ENSG00000178922

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372427 ENSG00000178922 HEK293_OSMI2_2hA HEK293_TMG_2hB HYI protein_coding retained_intron 20.14501 40.68362 11.63088 0.4653674 0.8986944 -1.805603 1.3446315 1.186196 0.9571606 0.20289100 0.09056143 -0.3066261 0.09571667 0.02906667 0.08236667 0.053300000 0.0001761845 0.0001761845 FALSE  
ENST00000372432 ENSG00000178922 HEK293_OSMI2_2hA HEK293_TMG_2hB HYI protein_coding protein_coding 20.14501 40.68362 11.63088 0.4653674 0.8986944 -1.805603 2.9245636 6.163772 1.6662208 0.29397641 0.29240826 -1.8809400 0.13142917 0.15140000 0.14576667 -0.005633333 0.9355777250 0.0001761845 FALSE  
ENST00000372434 ENSG00000178922 HEK293_OSMI2_2hA HEK293_TMG_2hB HYI protein_coding protein_coding 20.14501 40.68362 11.63088 0.4653674 0.8986944 -1.805603 1.2803480 3.054221 0.7942699 0.37834024 0.43471533 -1.9297688 0.06205417 0.07526667 0.06333333 -0.011933333 0.8110829323 0.0001761845 FALSE  
ENST00000470662 ENSG00000178922 HEK293_OSMI2_2hA HEK293_TMG_2hB HYI protein_coding protein_coding 20.14501 40.68362 11.63088 0.4653674 0.8986944 -1.805603 3.8478873 6.682036 2.0370314 1.46556621 0.93164767 -1.7089120 0.17922917 0.16416667 0.17336667 0.009200000 0.9894176508 0.0001761845 FALSE  
ENST00000487366 ENSG00000178922 HEK293_OSMI2_2hA HEK293_TMG_2hB HYI protein_coding protein_coding 20.14501 40.68362 11.63088 0.4653674 0.8986944 -1.805603 7.4703842 18.296058 3.2831941 0.80703088 0.72754392 -2.4747617 0.33927500 0.44980000 0.28550000 -0.164300000 0.1894998739 0.0001761845 FALSE  
ENST00000496142 ENSG00000178922 HEK293_OSMI2_2hA HEK293_TMG_2hB HYI protein_coding retained_intron 20.14501 40.68362 11.63088 0.4653674 0.8986944 -1.805603 0.5396981 0.102259 0.6849530 0.05477718 0.28162225 2.6300845 0.04668750 0.00250000 0.05826667 0.055766667 0.0002207103 0.0001761845    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178922 E001 4.8784490 0.0789289081 6.242173e-01 7.406143e-01 1 43450989 43451002 14 - 0.740 0.671 -0.286
ENSG00000178922 E002 6.1735227 0.1621298673 5.123734e-01 6.472770e-01 1 43451003 43451152 150 - 0.831 0.746 -0.336
ENSG00000178922 E003 0.8135738 0.0295491515 1.000000e+00 1.000000e+00 1 43451153 43451153 1 - 0.216 0.219 0.032
ENSG00000178922 E004 0.9952782 0.0122542489 8.194299e-01 8.859838e-01 1 43451154 43451157 4 - 0.216 0.261 0.357
ENSG00000178922 E005 1.9184484 0.0993438630 3.378868e-01 4.817614e-01 1 43451158 43451159 2 - 0.216 0.442 1.457
ENSG00000178922 E006 8.8709481 0.0039445114 3.452486e-01 4.893375e-01 1 43451160 43451165 6 - 0.788 0.916 0.494
ENSG00000178922 E007 168.7312542 0.0060974153 7.309945e-02 1.484868e-01 1 43451166 43451311 146 - 2.044 2.127 0.276
ENSG00000178922 E008 3.0925881 0.0052959536 8.094022e-02 1.610059e-01 1 43451312 43451319 8 - 0.740 0.449 -1.310
ENSG00000178922 E009 4.2372934 0.0045526645 9.681935e-03 2.797848e-02 1 43451320 43451409 90 - 0.907 0.520 -1.614
ENSG00000178922 E010 40.8320656 0.0005552138 8.660042e-01 9.177158e-01 1 43451410 43451427 18 - 1.503 1.509 0.021
ENSG00000178922 E011 305.5036172 0.0005155345 2.917219e-04 1.346109e-03 1 43451428 43451544 117 - 2.292 2.384 0.307
ENSG00000178922 E012 196.2298496 0.0002787499 4.961549e-03 1.582328e-02 1 43451648 43451666 19 - 2.106 2.192 0.289
ENSG00000178922 E013 276.9318406 0.0001604628 1.173235e-01 2.161279e-01 1 43451667 43451717 51 - 2.296 2.331 0.119
ENSG00000178922 E014 1.4620424 0.2242605441 9.215706e-01 9.544857e-01 1 43451718 43451740 23 - 0.358 0.329 -0.181
ENSG00000178922 E015 223.3481617 0.0004507041 4.387058e-01 5.805647e-01 1 43451798 43451827 30 - 2.219 2.237 0.061
ENSG00000178922 E016 213.4299414 0.0002486110 2.744600e-01 4.136124e-01 1 43451828 43451847 20 - 2.189 2.217 0.093
ENSG00000178922 E017 281.4872830 0.0002929540 4.633127e-01 6.031202e-01 1 43451935 43452013 79 - 2.321 2.334 0.046
ENSG00000178922 E018 4.8619318 0.0168423230 9.057046e-05 4.776943e-04 1 43452014 43452204 191 - 1.076 0.518 -2.249
ENSG00000178922 E019 289.2588667 0.0001758971 6.500378e-01 7.611390e-01 1 43452205 43452319 115 - 2.358 2.341 -0.056
ENSG00000178922 E020 41.0292494 0.0054902874 2.058741e-10 3.440564e-09 1 43452320 43452902 583 - 1.819 1.392 -1.456
ENSG00000178922 E021 46.2086609 0.0005920164 2.074423e-03 7.454773e-03 1 43452903 43453004 102 - 1.703 1.514 -0.645
ENSG00000178922 E022 14.5214426 0.0183024097 4.199232e-06 3.038701e-05 1 43453005 43453160 156 - 1.437 0.935 -1.792
ENSG00000178922 E023 9.7762066 0.0222248851 6.435571e-05 3.527470e-04 1 43453161 43453385 225 - 1.279 0.777 -1.852
ENSG00000178922 E024 96.9498680 0.0021601483 6.414319e-01 7.544709e-01 1 43453386 43453412 27 - 1.859 1.879 0.065
ENSG00000178922 E025 157.4137551 0.0021124991 1.908931e-01 3.148566e-01 1 43453413 43453497 85 - 2.125 2.067 -0.194
ENSG00000178922 E026 1.2586423 0.1341996077 2.370022e-01 3.707106e-01 1 43453498 43453594 97 - 0.467 0.223 -1.523
ENSG00000178922 E027 115.6538232 0.0127948497 2.384264e-02 5.948476e-02 1 43453595 43454732 1138 - 2.067 1.915 -0.509