ENSG00000178685

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313028 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding protein_coding 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.158148899 0.39244522 0.00000000 0.02205507 0.00000000 -5.3307205 0.259829167 0.57743333 0.00000000 -0.57743333 5.587659e-05 5.587659e-05 FALSE TRUE
ENST00000524918 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding protein_coding 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.029480774 0.00000000 0.05850506 0.00000000 0.05850506 2.7762105 0.073308333 0.00000000 0.14970000 0.14970000 6.888927e-01 5.587659e-05 FALSE TRUE
ENST00000525773 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding protein_coding 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.011156869 0.00000000 0.07584130 0.00000000 0.04100854 3.1016720 0.032854167 0.00000000 0.20133333 0.20133333 1.053027e-01 5.587659e-05 FALSE TRUE
ENST00000525879 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding protein_coding 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.028443800 0.00000000 0.09230936 0.00000000 0.06400893 3.3548662 0.076937500 0.00000000 0.25936667 0.25936667 2.153807e-01 5.587659e-05 FALSE FALSE
ENST00000526007 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding retained_intron 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.040832349 0.03676732 0.05290395 0.03676732 0.03653277 0.4276499 0.101545833 0.03770000 0.17513333 0.13743333 7.122325e-01 5.587659e-05 TRUE FALSE
ENST00000527262 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding nonsense_mediated_decay 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.038446288 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.129233333 0.00000000 0.00000000 0.00000000   5.587659e-05 TRUE TRUE
ENST00000528136 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding protein_coding 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.026014088 0.09596486 0.01503277 0.01966210 0.01503277 -2.0816962 0.060000000 0.15043333 0.03036667 -0.12006667 4.204026e-01 5.587659e-05 FALSE FALSE
ENST00000528580 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding retained_intron 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.006830538 0.05464430 0.00000000 0.05464430 0.00000000 -2.6925232 0.007000000 0.05600000 0.00000000 -0.05600000 8.240720e-01 5.587659e-05   FALSE
ENST00000528963 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding retained_intron 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.029030602 0.00000000 0.04206281 0.00000000 0.04206281 2.3802531 0.056812500 0.00000000 0.08493333 0.08493333 6.049195e-01 5.587659e-05 FALSE TRUE
ENST00000530478 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding protein_coding 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.004662013 0.03729610 0.00000000 0.03729610 0.00000000 -2.2417213 0.007170833 0.05736667 0.00000000 -0.05736667 8.669536e-01 5.587659e-05   FALSE
ENST00000531707 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding protein_coding 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.038972126 0.08952719 0.00000000 0.08952719 0.00000000 -3.3150907 0.076804167 0.09176667 0.00000000 -0.09176667 8.350069e-01 5.587659e-05 TRUE FALSE
ENST00000532660 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding processed_transcript 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.030347181 0.01586280 0.00000000 0.01586280 0.00000000 -1.3708782 0.086466667 0.02930000 0.00000000 -0.02930000 8.699884e-01 5.587659e-05   FALSE
ENST00000533665 ENSG00000178685 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP10 protein_coding processed_transcript 0.4608942 0.7225078 0.3857789 0.1303554 0.06465462 -0.8881495 0.006140455 0.00000000 0.04912364 0.00000000 0.04912364 2.5637350 0.012400000 0.00000000 0.09920000 0.09920000 6.219280e-01 5.587659e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178685 E001 0.0000000       8 143977153 143977157 5 -      
ENSG00000178685 E002 0.9264943 0.017213368 0.3448128633 0.488910064 8 143977158 143977382 225 - 0.383 0.224 -1.070
ENSG00000178685 E003 2.1359430 0.009234295 0.6278457357 0.743531584 8 143977383 143977452 70 - 0.383 0.481 0.520
ENSG00000178685 E004 5.1595569 0.003615506 0.5640827872 0.691455731 8 143977453 143977830 378 - 0.678 0.774 0.392
ENSG00000178685 E005 3.0183999 0.005746056 0.0009086982 0.003644315 8 143977907 143978081 175 - 0.000 0.663 14.685
ENSG00000178685 E006 4.2801772 0.004557949 0.0963651301 0.184909195 8 143982932 143983065 134 - 0.460 0.740 1.256
ENSG00000178685 E007 3.2847999 0.005210456 0.6248117326 0.741056446 8 143983167 143983311 145 - 0.526 0.618 0.418
ENSG00000178685 E008 5.2167892 0.003615506 0.8584815232 0.912689525 8 143983312 143983811 500 - 0.719 0.758 0.157
ENSG00000178685 E009 0.5901394 0.169999407 0.9761429717 0.989080316 8 143983812 143983841 30 - 0.168 0.164 -0.034
ENSG00000178685 E010 0.7373885 0.275791284 0.5402811887 0.671437804 8 143983842 143984007 166 - 0.288 0.166 -1.016
ENSG00000178685 E011 1.9821384 0.166196521 0.9572903929 0.977227280 8 143984008 143984034 27 - 0.460 0.445 -0.076
ENSG00000178685 E012 2.4176564 0.013458491 0.2292962180 0.361597914 8 143984035 143984104 70 - 0.633 0.447 -0.875
ENSG00000178685 E013 0.1515154 0.047557652 0.2208711933   8 143984105 143984209 105 - 0.168 0.000 -13.815
ENSG00000178685 E014 4.3278984 0.032771677 0.4393899922 0.581138496 8 143984210 143984431 222 - 0.583 0.723 0.601
ENSG00000178685 E015 4.3447223 0.003983970 0.0737609490 0.149543471 8 143984544 143984727 184 - 0.460 0.757 1.325
ENSG00000178685 E016 4.6058343 0.004760696 0.0447847005 0.099814439 8 143984728 143984982 255 - 0.460 0.790 1.455
ENSG00000178685 E017 5.0340552 0.003653675 0.3141564894 0.456841994 8 143984983 143985328 346 - 0.823 0.703 -0.482
ENSG00000178685 E018 2.6089101 0.006242785 0.6842954865 0.787286395 8 143985412 143985491 80 - 0.460 0.541 0.393
ENSG00000178685 E019 1.7650456 0.008357702 0.4170531851 0.560434354 8 143985492 143985549 58 - 0.288 0.447 0.934
ENSG00000178685 E020 0.7393776 0.492319578 0.7330712673 0.824378813 8 143985550 143985568 19 - 0.288 0.214 -0.564
ENSG00000178685 E021 1.5112214 0.014400994 0.9104261963 0.947035136 8 143985569 143985648 80 - 0.383 0.371 -0.068
ENSG00000178685 E022 0.0000000       8 143985649 143985717 69 -      
ENSG00000178685 E023 0.0000000       8 143985718 143985720 3 -      
ENSG00000178685 E024 0.5901394 0.169999407 0.9761429717 0.989080316 8 143985721 143985723 3 - 0.168 0.164 -0.034
ENSG00000178685 E025 0.5901394 0.169999407 0.9761429717 0.989080316 8 143985724 143985724 1 - 0.168 0.164 -0.034
ENSG00000178685 E026 0.8836053 0.015467765 0.6882931625 0.790464498 8 143985725 143985749 25 - 0.288 0.224 -0.480
ENSG00000178685 E027 0.8104533 0.016002600 0.6876325929 0.789931248 8 143985750 143985770 21 - 0.288 0.224 -0.483
ENSG00000178685 E028 0.9222279 0.014120232 0.3470589151 0.491227075 8 143985771 143985836 66 - 0.383 0.224 -1.069
ENSG00000178685 E029 0.8470867 0.014845457 0.1917532153 0.315961760 8 143985837 143985848 12 - 0.383 0.161 -1.650
ENSG00000178685 E030 1.5082027 0.010007191 0.0311073220 0.074114178 8 143985849 143985890 42 - 0.583 0.224 -2.065
ENSG00000178685 E031 1.2094382 0.012962006 0.1651012168 0.281831397 8 143985891 143985907 17 - 0.460 0.224 -1.479
ENSG00000178685 E032 0.8825612 0.016937583 0.1942206498 0.319056211 8 143985908 143985913 6 - 0.383 0.162 -1.649
ENSG00000178685 E033 2.0638101 0.007223693 0.8881920176 0.932541305 8 143985914 143985975 62 - 0.460 0.447 -0.067
ENSG00000178685 E034 0.2214452 0.038032034 1.0000000000   8 143985976 143986054 79 - 0.000 0.088 11.211
ENSG00000178685 E035 2.9904036 0.007661717 0.8643192054 0.916535205 8 143986055 143986233 179 - 0.526 0.568 0.197
ENSG00000178685 E036 0.1515154 0.047557652 0.2208711933   8 143986234 143986356 123 - 0.168 0.000 -13.815
ENSG00000178685 E037 0.1515154 0.047557652 0.2208711933   8 143986357 143986357 1 - 0.168 0.000 -13.815
ENSG00000178685 E038 1.8874163 0.011199399 0.7721647829 0.852924929 8 143986358 143986362 5 - 0.383 0.447 0.347
ENSG00000178685 E039 2.7323249 0.009119855 0.5804218623 0.705169403 8 143986363 143986435 73 - 0.460 0.568 0.517
ENSG00000178685 E040 0.9921577 0.012931248 0.9214429863 0.954416651 8 143986436 143986438 3 - 0.288 0.278 -0.068
ENSG00000178685 E041 0.0000000       8 143986439 143986460 22 -      
ENSG00000178685 E042 0.4428904 0.334620827 0.6124328294 0.731363857 8 143986755 143986914 160 - 0.000 0.167 12.036
ENSG00000178685 E043 0.4428904 0.334620827 0.6124328294 0.731363857 8 143986915 143987078 164 - 0.000 0.167 12.036
ENSG00000178685 E044 0.0000000       8 143987079 143987135 57 -      
ENSG00000178685 E045 0.0000000       8 143987136 143987181 46 -      
ENSG00000178685 E046 0.0000000       8 143988836 143988965 130 -      
ENSG00000178685 E047 2.7206873 0.005958648 0.0657643581 0.136306964 8 143989517 143990176 660 - 0.719 0.447 -1.238
ENSG00000178685 E048 1.8788991 0.012004671 0.0579446136 0.123112321 8 143990177 143990269 93 - 0.633 0.327 -1.554
ENSG00000178685 E049 1.4371390 0.009833659 0.4134290892 0.556919286 8 143990606 143991032 427 - 0.460 0.327 -0.747
ENSG00000178685 E050 0.0000000       8 143991033 143991188 156 -      
ENSG00000178685 E051 0.1817044 0.041569189 1.0000000000   8 144012530 144012772 243 - 0.000 0.088 11.208