ENSG00000179134

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000596271 ENSG00000179134 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD4B protein_coding retained_intron 91.99091 136.2612 59.08284 3.116677 1.440611 -1.205425 22.554242 49.174275 5.937890 8.3779980 1.8747778 -3.04774715 0.21145833 0.36023333 0.09913333 -0.26110000 0.001679521 0.001220592   FALSE
ENST00000598605 ENSG00000179134 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD4B protein_coding protein_coding 91.99091 136.2612 59.08284 3.116677 1.440611 -1.205425 16.190140 20.201808 11.576986 2.3400072 0.6793381 -0.80269299 0.18115417 0.14846667 0.19613333 0.04766667 0.318868998 0.001220592   FALSE
ENST00000598913 ENSG00000179134 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD4B protein_coding protein_coding 91.99091 136.2612 59.08284 3.116677 1.440611 -1.205425 7.207614 9.155934 8.609583 1.6360706 0.8295371 -0.08866383 0.08418750 0.06733333 0.14636667 0.07903333 0.023211703 0.001220592 FALSE TRUE
ENST00000610417 ENSG00000179134 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD4B protein_coding protein_coding 91.99091 136.2612 59.08284 3.116677 1.440611 -1.205425 33.883486 49.280832 23.627098 3.2466512 0.2988354 -1.06026643 0.36917917 0.36183333 0.40046667 0.03863333 0.601644297 0.001220592 FALSE TRUE
MSTRG.17126.3 ENSG00000179134 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD4B protein_coding   91.99091 136.2612 59.08284 3.116677 1.440611 -1.205425 4.254711 3.365869 4.619181 0.7650043 0.5309867 0.45549826 0.05300417 0.02493333 0.07800000 0.05306667 0.001220592 0.001220592 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179134 E001 0.2214452 0.0382881641 9.415361e-01   19 39342421 39342441 21 + 0.000 0.096 10.874
ENSG00000179134 E002 0.2214452 0.0382881641 9.415361e-01   19 39342442 39342451 10 + 0.000 0.096 10.872
ENSG00000179134 E003 2.2759215 0.1417181746 7.310570e-02 1.484947e-01 19 39342452 39342463 12 + 0.688 0.351 -1.639
ENSG00000179134 E004 3.7989997 0.1112087761 2.596308e-02 6.387165e-02 19 39342464 39342467 4 + 0.874 0.479 -1.686
ENSG00000179134 E005 112.2016757 0.0119204981 4.392923e-05 2.509275e-04 19 39342468 39342576 109 + 2.152 1.945 -0.696
ENSG00000179134 E006 28.9011763 0.0216042428 4.658661e-03 1.498191e-02 19 39348288 39348389 102 + 1.590 1.356 -0.803
ENSG00000179134 E007 26.6221364 0.0321861135 3.869802e-03 1.277684e-02 19 39349800 39351816 2017 + 1.561 1.302 -0.893
ENSG00000179134 E008 16.4525098 0.0341580729 3.291855e-05 1.939034e-04 19 39351817 39352374 558 + 1.456 1.003 -1.604
ENSG00000179134 E009 3.5000354 0.4049531023 4.429305e-02 9.891766e-02 19 39352375 39352489 115 + 0.874 0.438 -1.896
ENSG00000179134 E010 2.2571427 0.0284014331 7.604314e-01 8.445488e-01 19 39354004 39354005 2 + 0.499 0.473 -0.130
ENSG00000179134 E011 132.5951026 0.0063737186 5.944914e-06 4.162033e-05 19 39354006 39354066 61 + 2.206 2.027 -0.597
ENSG00000179134 E012 27.2760879 0.0047257937 4.233310e-03 1.379479e-02 19 39355055 39355150 96 + 1.523 1.352 -0.591
ENSG00000179134 E013 159.4354659 0.0087240403 1.756411e-04 8.595664e-04 19 39356689 39356707 19 + 2.270 2.118 -0.508
ENSG00000179134 E014 307.0764356 0.0059144663 3.992472e-05 2.301560e-04 19 39356708 39356815 108 + 2.536 2.412 -0.414
ENSG00000179134 E015 548.8072651 0.0063771269 3.164287e-05 1.872391e-04 19 39356816 39357089 274 + 2.786 2.667 -0.394
ENSG00000179134 E016 7.0425904 0.0026842219 2.059969e-02 5.274572e-02 19 39359905 39360148 244 + 0.604 0.959 1.425
ENSG00000179134 E017 1.2448491 0.0135040142 3.125263e-02 7.439302e-02 19 39369553 39369654 102 + 0.000 0.434 13.675
ENSG00000179134 E018 747.4702680 0.0027190328 2.125431e-07 2.027067e-06 19 39369655 39370091 437 + 2.905 2.810 -0.317
ENSG00000179134 E019 246.3912261 0.0010062175 3.688239e-05 2.143791e-04 19 39370092 39370125 34 + 2.406 2.334 -0.240
ENSG00000179134 E020 611.6314421 0.0029646468 1.213035e-04 6.198888e-04 19 39375650 39375889 240 + 2.800 2.733 -0.222
ENSG00000179134 E021 326.1413998 0.0018296957 2.533100e-03 8.862691e-03 19 39376437 39376495 59 + 2.510 2.467 -0.143
ENSG00000179134 E022 360.8014058 0.0014777093 1.117823e-05 7.344649e-05 19 39376496 39376546 51 + 2.572 2.500 -0.241
ENSG00000179134 E023 399.7572296 0.0036053882 1.254795e-03 4.826057e-03 19 39376705 39376791 87 + 2.612 2.550 -0.208
ENSG00000179134 E024 761.7484251 0.0014952187 6.891860e-04 2.859613e-03 19 39377485 39377824 340 + 2.869 2.840 -0.098
ENSG00000179134 E025 205.5051666 0.0009746514 1.779610e-01 2.985748e-01 19 39378504 39378504 1 + 2.279 2.280 0.005
ENSG00000179134 E026 385.7026696 0.0014694562 3.967757e-03 1.305249e-02 19 39378505 39378589 85 + 2.575 2.543 -0.106
ENSG00000179134 E027 372.8860175 0.0002373457 3.839414e-02 8.809396e-02 19 39379966 39380084 119 + 2.537 2.536 -0.003
ENSG00000179134 E028 299.0056917 0.0022344184 1.776957e-01 2.982275e-01 19 39380587 39380733 147 + 2.380 2.469 0.295
ENSG00000179134 E029 221.5834942 0.0012774685 2.983027e-01 4.397419e-01 19 39380734 39380785 52 + 2.305 2.316 0.037
ENSG00000179134 E030 383.0846043 0.0001697198 1.832906e-01 3.053371e-01 19 39380990 39381113 124 + 2.539 2.554 0.049
ENSG00000179134 E031 1.3503696 0.1765650468 9.170392e-01 9.515925e-01 19 39381114 39381296 183 + 0.360 0.349 -0.062
ENSG00000179134 E032 356.0132025 0.0001589919 9.818428e-01 9.926576e-01 19 39383208 39383291 84 + 2.489 2.530 0.138
ENSG00000179134 E033 192.4408775 0.0002689660 4.602540e-01 6.003052e-01 19 39383292 39383498 207 + 2.208 2.270 0.206
ENSG00000179134 E034 421.6788262 0.0004153886 7.850013e-04 3.205893e-03 19 39383499 39383707 209 + 2.511 2.623 0.375
ENSG00000179134 E035 2728.1163203 0.0035891928 1.361033e-06 1.098142e-05 19 39383708 39385120 1413 + 3.287 3.452 0.547
ENSG00000179134 E036 786.1158228 0.0083896672 2.130439e-08 2.471427e-07 19 39385121 39385351 231 + 2.639 2.942 1.008
ENSG00000179134 E037 674.0144660 0.0164445383 2.534461e-06 1.928220e-05 19 39385352 39385578 227 + 2.536 2.883 1.156
ENSG00000179134 E038 192.5826520 0.0161595086 6.072960e-05 3.350332e-04 19 39385579 39385710 132 + 2.010 2.338 1.099
ENSG00000179134 E039 0.9296148 0.2282876771 9.900503e-01 9.978616e-01 19 39390526 39390528 3 + 0.271 0.291 0.141
ENSG00000179134 E040 10.8239533 0.0020053407 9.485954e-03 2.750192e-02 19 39390529 39391138 610 + 1.183 0.959 -0.813