ENSG00000178691

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322652 ENSG00000178691 HEK293_OSMI2_2hA HEK293_TMG_2hB SUZ12 protein_coding protein_coding 11.99581 3.543448 21.00261 0.3555962 0.7948593 2.563964 10.1285997 1.57798687 19.2454729 0.46656465 0.6152294 3.599998 0.74897083 0.4476000 0.916733333 0.4691333 3.854595e-05 4.283821e-11 FALSE TRUE
ENST00000578106 ENSG00000178691 HEK293_OSMI2_2hA HEK293_TMG_2hB SUZ12 protein_coding retained_intron 11.99581 3.543448 21.00261 0.3555962 0.7948593 2.563964 0.5120193 1.70291815 0.0443024 0.29813549 0.0443024 -4.979296 0.15440417 0.4794667 0.002033333 -0.4774333 4.283821e-11 4.283821e-11 FALSE TRUE
ENST00000580398 ENSG00000178691 HEK293_OSMI2_2hA HEK293_TMG_2hB SUZ12 protein_coding protein_coding 11.99581 3.543448 21.00261 0.3555962 0.7948593 2.563964 1.0754071 0.09787357 1.4676249 0.09787357 0.3214301 3.775867 0.06926667 0.0259000 0.068900000 0.0430000 3.560381e-01 4.283821e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178691 E001 12.2554630 0.0014218380 6.387445e-01 7.523300e-01 17 31937007 31937066 60 + 0.903 0.993 0.336
ENSG00000178691 E002 94.5167062 0.0003425798 7.114039e-04 2.939504e-03 17 31937067 31937520 454 + 1.754 1.724 -0.101
ENSG00000178691 E003 57.5965833 0.0005771536 3.668267e-03 1.220546e-02 17 31940286 31940332 47 + 1.544 1.489 -0.190
ENSG00000178691 E004 62.4018211 0.0004248660 2.685615e-04 1.251739e-03 17 31940422 31940486 65 + 1.583 1.473 -0.377
ENSG00000178691 E005 55.2019082 0.0004120045 2.016733e-05 1.249678e-04 17 31947617 31947685 69 + 1.539 1.342 -0.677
ENSG00000178691 E006 0.7469680 0.0169286597 7.061565e-01 8.043535e-01 17 31965695 31966146 452 + 0.170 0.000 -9.265
ENSG00000178691 E007 61.7470377 0.0003783853 2.904328e-05 1.733893e-04 17 31966147 31966196 50 + 1.584 1.422 -0.558
ENSG00000178691 E008 0.1451727 0.0429995300 7.206981e-01   17 31966197 31967589 1393 + 0.040 0.000 -6.942
ENSG00000178691 E009 85.9893169 0.0003985911 1.367378e-07 1.353284e-06 17 31973146 31973231 86 + 1.726 1.533 -0.657
ENSG00000178691 E010 149.5548864 0.0002585702 6.975787e-09 8.852773e-08 17 31975482 31975713 232 + 1.957 1.842 -0.388
ENSG00000178691 E011 99.0038531 0.0002836439 1.487469e-04 7.415895e-04 17 31976521 31976614 94 + 1.775 1.724 -0.174
ENSG00000178691 E012 102.9605015 0.0002876637 1.040432e-05 6.889433e-05 17 31982999 31983104 106 + 1.794 1.705 -0.301
ENSG00000178691 E013 128.3093091 0.0002501046 6.115043e-04 2.575251e-03 17 31988320 31988497 178 + 1.880 1.882 0.005
ENSG00000178691 E014 73.9132750 0.0009370542 4.081379e-03 1.337139e-02 17 31993242 31993333 92 + 1.647 1.622 -0.084
ENSG00000178691 E015 95.8530233 0.0003365546 2.863050e-04 1.324145e-03 17 31993865 31994008 144 + 1.759 1.715 -0.152
ENSG00000178691 E016 0.3030308 0.3766833049 1.000000e+00   17 31994353 31994563 211 + 0.077 0.000 -7.950
ENSG00000178691 E017 126.6921464 0.0023270296 1.740845e-03 6.411186e-03 17 31994564 31994721 158 + 1.875 1.876 0.002
ENSG00000178691 E018 153.1993808 0.0003883038 1.530277e-02 4.117404e-02 17 31995564 31995762 199 + 1.950 2.016 0.222
ENSG00000178691 E019 86.0373593 0.0003265652 3.467127e-01 4.908398e-01 17 31996798 31996877 80 + 1.682 1.906 0.757
ENSG00000178691 E020 622.6170421 0.0175601646 8.722884e-13 2.163273e-11 17 31998658 32001038 2381 + 2.485 2.974 1.625