ENSG00000178921

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314666 ENSG00000178921 HEK293_OSMI2_2hA HEK293_TMG_2hB PFAS protein_coding protein_coding 62.54509 78.42667 49.18809 4.508925 2.200507 -0.672926 38.293450 42.829963 28.7308397 6.4638796 0.21476244 -0.5758550 0.61479583 0.5407667 0.586900000 0.04613333 8.130770e-01 8.896487e-15 FALSE TRUE
ENST00000546020 ENSG00000178921 HEK293_OSMI2_2hA HEK293_TMG_2hB PFAS protein_coding protein_coding 62.54509 78.42667 49.18809 4.508925 2.200507 -0.672926 7.553301 17.082409 1.5917489 2.9394711 0.06321824 -3.4156359 0.10808750 0.2214000 0.032566667 -0.18883333 9.917824e-08 8.896487e-15 FALSE TRUE
ENST00000580251 ENSG00000178921 HEK293_OSMI2_2hA HEK293_TMG_2hB PFAS protein_coding retained_intron 62.54509 78.42667 49.18809 4.508925 2.200507 -0.672926 4.864095 2.911225 5.4491005 0.3317542 0.12514427 0.9020897 0.08355417 0.0369000 0.111200000 0.07430000 8.896487e-15 8.896487e-15   FALSE
ENST00000585319 ENSG00000178921 HEK293_OSMI2_2hA HEK293_TMG_2hB PFAS protein_coding processed_transcript 62.54509 78.42667 49.18809 4.508925 2.200507 -0.672926 1.195133 0.000000 4.6956419 0.0000000 2.41058557 8.8782477 0.02329583 0.0000000 0.091866667 0.09186667 1.394646e-01 8.896487e-15 FALSE FALSE
MSTRG.13621.10 ENSG00000178921 HEK293_OSMI2_2hA HEK293_TMG_2hB PFAS protein_coding   62.54509 78.42667 49.18809 4.508925 2.200507 -0.672926 3.527768 10.675330 0.3724295 0.4204468 0.20483447 -4.8042937 0.04810833 0.1375667 0.007833333 -0.12973333 7.675768e-03 8.896487e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178921 E001 10.5512117 1.710131e-03 3.786964e-02 8.710680e-02 17 8247618 8247856 239 + 1.148 0.956 -0.699
ENSG00000178921 E002 2.5410687 6.681211e-03 2.180712e-01 3.480861e-01 17 8249274 8249283 10 + 0.363 0.593 1.162
ENSG00000178921 E003 2.9838599 6.057816e-03 5.386535e-01 6.700611e-01 17 8249284 8249285 2 + 0.502 0.619 0.540
ENSG00000178921 E004 4.2361871 3.918453e-03 6.902740e-01 7.920051e-01 17 8249286 8249288 3 + 0.728 0.690 -0.160
ENSG00000178921 E005 4.2361871 3.918453e-03 6.902740e-01 7.920051e-01 17 8249289 8249290 2 + 0.728 0.690 -0.160
ENSG00000178921 E006 150.6122041 7.342828e-03 7.417036e-08 7.724767e-07 17 8249291 8249339 49 + 2.299 2.056 -0.814
ENSG00000178921 E007 0.9912127 1.615725e-01 5.277862e-01 6.607753e-01 17 8249342 8249505 164 + 0.157 0.302 1.209
ENSG00000178921 E008 2.0420522 2.117267e-01 5.575880e-01 6.859718e-01 17 8253842 8253858 17 + 0.364 0.502 0.731
ENSG00000178921 E009 247.0195613 2.764091e-03 3.517529e-11 6.695994e-10 17 8253859 8253937 79 + 2.486 2.288 -0.661
ENSG00000178921 E010 345.4169294 3.949491e-03 7.811787e-09 9.820954e-08 17 8253938 8254079 142 + 2.620 2.442 -0.592
ENSG00000178921 E011 275.6260469 2.932647e-03 1.777368e-04 8.684990e-04 17 8254166 8254301 136 + 2.474 2.374 -0.333
ENSG00000178921 E012 234.1079574 4.455795e-03 3.137753e-04 1.435875e-03 17 8255027 8255132 106 + 2.412 2.297 -0.385
ENSG00000178921 E013 286.8509151 2.001104e-03 6.407534e-06 4.451695e-05 17 8255502 8255691 190 + 2.496 2.386 -0.367
ENSG00000178921 E014 239.3905097 2.465895e-03 7.667257e-09 9.656553e-08 17 8255805 8255910 106 + 2.453 2.287 -0.555
ENSG00000178921 E015 356.1732293 1.435062e-03 3.444937e-09 4.623683e-08 17 8256267 8256407 141 + 2.603 2.473 -0.432
ENSG00000178921 E016 5.5085772 6.414987e-02 3.738902e-02 8.620747e-02 17 8256408 8256523 116 + 0.988 0.663 -1.273
ENSG00000178921 E017 349.3480677 5.138331e-04 2.012494e-09 2.814853e-08 17 8256524 8256648 125 + 2.579 2.471 -0.360
ENSG00000178921 E018 273.5434423 8.623303e-04 1.017249e-03 4.018491e-03 17 8256835 8256963 129 + 2.442 2.381 -0.203
ENSG00000178921 E019 277.6743480 1.536636e-03 1.230158e-01 2.242609e-01 17 8257807 8257938 132 + 2.422 2.403 -0.064
ENSG00000178921 E020 322.1963219 3.171045e-04 2.904537e-02 7.009450e-02 17 8258071 8258199 129 + 2.489 2.465 -0.081
ENSG00000178921 E021 0.0000000       17 8262460 8262499 40 +      
ENSG00000178921 E022 300.7276035 5.469178e-04 6.960651e-03 2.112042e-02 17 8262920 8262987 68 + 2.471 2.431 -0.133
ENSG00000178921 E023 194.2082701 1.955534e-04 1.847706e-01 3.071841e-01 17 8262988 8262993 6 + 2.263 2.250 -0.043
ENSG00000178921 E024 452.7784984 1.146402e-03 8.693010e-01 9.200053e-01 17 8263109 8263260 152 + 2.607 2.630 0.074
ENSG00000178921 E025 193.8449599 1.202234e-03 4.339392e-01 5.763391e-01 17 8263261 8263265 5 + 2.220 2.269 0.166
ENSG00000178921 E026 302.1344233 1.815652e-03 6.030529e-01 7.239042e-01 17 8263575 8263636 62 + 2.440 2.450 0.034
ENSG00000178921 E027 457.8572270 2.114644e-04 1.895951e-04 9.195421e-04 17 8263775 8263936 162 + 2.656 2.611 -0.149
ENSG00000178921 E028 325.7394634 1.412998e-03 1.565406e-02 4.196487e-02 17 8264212 8264337 126 + 2.505 2.465 -0.133
ENSG00000178921 E029 233.7688401 2.677563e-03 1.642582e-01 2.807085e-01 17 8264470 8264601 132 + 2.279 2.357 0.261
ENSG00000178921 E030 9.1613219 1.920158e-03 5.035715e-06 3.582161e-05 17 8264602 8264641 40 + 1.233 0.769 -1.725
ENSG00000178921 E031 467.0485246 1.950350e-04 2.582717e-01 3.955025e-01 17 8264895 8265125 231 + 2.602 2.647 0.149
ENSG00000178921 E032 508.6930423 1.447132e-04 1.257974e-01 2.282839e-01 17 8265288 8265468 181 + 2.635 2.685 0.168
ENSG00000178921 E033 346.1752625 1.583100e-04 9.980221e-01 1.000000e+00 17 8265556 8265639 84 + 2.489 2.512 0.078
ENSG00000178921 E034 406.3498983 1.370125e-04 9.781581e-01 9.904653e-01 17 8265862 8265972 111 + 2.557 2.581 0.080
ENSG00000178921 E035 238.6464926 2.962782e-04 4.940120e-01 6.310327e-01 17 8265973 8266005 33 + 2.340 2.346 0.020
ENSG00000178921 E036 209.5461515 2.084537e-04 8.578384e-02 1.686452e-01 17 8266006 8266017 12 + 2.302 2.280 -0.073
ENSG00000178921 E037 285.8175054 1.542435e-04 8.253207e-02 1.635029e-01 17 8266234 8266271 38 + 2.432 2.417 -0.053
ENSG00000178921 E038 406.8210064 1.066733e-03 6.572962e-01 7.666671e-01 17 8266272 8266353 82 + 2.551 2.588 0.120
ENSG00000178921 E039 9.3666795 2.052779e-03 2.783813e-02 6.769592e-02 17 8266501 8266752 252 + 1.120 0.906 -0.787
ENSG00000178921 E040 519.6302538 1.451414e-04 7.072237e-03 2.141407e-02 17 8266753 8266898 146 + 2.631 2.702 0.235
ENSG00000178921 E041 42.5214938 5.352706e-04 1.983508e-18 1.052871e-16 17 8266899 8267027 129 + 1.854 1.404 -1.533
ENSG00000178921 E042 645.2578597 5.486390e-04 4.406161e-03 1.428116e-02 17 8267028 8267226 199 + 2.720 2.798 0.260
ENSG00000178921 E043 249.5849880 1.432827e-03 6.421008e-01 7.549678e-01 17 8267227 8267235 9 + 2.336 2.375 0.130
ENSG00000178921 E044 467.4806299 8.997717e-04 1.023901e-01 1.941622e-01 17 8267372 8267463 92 + 2.592 2.654 0.207
ENSG00000178921 E045 506.2650696 6.804366e-04 1.665760e-01 2.837454e-01 17 8267551 8267665 115 + 2.632 2.686 0.180
ENSG00000178921 E046 695.4086477 9.322744e-05 1.016622e-08 1.251435e-07 17 8268533 8268856 324 + 2.729 2.838 0.365
ENSG00000178921 E047 12.9202125 1.886041e-02 4.258762e-01 5.687525e-01 17 8268857 8268953 97 + 1.148 1.082 -0.238
ENSG00000178921 E048 2564.8674278 5.184209e-03 2.372942e-10 3.922747e-09 17 8268954 8270491 1538 + 3.212 3.437 0.750