ENSG00000178741

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000564811 ENSG00000178741 HEK293_OSMI2_2hA HEK293_TMG_2hB COX5A protein_coding protein_coding 539.0258 866.0352 387.6896 59.79991 14.7279 -1.159503 91.30646 87.05543 118.45115 34.096347 13.257559 0.44424202 0.17646250 0.10406667 0.30396667 0.19990000 0.1234657317 0.0001509419 FALSE TRUE
ENST00000567270 ENSG00000178741 HEK293_OSMI2_2hA HEK293_TMG_2hB COX5A protein_coding protein_coding 539.0258 866.0352 387.6896 59.79991 14.7279 -1.159503 41.43519 75.77454 19.26755 8.602087 2.282820 -1.97498152 0.07012917 0.08693333 0.04936667 -0.03756667 0.0004468697 0.0001509419 FALSE TRUE
MSTRG.11214.2 ENSG00000178741 HEK293_OSMI2_2hA HEK293_TMG_2hB COX5A protein_coding   539.0258 866.0352 387.6896 59.79991 14.7279 -1.159503 344.87359 612.44879 196.71483 65.914230 5.945221 -1.63843371 0.63970833 0.70436667 0.51010000 -0.19426667 0.0263676455 0.0001509419 TRUE TRUE
MSTRG.11214.7 ENSG00000178741 HEK293_OSMI2_2hA HEK293_TMG_2hB COX5A protein_coding   539.0258 866.0352 387.6896 59.79991 14.7279 -1.159503 27.97955 29.96639 31.47091 2.494661 5.294331 0.07065072 0.05423333 0.03456667 0.08046667 0.04590000 0.0001509419 0.0001509419 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178741 E001 2.8452083 0.0299883340 8.407371e-03 2.480650e-02 15 74918812 74918833 22 - 0.825 0.364 -2.119
ENSG00000178741 E002 4.4057501 0.0284070454 1.073692e-03 4.213547e-03 15 74918834 74918943 110 - 1.005 0.485 -2.150
ENSG00000178741 E003 190.4444668 0.0013947652 2.682469e-01 4.066885e-01 15 74919791 74920270 480 - 2.252 2.188 -0.212
ENSG00000178741 E004 52.6650480 0.0004514134 1.973466e-01 3.229128e-01 15 74920271 74920274 4 - 1.722 1.626 -0.326
ENSG00000178741 E005 108.2586672 0.0061392178 4.318989e-06 3.117264e-05 15 74920275 74920279 5 - 1.750 2.002 0.849
ENSG00000178741 E006 146.7003772 0.0042358279 7.886546e-08 8.171977e-07 15 74920280 74920311 32 - 1.885 2.132 0.829
ENSG00000178741 E007 140.1222538 0.0139146259 3.868302e-06 2.823930e-05 15 74920312 74920317 6 - 1.807 2.117 1.041
ENSG00000178741 E008 3410.3413084 0.0033522273 3.799832e-04 1.697252e-03 15 74920318 74920442 125 - 3.396 3.459 0.211
ENSG00000178741 E009 6.3355970 0.0031237146 3.782995e-01 5.225803e-01 15 74923594 74923647 54 - 0.894 0.753 -0.552
ENSG00000178741 E010 5682.6863499 0.0030646979 2.358327e-03 8.333546e-03 15 74923648 74923770 123 - 3.639 3.676 0.122
ENSG00000178741 E011 5594.7055800 0.0004052529 2.830347e-07 2.633341e-06 15 74926766 74926887 122 - 3.650 3.666 0.054
ENSG00000178741 E012 4647.4115158 0.0020211604 1.605256e-03 5.978079e-03 15 74929116 74929232 117 - 3.653 3.559 -0.312
ENSG00000178741 E013 5.3571296 0.0425241120 7.345196e-01 8.254490e-01 15 74937688 74937914 227 - 0.787 0.708 -0.318
ENSG00000178741 E014 2944.5145141 0.0102193161 3.467488e-04 1.567157e-03 15 74937915 74938036 122 - 3.528 3.333 -0.651
ENSG00000178741 E015 496.6676584 0.0286772358 9.115362e-05 4.804624e-04 15 74938037 74938126 90 - 2.867 2.503 -1.212
ENSG00000178741 E016 12.2725249 0.0043700681 3.115610e-08 3.493388e-07 15 74938400 74938720 321 - 1.416 0.854 -2.028
ENSG00000178741 E017 0.2998086 0.0290097800 4.401228e-01   15 74938804 74939088 285 - 0.196 0.074 -1.615
ENSG00000178741 E018 4.4487955 2.8966065578 8.018089e-01 8.737178e-01 15 74939250 74939292 43 - 0.001 0.753 11.113