ENSG00000178719

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313269 ENSG00000178719 HEK293_OSMI2_2hA HEK293_TMG_2hB GRINA protein_coding protein_coding 141.9666 242.4343 101.1593 9.32314 2.872307 -1.260882 6.310522 6.87884 8.3103193 1.3646444 0.05354127 0.2723779 0.04501250 0.02836667 0.082300000 0.05393333 3.542514e-04 2.988632e-15 FALSE TRUE
ENST00000395068 ENSG00000178719 HEK293_OSMI2_2hA HEK293_TMG_2hB GRINA protein_coding protein_coding 141.9666 242.4343 101.1593 9.32314 2.872307 -1.260882 49.704713 71.61650 44.2556040 14.6631629 2.36835506 -0.6943073 0.34575417 0.29560000 0.436933333 0.14133333 2.537278e-01 2.988632e-15 FALSE TRUE
ENST00000533377 ENSG00000178719 HEK293_OSMI2_2hA HEK293_TMG_2hB GRINA protein_coding retained_intron 141.9666 242.4343 101.1593 9.32314 2.872307 -1.260882 4.743280 18.78734 0.0000000 6.4500511 0.00000000 -10.8763129 0.02114583 0.07736667 0.000000000 -0.07736667 2.988632e-15 2.988632e-15 FALSE TRUE
ENST00000534791 ENSG00000178719 HEK293_OSMI2_2hA HEK293_TMG_2hB GRINA protein_coding protein_coding 141.9666 242.4343 101.1593 9.32314 2.872307 -1.260882 10.092061 10.62323 9.7155688 0.5989375 1.24995469 -0.1287258 0.08269583 0.04380000 0.095833333 0.05203333 1.413305e-04 2.988632e-15 FALSE TRUE
MSTRG.32239.4 ENSG00000178719 HEK293_OSMI2_2hA HEK293_TMG_2hB GRINA protein_coding   141.9666 242.4343 101.1593 9.32314 2.872307 -1.260882 58.503482 109.45628 35.4968922 5.2278222 2.26321603 -1.6243156 0.39888333 0.45216667 0.351400000 -0.10076667 9.849978e-02 2.988632e-15 FALSE FALSE
MSTRG.32239.7 ENSG00000178719 HEK293_OSMI2_2hA HEK293_TMG_2hB GRINA protein_coding   141.9666 242.4343 101.1593 9.32314 2.872307 -1.260882 6.972923 13.66355 0.2111174 13.6635491 0.21111738 -5.9504315 0.06747083 0.05706667 0.001966667 -0.05510000 9.768436e-01 2.988632e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178719 E001 0.6213751 0.0197588988 7.047186e-02 1.441198e-01 8 143990056 143990057 2 + 0.384 0.088 -2.673
ENSG00000178719 E002 1.0934249 0.2350753559 7.768632e-02 1.557450e-01 8 143990058 143990064 7 + 0.527 0.161 -2.398
ENSG00000178719 E003 3.8487579 0.1463175480 6.257951e-03 1.928976e-02 8 143990065 143990065 1 + 0.956 0.415 -2.331
ENSG00000178719 E004 13.0929992 0.0307074400 4.802468e-08 5.201310e-07 8 143990066 143990082 17 + 1.448 0.809 -2.312
ENSG00000178719 E005 198.3370143 0.0238882048 5.084488e-04 2.191376e-03 8 143990083 143990199 117 + 2.406 2.173 -0.778
ENSG00000178719 E006 37.2992438 0.0019516357 6.460475e-16 2.502387e-14 8 143990200 143990286 87 + 1.807 1.351 -1.556
ENSG00000178719 E007 33.0825365 0.0040307316 5.359339e-08 5.739137e-07 8 143990287 143990311 25 + 1.694 1.357 -1.154
ENSG00000178719 E008 0.7427016 0.0154468375 1.170875e-03 4.541837e-03 8 143990441 143990486 46 + 0.528 0.000 -11.672
ENSG00000178719 E009 1.7233302 0.0382329384 5.522117e-01 6.815256e-01 8 143990677 143990907 231 + 0.462 0.370 -0.496
ENSG00000178719 E010 340.1193012 0.0071425884 4.377203e-03 1.419775e-02 8 143991200 143991293 94 + 2.550 2.456 -0.315
ENSG00000178719 E011 409.3445069 0.0043913793 4.157789e-01 5.591304e-01 8 143991294 143991453 160 + 2.563 2.565 0.008
ENSG00000178719 E012 248.9095389 0.0025380088 3.269372e-01 4.703848e-01 8 143991454 143991532 79 + 2.301 2.367 0.220
ENSG00000178719 E013 194.0620856 0.0002451012 3.134027e-01 4.559909e-01 8 143991533 143991555 23 + 2.239 2.241 0.008
ENSG00000178719 E014 432.6347047 0.0001439929 2.567166e-05 1.551924e-04 8 143991556 143991602 47 + 2.623 2.575 -0.159
ENSG00000178719 E015 4.1382954 0.1084676372 1.121418e-02 3.168046e-02 8 143991603 143991691 89 + 0.934 0.485 -1.886
ENSG00000178719 E016 729.2597032 0.0006265326 4.275632e-03 1.391595e-02 8 143991692 143991746 55 + 2.831 2.811 -0.065
ENSG00000178719 E017 996.8755849 0.0001710438 2.740226e-06 2.069639e-05 8 143991747 143991804 58 + 2.972 2.942 -0.100
ENSG00000178719 E018 13.4327394 0.0037388527 1.485531e-03 5.589795e-03 8 143991805 143991877 73 + 1.290 1.016 -0.980
ENSG00000178719 E019 1173.7264972 0.0011622712 8.715544e-05 4.616619e-04 8 143991878 143991949 72 + 3.053 3.011 -0.139
ENSG00000178719 E020 843.5891273 0.0014057939 4.930965e-06 3.513716e-05 8 143991950 143991955 6 + 2.926 2.859 -0.223
ENSG00000178719 E021 1767.4954302 0.0002973794 2.665348e-05 1.605080e-04 8 143991956 143992078 123 + 3.210 3.194 -0.052
ENSG00000178719 E022 71.2199136 0.0003958182 1.396806e-13 3.888052e-12 8 143992079 143992173 95 + 1.995 1.708 -0.967
ENSG00000178719 E023 62.4392539 0.0003952181 4.435718e-09 5.834434e-08 8 143992174 143992244 71 + 1.910 1.670 -0.809
ENSG00000178719 E024 1745.7988713 0.0002631971 7.012311e-01 8.004804e-01 8 143992245 143992373 129 + 3.173 3.201 0.093
ENSG00000178719 E025 2115.2053932 0.0003279551 2.948039e-04 1.358741e-03 8 143992465 143992608 144 + 3.223 3.296 0.245
ENSG00000178719 E026 3683.1733143 0.0021296711 7.897120e-18 3.929828e-16 8 143992692 143993415 724 + 3.368 3.567 0.659