ENSG00000178952

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313511 ENSG00000178952 HEK293_OSMI2_2hA HEK293_TMG_2hB TUFM protein_coding protein_coding 546.2569 916.8421 325.4643 25.8737 10.00059 -1.494146 167.46162 256.70448 118.21396 16.163738 6.913197 -1.1186422 0.32322917 0.27943333 0.3643333 0.08490000 1.052201e-01 1.974002e-21 FALSE TRUE
ENST00000561644 ENSG00000178952 HEK293_OSMI2_2hA HEK293_TMG_2hB TUFM protein_coding retained_intron 546.2569 916.8421 325.4643 25.8737 10.00059 -1.494146 21.02371 12.12601 23.92905 1.347401 2.992536 0.9800714 0.04944167 0.01316667 0.0731000 0.05993333 1.974002e-21 1.974002e-21 FALSE FALSE
ENST00000569217 ENSG00000178952 HEK293_OSMI2_2hA HEK293_TMG_2hB TUFM protein_coding retained_intron 546.2569 916.8421 325.4643 25.8737 10.00059 -1.494146 51.27377 62.79098 36.67900 10.452328 3.018260 -0.7754396 0.10500000 0.06836667 0.1123667 0.04400000 9.446406e-02 1.974002e-21 FALSE TRUE
MSTRG.12368.2 ENSG00000178952 HEK293_OSMI2_2hA HEK293_TMG_2hB TUFM protein_coding   546.2569 916.8421 325.4643 25.8737 10.00059 -1.494146 170.35167 355.07895 65.51478 2.999361 3.991173 -2.4380680 0.27715417 0.38806667 0.2009667 -0.18710000 1.103470e-15 1.974002e-21 FALSE TRUE
MSTRG.12368.3 ENSG00000178952 HEK293_OSMI2_2hA HEK293_TMG_2hB TUFM protein_coding   546.2569 916.8421 325.4643 25.8737 10.00059 -1.494146 135.00775 228.78757 80.11588 11.668424 6.263629 -1.5137316 0.24275833 0.24956667 0.2460667 -0.00350000 9.754210e-01 1.974002e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178952 E001 101.14791 2.284371e-03 1.707914e-01 2.891968e-01 16 28842411 28842732 322 - 1.859 1.920 0.206
ENSG00000178952 E002 75.87484 1.237781e-03 3.510325e-01 4.952380e-01 16 28842733 28842786 54 - 1.751 1.792 0.139
ENSG00000178952 E003 739.81449 2.651623e-04 1.404004e-20 9.612737e-19 16 28842787 28842837 51 - 2.623 2.793 0.566
ENSG00000178952 E004 8584.09377 9.760751e-04 4.080245e-03 1.336876e-02 16 28842838 28843148 311 - 3.801 3.836 0.116
ENSG00000178952 E005 6120.66231 5.054955e-04 2.105701e-05 1.299241e-04 16 28843736 28843855 120 - 3.647 3.690 0.143
ENSG00000178952 E006 17.96057 6.987412e-03 8.466253e-02 1.668549e-01 16 28843919 28843949 31 - 1.311 1.137 -0.616
ENSG00000178952 E007 2248.64523 5.001370e-04 2.336053e-04 1.106672e-03 16 28843950 28843951 2 - 3.211 3.256 0.150
ENSG00000178952 E008 5903.48587 4.824889e-05 4.131467e-19 2.380457e-17 16 28843952 28844101 150 - 3.626 3.675 0.163
ENSG00000178952 E009 257.27280 7.769833e-03 5.419184e-13 1.387362e-11 16 28844102 28844229 128 - 2.571 2.211 -1.199
ENSG00000178952 E010 6093.22448 3.787127e-04 1.949788e-05 1.212956e-04 16 28844230 28844334 105 - 3.650 3.687 0.125
ENSG00000178952 E011 6860.76016 3.704831e-04 6.523734e-05 3.570732e-04 16 28844419 28844551 133 - 3.705 3.738 0.109
ENSG00000178952 E012 74.84416 3.568763e-04 3.792686e-28 5.430937e-26 16 28844626 28844697 72 - 2.112 1.634 -1.609
ENSG00000178952 E013 6813.12323 2.452861e-05 1.356648e-03 5.165154e-03 16 28844698 28844862 165 - 3.748 3.722 -0.083
ENSG00000178952 E014 4244.05253 1.472092e-04 1.126143e-14 3.675816e-13 16 28844951 28845055 105 - 3.579 3.508 -0.238
ENSG00000178952 E015 4894.84226 7.214205e-04 9.694856e-17 4.176129e-15 16 28845314 28845480 167 - 3.678 3.560 -0.392
ENSG00000178952 E016 4637.18376 2.634155e-03 5.226459e-05 2.931203e-04 16 28845912 28846106 195 - 3.643 3.540 -0.344
ENSG00000178952 E017 1866.03363 7.449944e-03 3.250755e-01 4.685091e-01 16 28846218 28846413 196 - 3.203 3.157 -0.152