ENSG00000178971

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000449476 ENSG00000178971 HEK293_OSMI2_2hA HEK293_TMG_2hB CTC1 protein_coding nonsense_mediated_decay 9.40325 9.634695 6.253951 0.8624873 0.5149528 -0.6226627 0.8822317 0.96100841 0.6183659 0.11836972 0.16259894 -0.6278790 0.09777083 0.10240000 0.10220000 -0.00020000 9.879586e-01 2.058994e-06 TRUE  
ENST00000578240 ENSG00000178971 HEK293_OSMI2_2hA HEK293_TMG_2hB CTC1 protein_coding retained_intron 9.40325 9.634695 6.253951 0.8624873 0.5149528 -0.6226627 0.8009892 0.44635114 0.6479778 0.17390263 0.14444924 0.5278947 0.08576667 0.04510000 0.10116667 0.05606667 2.585814e-01 2.058994e-06 TRUE  
ENST00000578441 ENSG00000178971 HEK293_OSMI2_2hA HEK293_TMG_2hB CTC1 protein_coding retained_intron 9.40325 9.634695 6.253951 0.8624873 0.5149528 -0.6226627 0.7106157 0.32521956 0.5149770 0.03654791 0.06533654 0.6471479 0.07832083 0.03493333 0.08363333 0.04870000 4.472198e-02 2.058994e-06 TRUE  
ENST00000578537 ENSG00000178971 HEK293_OSMI2_2hA HEK293_TMG_2hB CTC1 protein_coding nonsense_mediated_decay 9.40325 9.634695 6.253951 0.8624873 0.5149528 -0.6226627 0.2175387 0.69987085 0.0000000 0.35209041 0.00000000 -6.1494847 0.02385000 0.06826667 0.00000000 -0.06826667 2.166579e-01 2.058994e-06 TRUE  
ENST00000581729 ENSG00000178971 HEK293_OSMI2_2hA HEK293_TMG_2hB CTC1 protein_coding protein_coding 9.40325 9.634695 6.253951 0.8624873 0.5149528 -0.6226627 2.2313527 3.42189232 1.5227625 0.58306563 0.42825524 -1.1628701 0.22229583 0.35790000 0.23493333 -0.12296667 4.761908e-01 2.058994e-06 FALSE  
ENST00000581967 ENSG00000178971 HEK293_OSMI2_2hA HEK293_TMG_2hB CTC1 protein_coding retained_intron 9.40325 9.634695 6.253951 0.8624873 0.5149528 -0.6226627 0.9089402 0.48422256 0.7093003 0.19906961 0.08991504 0.5414334 0.09810417 0.04743333 0.11623333 0.06880000 1.422438e-01 2.058994e-06 FALSE  
ENST00000651323 ENSG00000178971 HEK293_OSMI2_2hA HEK293_TMG_2hB CTC1 protein_coding protein_coding 9.40325 9.634695 6.253951 0.8624873 0.5149528 -0.6226627 1.5596926 1.77947353 1.1316044 0.09719901 0.03475413 -0.6484724 0.17087083 0.18673333 0.18393333 -0.00280000 9.932842e-01 2.058994e-06 FALSE  
MSTRG.13620.5 ENSG00000178971 HEK293_OSMI2_2hA HEK293_TMG_2hB CTC1 protein_coding   9.40325 9.634695 6.253951 0.8624873 0.5149528 -0.6226627 0.6343355 0.87362401 0.0000000 0.26053809 0.00000000 -6.4653607 0.07023333 0.08830000 0.00000000 -0.08830000 2.058994e-06 2.058994e-06 FALSE  
MSTRG.13620.7 ENSG00000178971 HEK293_OSMI2_2hA HEK293_TMG_2hB CTC1 protein_coding   9.40325 9.634695 6.253951 0.8624873 0.5149528 -0.6226627 0.4318955 0.04571842 0.6530165 0.04571842 0.09649053 3.5728185 0.04943750 0.00550000 0.10323333 0.09773333 4.154717e-04 2.058994e-06 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178971 E001 70.4692300 0.0003953415 3.675992e-01 5.119651e-01 17 8224815 8226874 2060 - 1.841 1.798 -0.147
ENSG00000178971 E002 7.6463634 0.0340924196 2.606993e-01 3.982671e-01 17 8226875 8226922 48 - 0.992 0.832 -0.605
ENSG00000178971 E003 89.2949069 0.0015884639 5.805651e-01 7.052874e-01 17 8226923 8227935 1013 - 1.930 1.904 -0.090
ENSG00000178971 E004 30.9638980 0.0227368090 2.696472e-01 4.081712e-01 17 8227936 8227981 46 - 1.385 1.490 0.359
ENSG00000178971 E005 58.8507084 0.0005552710 1.570402e-02 4.207320e-02 17 8227982 8228108 127 - 1.646 1.765 0.403
ENSG00000178971 E006 75.1331733 0.0019309807 7.513865e-03 2.254945e-02 17 8228109 8228319 211 - 1.747 1.874 0.427
ENSG00000178971 E007 38.4254134 0.0072831691 6.077691e-01 7.276705e-01 17 8228503 8228548 46 - 1.532 1.567 0.120
ENSG00000178971 E008 47.5333683 0.0036639921 9.923420e-01 9.992888e-01 17 8228549 8228629 81 - 1.646 1.644 -0.007
ENSG00000178971 E009 22.9351774 0.0011630686 9.520063e-01 9.739538e-01 17 8228727 8228784 58 - 1.341 1.333 -0.029
ENSG00000178971 E010 14.2386370 0.0013208056 5.111916e-02 1.111662e-01 17 8228785 8228826 42 - 0.993 1.186 0.701
ENSG00000178971 E011 17.4667808 0.0011231641 3.958190e-03 1.302554e-02 17 8228827 8228892 66 - 1.013 1.284 0.971
ENSG00000178971 E012 23.9070836 0.0010093825 4.703643e-01 6.095890e-01 17 8229142 8229206 65 - 1.312 1.364 0.179
ENSG00000178971 E013 5.3614909 0.0030222017 4.124415e-04 1.822070e-03 17 8229207 8229301 95 - 1.032 0.572 -1.836
ENSG00000178971 E014 29.1538016 0.0008230187 3.977696e-01 5.415353e-01 17 8229302 8229334 33 - 1.401 1.456 0.189
ENSG00000178971 E015 27.9894043 0.0019370478 5.015656e-01 6.377059e-01 17 8229335 8229357 23 - 1.393 1.438 0.155
ENSG00000178971 E016 43.3877440 0.0005674006 1.770757e-01 2.974345e-01 17 8229358 8229446 89 - 1.549 1.623 0.253
ENSG00000178971 E017 29.9834647 0.0075330708 4.207626e-01 5.639451e-01 17 8229891 8229922 32 - 1.401 1.461 0.208
ENSG00000178971 E018 30.2154067 0.0122533190 5.719631e-01 6.981611e-01 17 8229923 8229968 46 - 1.417 1.461 0.155
ENSG00000178971 E019 7.8324029 0.1321868538 8.438092e-03 2.488150e-02 17 8229969 8230267 299 - 1.187 0.687 -1.895
ENSG00000178971 E020 2.9056880 0.0357483424 4.887867e-02 1.071613e-01 17 8230268 8230293 26 - 0.752 0.417 -1.528
ENSG00000178971 E021 36.4050939 0.0008043272 5.039154e-03 1.603757e-02 17 8230294 8230348 55 - 1.393 1.574 0.621
ENSG00000178971 E022 39.6018182 0.0021466863 2.683371e-03 9.323878e-03 17 8230349 8230446 98 - 1.417 1.612 0.669
ENSG00000178971 E023 26.7972274 0.0153239082 1.909479e-01 3.149362e-01 17 8230447 8230468 22 - 1.312 1.435 0.426
ENSG00000178971 E024 36.1195198 0.0176667834 7.970109e-01 8.704850e-01 17 8230563 8230651 89 - 1.513 1.535 0.075
ENSG00000178971 E025 0.3299976 0.0277517361 4.677474e-01   17 8230652 8230933 282 - 0.000 0.163 9.278
ENSG00000178971 E026 40.4652176 0.0107416163 3.523365e-02 8.209311e-02 17 8231276 8231469 194 - 1.454 1.618 0.564
ENSG00000178971 E027 32.4023608 0.0006293725 1.711356e-03 6.317691e-03 17 8231726 8231815 90 - 1.312 1.529 0.749
ENSG00000178971 E028 53.8337643 0.0005420050 1.632835e-02 4.345152e-02 17 8231903 8232227 325 - 1.598 1.722 0.423
ENSG00000178971 E029 31.4339669 0.0006767515 3.411467e-02 7.998519e-02 17 8232361 8232475 115 - 1.359 1.502 0.493
ENSG00000178971 E030 4.7283739 0.0035912266 5.614823e-03 1.759044e-02 17 8232476 8232648 173 - 0.950 0.572 -1.531
ENSG00000178971 E031 6.2573419 0.0027855034 1.121032e-03 4.373931e-03 17 8232712 8232905 194 - 1.068 0.667 -1.553
ENSG00000178971 E032 16.7608806 0.0021650439 2.116566e-01 3.404441e-01 17 8232906 8232911 6 - 1.117 1.230 0.402
ENSG00000178971 E033 31.8851073 0.0081482568 9.342828e-01 9.625709e-01 17 8232912 8233032 121 - 1.468 1.472 0.015
ENSG00000178971 E034 0.0000000       17 8233309 8233362 54 -      
ENSG00000178971 E035 0.0000000       17 8233363 8233456 94 -      
ENSG00000178971 E036 38.7594657 0.0053879276 6.682576e-01 7.752993e-01 17 8234455 8234633 179 - 1.577 1.545 -0.108
ENSG00000178971 E037 18.6189064 0.0339876855 6.767337e-01 7.816202e-01 17 8234634 8234655 22 - 1.281 1.235 -0.164
ENSG00000178971 E038 0.4439371 0.0215789993 1.991253e-02 5.130450e-02 17 8234656 8234748 93 - 0.379 0.000 -12.214
ENSG00000178971 E039 31.4760329 0.0087065845 5.935658e-01 7.159500e-01 17 8234749 8234926 178 - 1.494 1.452 -0.146
ENSG00000178971 E040 28.2761111 0.0007206534 4.758843e-01 6.145651e-01 17 8235053 8235285 233 - 1.454 1.401 -0.183
ENSG00000178971 E041 0.7395785 0.0191354368 4.917312e-01 6.290125e-01 17 8235286 8235366 81 - 0.286 0.163 -1.025
ENSG00000178971 E042 20.4794574 0.0009134703 1.339605e-01 2.396564e-01 17 8235831 8235959 129 - 1.368 1.246 -0.424
ENSG00000178971 E043 15.1607875 0.0196383407 4.129881e-02 9.342904e-02 17 8236058 8236082 25 - 1.303 1.082 -0.784
ENSG00000178971 E044 40.9326800 0.0051552053 5.223158e-03 1.653844e-02 17 8236083 8236342 260 - 1.693 1.511 -0.621
ENSG00000178971 E045 18.5360502 0.0370457328 1.979432e-01 3.236560e-01 17 8237375 8237414 40 - 1.341 1.192 -0.523
ENSG00000178971 E046 24.4771336 0.0088065436 4.238168e-02 9.541732e-02 17 8237415 8237519 105 - 1.468 1.298 -0.588
ENSG00000178971 E047 34.7482724 0.0007616408 3.875944e-04 1.726858e-03 17 8238031 8238242 212 - 1.646 1.428 -0.747
ENSG00000178971 E048 0.0000000       17 8238289 8238391 103 -      
ENSG00000178971 E049 43.9044058 0.0031971109 2.581859e-05 1.560209e-04 17 8238392 8238629 238 - 1.765 1.516 -0.847
ENSG00000178971 E050 24.4638461 0.0008392758 1.686944e-06 1.333778e-05 17 8242985 8243148 164 - 1.571 1.235 -1.165
ENSG00000178971 E051 9.5516937 0.0017699300 8.747225e-03 2.565344e-02 17 8248004 8248056 53 - 1.161 0.881 -1.029