ENSG00000178950

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314167 ENSG00000178950 HEK293_OSMI2_2hA HEK293_TMG_2hB GAK protein_coding protein_coding 38.35781 62.22578 22.45348 7.292884 0.2175399 -1.470162 14.6452146 22.232213 9.2546425 1.7344284 1.1282971 -1.2634931 0.38969583 0.36260000 0.413100000 0.05050000 7.691722e-01 4.82705e-40 FALSE TRUE
ENST00000504668 ENSG00000178950 HEK293_OSMI2_2hA HEK293_TMG_2hB GAK protein_coding nonsense_mediated_decay 38.35781 62.22578 22.45348 7.292884 0.2175399 -1.470162 3.7037519 12.241892 0.0000000 1.9049858 0.0000000 -10.2587888 0.06313333 0.19630000 0.000000000 -0.19630000 4.827050e-40 4.82705e-40 FALSE TRUE
ENST00000504947 ENSG00000178950 HEK293_OSMI2_2hA HEK293_TMG_2hB GAK protein_coding retained_intron 38.35781 62.22578 22.45348 7.292884 0.2175399 -1.470162 1.8118838 1.476695 1.8247157 0.4092147 0.3846084 0.3034475 0.05453750 0.02293333 0.081266667 0.05833333 8.220807e-03 4.82705e-40   FALSE
ENST00000510799 ENSG00000178950 HEK293_OSMI2_2hA HEK293_TMG_2hB GAK protein_coding protein_coding 38.35781 62.22578 22.45348 7.292884 0.2175399 -1.470162 1.1695058 4.310543 0.0000000 2.5935314 0.0000000 -8.7550688 0.01828333 0.06140000 0.000000000 -0.06140000 2.556850e-01 4.82705e-40 FALSE TRUE
MSTRG.24428.10 ENSG00000178950 HEK293_OSMI2_2hA HEK293_TMG_2hB GAK protein_coding   38.35781 62.22578 22.45348 7.292884 0.2175399 -1.470162 2.0917315 0.000000 2.8069912 0.0000000 1.4035141 8.1380112 0.07575000 0.00000000 0.124300000 0.12430000 1.080470e-01 4.82705e-40 FALSE TRUE
MSTRG.24428.11 ENSG00000178950 HEK293_OSMI2_2hA HEK293_TMG_2hB GAK protein_coding   38.35781 62.22578 22.45348 7.292884 0.2175399 -1.470162 1.8126165 2.200837 1.6866144 1.1237016 1.0740781 -0.3819340 0.05012500 0.03953333 0.075900000 0.03636667 9.566936e-01 4.82705e-40 FALSE TRUE
MSTRG.24428.15 ENSG00000178950 HEK293_OSMI2_2hA HEK293_TMG_2hB GAK protein_coding   38.35781 62.22578 22.45348 7.292884 0.2175399 -1.470162 3.0949543 6.429518 0.2152787 1.4101338 0.2152787 -4.8371698 0.06779167 0.10346667 0.009666667 -0.09380000 4.239332e-02 4.82705e-40 FALSE TRUE
MSTRG.24428.18 ENSG00000178950 HEK293_OSMI2_2hA HEK293_TMG_2hB GAK protein_coding   38.35781 62.22578 22.45348 7.292884 0.2175399 -1.470162 0.6671974 3.616017 0.0000000 0.5713939 0.0000000 -8.5022420 0.01130417 0.05756667 0.000000000 -0.05756667 1.343742e-23 4.82705e-40 FALSE TRUE
MSTRG.24428.19 ENSG00000178950 HEK293_OSMI2_2hA HEK293_TMG_2hB GAK protein_coding   38.35781 62.22578 22.45348 7.292884 0.2175399 -1.470162 1.1946714 0.000000 1.4244302 0.0000000 0.7326780 7.1643340 0.03966667 0.00000000 0.062966667 0.06296667 1.020136e-01 4.82705e-40 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178950 E001 0.1451727 0.0429805708 1.767107e-01   4 849276 849276 1 - 0.185 0.000 -11.269
ENSG00000178950 E002 2.5838282 0.0526572866 7.350161e-03 2.212890e-02 4 849277 849277 1 - 0.000 0.597 15.283
ENSG00000178950 E003 5.3076480 0.0338234626 3.545123e-01 4.988250e-01 4 849278 849280 3 - 0.623 0.786 0.677
ENSG00000178950 E004 13.9699777 0.0538400297 2.898920e-01 4.306542e-01 4 849281 849283 3 - 0.979 1.151 0.626
ENSG00000178950 E005 16.0597354 0.0481602852 1.692113e-01 2.871654e-01 4 849284 849289 6 - 1.003 1.213 0.759
ENSG00000178950 E006 19.0823912 0.0233205995 1.151199e-01 2.130171e-01 4 849290 849299 10 - 1.086 1.280 0.690
ENSG00000178950 E007 42.6274136 0.0078309598 1.276051e-03 4.897274e-03 4 849300 849306 7 - 1.359 1.623 0.907
ENSG00000178950 E008 43.8785923 0.0076383155 6.216281e-04 2.612369e-03 4 849307 849307 1 - 1.359 1.637 0.955
ENSG00000178950 E009 61.2445141 0.0028500674 3.876922e-03 1.279745e-02 4 849308 849317 10 - 1.583 1.762 0.606
ENSG00000178950 E010 148.0323558 0.0002502994 1.830044e-14 5.800509e-13 4 849318 849396 79 - 1.856 2.153 0.995
ENSG00000178950 E011 205.2626783 0.0002945661 1.043048e-08 1.280804e-07 4 849397 849462 66 - 2.092 2.274 0.611
ENSG00000178950 E012 304.3958377 0.0007613635 3.347502e-12 7.540717e-11 4 849463 849577 115 - 2.246 2.449 0.677
ENSG00000178950 E013 421.7692826 0.0001344704 2.109785e-20 1.414841e-18 4 849578 849774 197 - 2.384 2.590 0.685
ENSG00000178950 E014 521.8702993 0.0008203924 4.241342e-14 1.272181e-12 4 849892 850068 177 - 2.499 2.680 0.605
ENSG00000178950 E015 14.3296356 0.0012586637 7.118703e-01 8.087318e-01 4 850069 850409 341 - 1.139 1.105 -0.124
ENSG00000178950 E016 11.2917606 0.0070288363 2.871320e-03 9.887181e-03 4 850410 850935 526 - 1.243 0.932 -1.131
ENSG00000178950 E017 423.7789407 0.0058735730 1.425649e-02 3.880920e-02 4 850936 851017 82 - 2.467 2.580 0.376
ENSG00000178950 E018 341.1822066 0.0089348301 1.708610e-01 2.892915e-01 4 851018 851084 67 - 2.400 2.480 0.265
ENSG00000178950 E019 32.6841652 0.0117960171 1.659109e-06 1.313250e-05 4 851085 851749 665 - 1.709 1.328 -1.306
ENSG00000178950 E020 359.3188398 0.0020237698 2.146651e-04 1.026961e-03 4 851750 851852 103 - 2.387 2.509 0.406
ENSG00000178950 E021 373.6673847 0.0010684107 1.170703e-03 4.541355e-03 4 851853 851974 122 - 2.427 2.519 0.305
ENSG00000178950 E022 18.2486164 0.0010004475 1.045652e-02 2.987868e-02 4 851975 853828 1854 - 1.369 1.156 -0.748
ENSG00000178950 E023 2.3939094 0.0063492797 2.108798e-01 3.395884e-01 4 859362 859493 132 - 0.623 0.414 -1.006
ENSG00000178950 E024 353.5535168 0.0017344193 6.707905e-03 2.046464e-02 4 859606 859722 117 - 2.408 2.494 0.288
ENSG00000178950 E025 342.3407053 0.0003208680 7.450239e-06 5.095767e-05 4 865122 865244 123 - 2.372 2.483 0.372
ENSG00000178950 E026 294.6049813 0.0001567941 7.064278e-06 4.860559e-05 4 866364 866501 138 - 2.304 2.419 0.385
ENSG00000178950 E027 87.5099594 0.0003132724 1.467970e-02 3.976871e-02 4 866502 866534 33 - 1.783 1.896 0.382
ENSG00000178950 E028 489.8949069 0.0001495899 6.790401e-06 4.691885e-05 4 866956 867346 391 - 2.543 2.634 0.301
ENSG00000178950 E029 277.0872489 0.0007329160 4.549730e-01 5.955453e-01 4 867347 867432 86 - 2.353 2.377 0.079
ENSG00000178950 E030 345.7974949 0.0003181038 2.742316e-01 4.133602e-01 4 868539 868685 147 - 2.443 2.472 0.094
ENSG00000178950 E031 2.2905815 0.0220377598 8.191846e-02 1.625705e-01 4 868686 869957 1272 - 0.675 0.379 -1.423
ENSG00000178950 E032 418.2640906 0.0005207984 6.880297e-01 7.902341e-01 4 870711 870904 194 - 2.551 2.546 -0.019
ENSG00000178950 E033 0.2214452 0.0377235494 1.000000e+00   4 872266 872773 508 - 0.000 0.079 11.599
ENSG00000178950 E034 241.1256314 0.0007885298 1.041097e-01 1.967610e-01 4 876530 876609 80 - 2.342 2.299 -0.146
ENSG00000178950 E035 287.4470731 0.0001848155 7.858561e-04 3.208856e-03 4 877090 877207 118 - 2.442 2.365 -0.258
ENSG00000178950 E036 315.2484703 0.0001883172 8.077563e-03 2.397678e-02 4 877615 877809 195 - 2.467 2.409 -0.194
ENSG00000178950 E037 227.4160576 0.0001943832 2.266735e-01 3.584233e-01 4 881907 882040 134 - 2.305 2.275 -0.101
ENSG00000178950 E038 191.3617323 0.0002357994 8.490802e-02 1.672601e-01 4 882697 882767 71 - 2.247 2.199 -0.160
ENSG00000178950 E039 181.4776825 0.0002185437 2.234739e-03 7.950509e-03 4 882768 882819 52 - 2.253 2.165 -0.294
ENSG00000178950 E040 307.3028530 0.0001870745 2.160192e-05 1.328677e-04 4 883315 883463 149 - 2.486 2.392 -0.315
ENSG00000178950 E041 182.4800440 0.0002473628 2.475662e-08 2.834049e-07 4 884037 884086 50 - 2.305 2.146 -0.531
ENSG00000178950 E042 15.5251161 0.0094211468 1.689203e-04 8.304947e-04 4 884087 884390 304 - 1.388 1.025 -1.288
ENSG00000178950 E043 61.0724133 0.0177670352 1.263783e-07 1.258978e-06 4 885783 888846 3064 - 1.994 1.580 -1.398
ENSG00000178950 E044 232.9702449 0.0001827467 1.403151e-05 9.008801e-05 4 888847 888970 124 - 2.377 2.267 -0.367
ENSG00000178950 E045 164.0080069 0.0013841600 2.185407e-04 1.043184e-03 4 890532 890622 91 - 2.234 2.109 -0.419
ENSG00000178950 E046 140.6241164 0.0004816401 2.488088e-03 8.728380e-03 4 893377 893418 42 - 2.153 2.052 -0.337
ENSG00000178950 E047 153.3281694 0.0011401093 9.871391e-04 3.914811e-03 4 893419 893489 71 - 2.198 2.085 -0.375
ENSG00000178950 E048 151.9397131 0.0003276090 1.116053e-08 1.363643e-07 4 893874 893942 69 - 2.240 2.061 -0.596
ENSG00000178950 E049 158.1797939 0.0002586869 6.229397e-09 7.989578e-08 4 893943 894009 67 - 2.258 2.082 -0.589
ENSG00000178950 E050 14.9077603 0.0015348566 1.268892e-08 1.534260e-07 4 894010 894827 818 - 1.450 0.952 -1.772
ENSG00000178950 E051 108.5121537 0.0003045584 3.320906e-04 1.508936e-03 4 896460 896468 9 - 2.065 1.933 -0.442
ENSG00000178950 E052 185.3684588 0.0002248449 1.285130e-08 1.552704e-07 4 896469 896549 81 - 2.314 2.154 -0.535
ENSG00000178950 E053 0.9158852 0.0157888032 2.403374e-01 3.745266e-01 4 897976 898032 57 - 0.415 0.203 -1.424
ENSG00000178950 E054 129.5441306 0.0002757331 1.015411e-03 4.012066e-03 4 898033 898061 29 - 2.124 2.013 -0.373
ENSG00000178950 E055 154.2706829 0.0011267552 9.936805e-05 5.188947e-04 4 898062 898158 97 - 2.213 2.082 -0.442
ENSG00000178950 E056 79.4811332 0.0067377434 3.571469e-03 1.193179e-02 4 904637 904652 16 - 1.954 1.790 -0.555
ENSG00000178950 E057 93.2331665 0.0023117634 1.326479e-02 3.653651e-02 4 904653 904686 34 - 1.984 1.873 -0.372
ENSG00000178950 E058 120.9547848 0.0050682226 3.472314e-02 8.111931e-02 4 904687 904774 88 - 2.088 1.988 -0.334
ENSG00000178950 E059 65.4032301 0.0058105109 9.374059e-02 1.809692e-01 4 904775 904779 5 - 1.823 1.726 -0.328
ENSG00000178950 E060 1.1897566 0.0196216989 3.775488e-01 5.218872e-01 4 904780 904781 2 - 0.415 0.254 -1.007
ENSG00000178950 E061 89.6253761 0.0081098710 1.080321e-01 2.026212e-01 4 911673 911718 46 - 1.956 1.864 -0.311
ENSG00000178950 E062 101.8695778 0.0061919726 1.298471e-02 3.587501e-02 4 911719 911787 69 - 2.038 1.907 -0.437
ENSG00000178950 E063 1.7680789 0.1132517801 2.116394e-01 3.404240e-01 4 911788 911842 55 - 0.185 0.468 1.863
ENSG00000178950 E064 1.8423623 0.0081333665 2.348285e-02 5.874479e-02 4 912030 912084 55 - 0.000 0.476 15.290
ENSG00000178950 E065 1.6241263 0.1273087482 3.125314e-01 4.550644e-01 4 912085 912174 90 - 0.185 0.415 1.587
ENSG00000178950 E066 1.4758211 0.5188621142 7.427059e-01 8.315451e-01 4 912462 912734 273 - 0.414 0.315 -0.585
ENSG00000178950 E067 96.3005069 0.0060789198 1.608677e-02 4.293168e-02 4 912735 912794 60 - 2.009 1.881 -0.431
ENSG00000178950 E068 110.0208889 0.0007244683 4.479655e-07 4.000270e-06 4 913607 913668 62 - 2.105 1.915 -0.635
ENSG00000178950 E069 0.4428904 0.3974394014 7.528858e-01 8.389770e-01 4 913669 914029 361 - 0.000 0.151 11.448
ENSG00000178950 E070 0.0000000       4 915498 915756 259 -      
ENSG00000178950 E071 148.4256048 0.0115879858 6.121524e-04 2.577622e-03 4 932043 932373 331 - 2.241 2.046 -0.653