ENSG00000178927

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306645 ENSG00000178927 HEK293_OSMI2_2hA HEK293_TMG_2hB CYBC1 protein_coding protein_coding 40.36995 60.32072 20.79292 4.392749 1.939611 -1.536107 10.737761 18.6967269 3.797550 0.8765460 0.8227935 -2.2966221 0.24382917 0.31130000 0.19246667 -0.11883333 0.313716962 0.0006219487 FALSE  
ENST00000434650 ENSG00000178927 HEK293_OSMI2_2hA HEK293_TMG_2hB CYBC1 protein_coding protein_coding 40.36995 60.32072 20.79292 4.392749 1.939611 -1.536107 3.801494 6.6866002 1.076195 1.0965593 0.4632656 -2.6241455 0.09053750 0.11260000 0.05163333 -0.06096667 0.380871937 0.0006219487 FALSE  
ENST00000577732 ENSG00000178927 HEK293_OSMI2_2hA HEK293_TMG_2hB CYBC1 protein_coding protein_coding 40.36995 60.32072 20.79292 4.392749 1.939611 -1.536107 3.980423 5.3378610 2.594405 0.4136457 0.2506916 -1.0380081 0.10212083 0.08886667 0.12780000 0.03893333 0.336983538 0.0006219487 FALSE  
ENST00000578895 ENSG00000178927 HEK293_OSMI2_2hA HEK293_TMG_2hB CYBC1 protein_coding retained_intron 40.36995 60.32072 20.79292 4.392749 1.939611 -1.536107 2.620708 2.4345664 1.614241 0.3596387 0.1834861 -0.5898128 0.07102083 0.03996667 0.07900000 0.03903333 0.017016320 0.0006219487 FALSE  
ENST00000584024 ENSG00000178927 HEK293_OSMI2_2hA HEK293_TMG_2hB CYBC1 protein_coding nonsense_mediated_decay 40.36995 60.32072 20.79292 4.392749 1.939611 -1.536107 4.261382 8.6637164 1.636713 0.8081606 0.2902369 -2.3970613 0.09551250 0.14573333 0.07780000 -0.06793333 0.045894201 0.0006219487 FALSE  
ENST00000584791 ENSG00000178927 HEK293_OSMI2_2hA HEK293_TMG_2hB CYBC1 protein_coding processed_transcript 40.36995 60.32072 20.79292 4.392749 1.939611 -1.536107 1.877540 2.1509324 1.250917 0.1339857 0.3591584 -0.7771807 0.05027917 0.03573333 0.05910000 0.02336667 0.466635153 0.0006219487    
ENST00000585044 ENSG00000178927 HEK293_OSMI2_2hA HEK293_TMG_2hB CYBC1 protein_coding retained_intron 40.36995 60.32072 20.79292 4.392749 1.939611 -1.536107 2.307539 1.8938410 1.630702 0.2290757 0.1416393 -0.2146002 0.06540000 0.03156667 0.08026667 0.04870000 0.002278019 0.0006219487 FALSE  
ENST00000585064 ENSG00000178927 HEK293_OSMI2_2hA HEK293_TMG_2hB CYBC1 protein_coding protein_coding 40.36995 60.32072 20.79292 4.392749 1.939611 -1.536107 1.436248 0.1846685 1.150747 0.1846685 0.1147076 2.5759623 0.04363750 0.00270000 0.05706667 0.05436667 0.011521872 0.0006219487 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178927 E001 2.808501 0.0108186400 9.183709e-03 2.674434e-02 17 82442586 82442588 3 - 0.821 0.402 -1.882
ENSG00000178927 E002 7.073917 0.0024081069 3.655534e-02 8.463136e-02 17 82442589 82442642 54 - 1.015 0.747 -1.030
ENSG00000178927 E003 8.554959 0.0020384500 4.468726e-01 5.883324e-01 17 82442643 82442643 1 - 0.960 0.862 -0.369
ENSG00000178927 E004 269.113527 0.0026566244 3.875431e-10 6.194640e-09 17 82442644 82442899 256 - 2.110 2.357 0.824
ENSG00000178927 E005 359.310134 0.0016633427 1.174413e-11 2.417307e-10 17 82442900 82443059 160 - 2.257 2.477 0.733
ENSG00000178927 E006 575.466171 0.0002487006 1.219121e-05 7.938367e-05 17 82443060 82443448 389 - 2.577 2.661 0.282
ENSG00000178927 E007 111.512554 0.0003552228 6.156294e-01 7.338655e-01 17 82443449 82443455 7 - 1.918 1.938 0.067
ENSG00000178927 E008 165.288416 0.0002071677 7.683961e-01 8.503387e-01 17 82443456 82443505 50 - 2.100 2.108 0.029
ENSG00000178927 E009 140.385378 0.0013075211 9.036808e-01 9.427212e-01 17 82443506 82443531 26 - 2.037 2.042 0.015
ENSG00000178927 E010 186.580823 0.0002525043 5.011621e-02 1.093708e-01 17 82443532 82443626 95 - 2.108 2.172 0.215
ENSG00000178927 E011 118.728978 0.0006476934 3.124730e-02 7.438219e-02 17 82443627 82443659 33 - 1.887 1.979 0.309
ENSG00000178927 E012 155.776923 0.0008382712 3.245301e-02 7.672209e-02 17 82443660 82443822 163 - 2.012 2.094 0.275
ENSG00000178927 E013 10.881728 0.0024622817 4.721401e-01 6.111963e-01 17 82443823 82443848 26 - 0.896 0.985 0.336
ENSG00000178927 E014 3.941861 0.0454844031 8.039254e-01 8.752342e-01 17 82443849 82443891 43 - 0.544 0.596 0.237
ENSG00000178927 E015 8.681327 0.0032451075 4.100619e-01 5.536866e-01 17 82443892 82443901 10 - 0.778 0.892 0.446
ENSG00000178927 E016 9.199358 0.0020553847 3.019343e-01 4.437608e-01 17 82443902 82443902 1 - 0.778 0.919 0.550
ENSG00000178927 E017 55.605066 0.0004436710 3.672830e-01 5.116506e-01 17 82443903 82443936 34 - 1.599 1.651 0.179
ENSG00000178927 E018 119.077725 0.0004299321 2.610447e-01 3.986597e-01 17 82443937 82443996 60 - 1.931 1.976 0.154
ENSG00000178927 E019 124.480621 0.0008748246 2.320060e-01 3.648296e-01 17 82443997 82444034 38 - 1.946 1.996 0.168
ENSG00000178927 E020 138.698870 0.0020154280 1.428905e-01 2.519750e-01 17 82444035 82444072 38 - 1.982 2.046 0.217
ENSG00000178927 E021 157.793179 0.0003037052 5.168969e-02 1.121650e-01 17 82444073 82444124 52 - 2.030 2.100 0.235
ENSG00000178927 E022 11.867961 0.0014383167 8.470692e-02 1.669316e-01 17 82444205 82444388 184 - 1.149 0.961 -0.685
ENSG00000178927 E023 8.351321 0.0022000681 6.095825e-02 1.282474e-01 17 82444389 82444446 58 - 1.041 0.809 -0.877
ENSG00000178927 E024 149.517993 0.0005588738 3.995608e-01 5.433026e-01 17 82444447 82444464 18 - 2.040 2.071 0.104
ENSG00000178927 E025 124.119458 0.0002493218 7.645160e-01 8.475698e-01 17 82444465 82444470 6 - 1.976 1.986 0.035
ENSG00000178927 E026 152.477249 0.0003911435 4.996629e-01 6.359525e-01 17 82444471 82444497 27 - 2.054 2.078 0.080
ENSG00000178927 E027 158.037586 0.0002636016 2.246599e-01 3.560201e-01 17 82444498 82444530 33 - 2.054 2.097 0.142
ENSG00000178927 E028 121.135355 0.0003444038 2.699609e-01 4.085254e-01 17 82444531 82444536 6 - 1.940 1.984 0.148
ENSG00000178927 E029 182.491013 0.0002560894 3.043422e-01 4.463457e-01 17 82444537 82444591 55 - 2.125 2.158 0.110
ENSG00000178927 E030 27.145620 0.0007575927 3.349633e-01 4.787063e-01 17 82444592 82445186 595 - 1.404 1.326 -0.269
ENSG00000178927 E031 10.190194 0.0017306721 6.552818e-02 1.359215e-01 17 82445251 82445462 212 - 0.730 0.985 0.987
ENSG00000178927 E032 4.743705 0.0036155063 5.814825e-02 1.234536e-01 17 82445463 82445504 42 - 0.352 0.706 1.708
ENSG00000178927 E033 3.862264 0.0043953567 1.481445e-01 2.591557e-01 17 82445505 82445557 53 - 0.352 0.626 1.372
ENSG00000178927 E034 14.022629 0.0106551883 3.972618e-02 9.051554e-02 17 82445558 82445863 306 - 1.236 1.010 -0.811
ENSG00000178927 E035 146.009963 0.0003744232 5.088225e-01 6.442002e-01 17 82445864 82445880 17 - 2.035 2.058 0.078
ENSG00000178927 E036 246.082614 0.0002228784 5.196902e-01 6.537607e-01 17 82445881 82445956 76 - 2.293 2.274 -0.065
ENSG00000178927 E037 148.797446 0.0002180019 7.613599e-02 1.533249e-01 17 82445957 82445960 4 - 2.112 2.049 -0.213
ENSG00000178927 E038 174.949720 0.0002585275 5.032255e-02 1.097389e-01 17 82446623 82446692 70 - 2.182 2.117 -0.218
ENSG00000178927 E039 84.998161 0.0008623208 9.915668e-03 2.855374e-02 17 82446693 82446696 4 - 1.914 1.793 -0.410
ENSG00000178927 E040 62.121838 0.0194091332 7.685739e-04 3.145271e-03 17 82446697 82447579 883 - 1.898 1.620 -0.943
ENSG00000178927 E041 138.053617 0.0010351106 1.854963e-02 4.834003e-02 17 82447580 82447621 42 - 2.100 2.008 -0.307
ENSG00000178927 E042 9.940616 0.0619117299 4.769885e-02 1.050818e-01 17 82447622 82447646 25 - 1.150 0.854 -1.094
ENSG00000178927 E043 23.523887 0.0071703174 6.793713e-06 4.693660e-05 17 82447647 82447850 204 - 1.556 1.176 -1.321
ENSG00000178927 E044 22.690064 0.0008402753 6.856628e-06 4.732640e-05 17 82447851 82447927 77 - 1.524 1.174 -1.221
ENSG00000178927 E045 38.686560 0.0053236567 4.232210e-08 4.632421e-07 17 82447928 82448853 926 - 1.762 1.387 -1.282
ENSG00000178927 E046 23.881877 0.0161653724 1.865369e-06 1.461189e-05 17 82448854 82449169 316 - 1.606 1.159 -1.553
ENSG00000178927 E047 116.784886 0.0002951027 9.379763e-03 2.723239e-02 17 82449170 82449173 4 - 2.037 1.934 -0.346
ENSG00000178927 E048 190.281978 0.0015986136 6.104560e-03 1.888425e-02 17 82449174 82449292 119 - 2.245 2.147 -0.327
ENSG00000178927 E049 21.256402 0.0225140074 1.860593e-04 9.038508e-04 17 82449293 82449430 138 - 1.524 1.136 -1.354
ENSG00000178927 E050 20.706853 0.0138889782 1.611998e-02 4.300153e-02 17 82449431 82449431 1 - 1.414 1.175 -0.838
ENSG00000178927 E051 31.011356 0.0069428298 1.654527e-03 6.136358e-03 17 82449432 82449480 49 - 1.585 1.335 -0.858
ENSG00000178927 E052 46.265126 0.0011731766 1.487084e-02 4.019857e-02 17 82449481 82449714 234 - 1.679 1.529 -0.513
ENSG00000178927 E053 23.238695 0.0013017472 2.924090e-02 7.047120e-02 17 82449715 82449754 40 - 1.414 1.234 -0.629
ENSG00000178927 E054 31.908484 0.0227972014 1.021183e-01 1.937333e-01 17 82449755 82449900 146 - 1.533 1.370 -0.560
ENSG00000178927 E055 18.229147 0.0012431321 4.873649e-04 2.111844e-03 17 82449901 82449956 56 - 1.404 1.099 -1.076
ENSG00000178927 E056 34.987370 0.0154913715 3.178151e-04 1.452082e-03 17 82449957 82450198 242 - 1.686 1.370 -1.083
ENSG00000178927 E057 18.815635 0.0062984365 7.617813e-03 2.281875e-02 17 82450199 82450254 56 - 1.382 1.132 -0.878
ENSG00000178927 E058 13.193455 0.0058993644 4.850679e-03 1.551627e-02 17 82450255 82450278 24 - 1.267 0.970 -1.067
ENSG00000178927 E059 8.660773 0.0021621271 6.523284e-05 3.570589e-04 17 82450480 82450532 53 - 1.203 0.747 -1.707
ENSG00000178927 E060 11.565456 0.0018731927 1.503244e-07 1.475417e-06 17 82450533 82450699 167 - 1.359 0.831 -1.919
ENSG00000178927 E061 98.658814 0.0074788471 2.205268e-01 3.510357e-01 17 82450700 82450829 130 - 1.940 1.869 -0.237