ENSG00000178752

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344233 ENSG00000178752 HEK293_OSMI2_2hA HEK293_TMG_2hB ERFE protein_coding protein_coding 21.89427 32.86249 18.69201 0.7029598 0.7610998 -0.8136872 5.9585748 9.869339 2.8161678 2.1522753 0.2901083 -1.8055674 0.26057917 0.29870000 0.152266667 -0.146433333 0.1640412380 3.273955e-05   FALSE
ENST00000357303 ENSG00000178752 HEK293_OSMI2_2hA HEK293_TMG_2hB ERFE protein_coding protein_coding 21.89427 32.86249 18.69201 0.7029598 0.7610998 -0.8136872 7.1349134 10.973625 5.6853836 0.1761505 0.4165257 -0.9474893 0.33314167 0.33403333 0.304033333 -0.030000000 0.6208190661 3.273955e-05 FALSE TRUE
ENST00000473274 ENSG00000178752 HEK293_OSMI2_2hA HEK293_TMG_2hB ERFE protein_coding retained_intron 21.89427 32.86249 18.69201 0.7029598 0.7610998 -0.8136872 1.8943670 4.034631 2.2771885 1.1725438 0.5873134 -0.8224330 0.09460000 0.12440000 0.119766667 -0.004633333 1.0000000000 3.273955e-05 FALSE TRUE
ENST00000546354 ENSG00000178752 HEK293_OSMI2_2hA HEK293_TMG_2hB ERFE protein_coding protein_coding 21.89427 32.86249 18.69201 0.7029598 0.7610998 -0.8136872 1.8042249 1.447792 1.2327537 1.4477916 0.6205635 -0.2302441 0.07252500 0.04246667 0.068733333 0.026266667 0.5192510206 3.273955e-05 FALSE TRUE
MSTRG.20132.1 ENSG00000178752 HEK293_OSMI2_2hA HEK293_TMG_2hB ERFE protein_coding   21.89427 32.86249 18.69201 0.7029598 0.7610998 -0.8136872 2.6502329 2.304673 4.8747822 0.4993801 0.9078347 1.0774860 0.11870417 0.07043333 0.258266667 0.187833333 0.0006459625 3.273955e-05 FALSE TRUE
MSTRG.20132.5 ENSG00000178752 HEK293_OSMI2_2hA HEK293_TMG_2hB ERFE protein_coding   21.89427 32.86249 18.69201 0.7029598 0.7610998 -0.8136872 0.5970157 2.643859 0.1436477 1.1919960 0.1436477 -4.1103937 0.02389167 0.08206667 0.007966667 -0.074100000 0.1304709829 3.273955e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178752 E001 5.2619144 0.0155911814 1.116906e-06 9.179808e-06 2 238158933 238158969 37 + 1.099 0.405 -2.908
ENSG00000178752 E002 7.0991737 0.0138762329 2.943790e-09 4.001440e-08 2 238158970 238158981 12 + 1.233 0.447 -3.162
ENSG00000178752 E003 18.1715141 0.0619492900 1.917467e-08 2.243998e-07 2 238158982 238159135 154 + 1.617 0.779 -3.010
ENSG00000178752 E004 13.8015539 0.0289867583 3.810977e-05 2.207952e-04 2 238159136 238159152 17 + 1.397 0.905 -1.765
ENSG00000178752 E005 26.8484371 0.0137382393 1.450536e-02 3.937523e-02 2 238159153 238159205 53 + 1.542 1.332 -0.724
ENSG00000178752 E006 72.5856949 0.0062813282 1.368582e-01 2.437105e-01 2 238161594 238161716 123 + 1.889 1.810 -0.268
ENSG00000178752 E007 70.8445219 0.0093677924 8.341461e-01 8.961341e-01 2 238162736 238162838 103 + 1.832 1.825 -0.023
ENSG00000178752 E008 2.7345056 0.0055550020 9.153037e-02 1.775218e-01 2 238163642 238163736 95 + 0.710 0.446 -1.204
ENSG00000178752 E009 82.4284190 0.0087017868 3.825770e-04 1.707294e-03 2 238163737 238163991 255 + 2.013 1.814 -0.670
ENSG00000178752 E010 26.1335953 0.0115306254 4.699426e-05 2.665625e-04 2 238163992 238163999 8 + 1.595 1.257 -1.168
ENSG00000178752 E011 0.8836079 0.0139525481 1.432298e-03 5.414592e-03 2 238164000 238164027 28 + 0.541 0.000 -12.591
ENSG00000178752 E012 1.3296214 0.0108623590 7.281384e-05 3.937084e-04 2 238164028 238164074 47 + 0.674 0.000 -13.218
ENSG00000178752 E013 59.3202732 0.0113875642 1.237332e-03 4.767024e-03 2 238164075 238164179 105 + 1.880 1.668 -0.714
ENSG00000178752 E014 29.0945113 0.0092126872 7.069176e-01 8.049782e-01 2 238164180 238164183 4 + 1.464 1.438 -0.090
ENSG00000178752 E015 1.7337133 0.0125246266 2.859819e-01 4.263531e-01 2 238164184 238164269 86 + 0.541 0.358 -0.954
ENSG00000178752 E016 66.1207514 0.0009429963 2.605483e-01 3.980910e-01 2 238164270 238164332 63 + 1.829 1.779 -0.172
ENSG00000178752 E017 65.1276646 0.0004203786 2.278372e-01 3.598421e-01 2 238164333 238164360 28 + 1.829 1.776 -0.181
ENSG00000178752 E018 9.8702189 0.0017758390 2.222265e-05 1.363347e-04 2 238164361 238164726 366 + 1.244 0.805 -1.618
ENSG00000178752 E019 4.1415719 0.0403330733 3.489519e-03 1.169513e-02 2 238165593 238165605 13 + 0.947 0.482 -1.948
ENSG00000178752 E020 106.5110106 0.0003302643 4.233477e-02 9.533325e-02 2 238165606 238165684 79 + 2.051 1.982 -0.234
ENSG00000178752 E021 389.5199657 0.0005384017 4.524182e-04 1.976188e-03 2 238166956 238167871 916 + 2.520 2.588 0.227
ENSG00000178752 E022 169.8463879 0.0002932672 1.803615e-07 1.743847e-06 2 238167872 238168085 214 + 2.100 2.251 0.506
ENSG00000178752 E023 190.4209170 0.0004684085 5.629703e-06 3.960821e-05 2 238168086 238168370 285 + 2.167 2.293 0.423
ENSG00000178752 E024 384.8778009 0.0069427745 1.220395e-03 4.709721e-03 2 238168371 238168900 530 + 2.476 2.601 0.416