ENSG00000179051

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375436 ENSG00000179051 HEK293_OSMI2_2hA HEK293_TMG_2hB RCC2 protein_coding protein_coding 129.6504 199.369 100.9913 6.698167 1.523169 -0.9811395 127.2715 198.3438 95.18483 6.449065 0.9391501 -1.059121 0.9780583 0.9949 0.9427333 -0.05216667 3.28706e-09 2.381304e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000179051 E001 4883.851073 0.0050791061 1.311031e-12 3.153916e-11 1 17406760 17407425 666 - 3.447 3.712 0.880
ENSG00000179051 E002 4124.081418 0.0020830938 3.613876e-16 1.445909e-14 1 17407426 17407838 413 - 3.414 3.629 0.712
ENSG00000179051 E003 3777.895382 0.0004236488 2.038360e-03 7.345657e-03 1 17407839 17408554 716 - 3.481 3.559 0.257
ENSG00000179051 E004 1156.208705 0.0014002275 7.972682e-06 5.416534e-05 1 17408555 17408675 121 - 2.920 3.061 0.469
ENSG00000179051 E005 566.324365 0.0019019525 5.495659e-06 3.875148e-05 1 17408676 17408684 9 - 2.589 2.759 0.566
ENSG00000179051 E006 1992.205243 0.0007146392 1.058677e-05 6.997038e-05 1 17408685 17408979 295 - 3.178 3.290 0.371
ENSG00000179051 E007 1557.035682 0.0008479711 2.283942e-07 2.165920e-06 1 17408980 17409194 215 - 3.181 3.139 -0.137
ENSG00000179051 E008 866.046195 0.0002502515 2.414922e-09 3.333817e-08 1 17409974 17410051 78 - 2.927 2.883 -0.145
ENSG00000179051 E009 838.660512 0.0011540102 2.882263e-05 1.721859e-04 1 17412122 17412194 73 - 2.913 2.870 -0.142
ENSG00000179051 E010 949.944858 0.0024184604 7.061689e-04 2.920740e-03 1 17413073 17413178 106 - 2.969 2.924 -0.150
ENSG00000179051 E011 1136.505742 0.0022674000 7.166581e-06 4.922189e-05 1 17413537 17413717 181 - 3.062 2.995 -0.225
ENSG00000179051 E012 1263.334581 0.0023859483 2.039685e-13 5.550305e-12 1 17416480 17416646 167 - 3.156 3.016 -0.466
ENSG00000179051 E013 1045.827038 0.0012332739 1.091038e-16 4.668940e-15 1 17420714 17420828 115 - 3.062 2.940 -0.408
ENSG00000179051 E014 969.594950 0.0020176239 8.421585e-14 2.420640e-12 1 17422203 17422291 89 - 3.039 2.901 -0.458
ENSG00000179051 E015 1052.681518 0.0018878072 1.233711e-12 2.983061e-11 1 17422705 17422836 132 - 3.065 2.943 -0.407
ENSG00000179051 E016 867.870664 0.0030036489 8.835938e-11 1.573845e-09 1 17425541 17425684 144 - 2.995 2.851 -0.477
ENSG00000179051 E017 557.004114 0.0047481871 5.062828e-12 1.106782e-10 1 17429106 17429199 94 - 2.842 2.634 -0.695
ENSG00000179051 E018 495.345343 0.0098595739 6.117811e-17 2.699746e-15 1 17438230 17438522 293 - 2.886 2.505 -1.267
ENSG00000179051 E019 25.349494 0.0053091421 4.467601e-08 4.865894e-07 1 17438523 17438561 39 - 1.605 1.231 -1.295
ENSG00000179051 E020 159.532849 0.0059722116 3.374829e-17 1.537641e-15 1 17439545 17439755 211 - 2.381 2.027 -1.184
ENSG00000179051 E021 2.809825 0.0053123765 5.042867e-07 4.458031e-06 1 17440881 17441053 173 - 0.920 0.165 -3.979
ENSG00000179051 E022 1.926217 0.0078931173 2.464905e-04 1.160663e-03 1 17441458 17441486 29 - 0.746 0.166 -3.301