179151 E024 25.3373488 0.0009422617 7.511752e-01 8.376845e-01 15 74676941 74677022 82 - 1.327 1.374 0.163
ENSG00000179151 E025 2.5734488 0.0076074526 8.954741e-01 9.372244e-01 15 74679802 74679925 124 - 0.480 0.519 0.190
ENSG00000179151 E026 74.4055052 0.0042210215 4.180693e-02 9.437346e-02 15 74687091 74687129 39 - 1.708 1.850 0.478
ENSG00000179151 E027 77.0778145 0.0028601192 2.505934e-02 6.199616e-02 15 74687130 74687179 50 - 1.721 1.866 0.490
ENSG00000179151 E028 7.8963161 0.0022450467 7.933184e-03 2.361148e-02 15 74692886 74693018 133 - 1.083 0.795 -1.085
ENSG00000179151 E029 0.2987644 0.0272400515 4.731707e-02   15 74695326 74695369 44 - 0.303 0.000 -12.648
ENSG00000179151 E030 0.2987644 0.0272400515 4.731707e-02   15 74695370 74695422 53 - 0.303 0.000 -12.648
ENSG00000179151 E031 0.7384326 0.0341919915 8.979886e-01 9.388849e-01 15 74695423 74695879 457 - 0.178 0.212 0.319
ENSG00000179151 E032 301.9108576 0.0029006997 7.840022e-02 1.569189e-01 15 74695880 74696029 150 - 2.447 2.412 -0.118
ENSG00000179151 E033 0.9190056 0.0228352174 7.826352e-01 8.604517e-01 15 74696186 74696292 107 - 0.303 0.264 -0.275