ENSG00000178605

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326153 ENSG00000178605 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP6 protein_coding protein_coding 74.75951 135.9227 40.95662 8.833037 0.7183622 -1.730372 55.795671 105.055038 28.26960 6.0886908 1.5399059 -1.8934492 0.7305500 0.77370000 0.68983333 -0.08386667 1.644304e-01 1.255625e-07 FALSE  
ENST00000485332 ENSG00000178605 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP6 protein_coding retained_intron 74.75951 135.9227 40.95662 8.833037 0.7183622 -1.730372 6.420775 6.663986 5.30058 0.4326878 0.5223476 -0.3296792 0.1030333 0.04933333 0.12950000 0.08016667 1.591837e-06 1.255625e-07 FALSE  
MSTRG.33832.6 ENSG00000178605 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP6 protein_coding   74.75951 135.9227 40.95662 8.833037 0.7183622 -1.730372 4.656173 13.895822 3.23862 2.6057973 0.4059726 -2.0977902 0.0522625 0.10113333 0.07883333 -0.02230000 5.629084e-01 1.255625e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178605 E001 15.0017576 1.215639e-03 6.782751e-01 7.827891e-01 X 303454 303456 3 - 1.053 1.097 0.159
ENSG00000178605 E002 24.4071340 8.095343e-04 5.028286e-01 6.388316e-01 X 303457 303542 86 - 1.233 1.292 0.207
ENSG00000178605 E003 8.9517287 2.650090e-02 6.330871e-01 7.478454e-01 X 304401 304444 44 - 0.833 0.906 0.280
ENSG00000178605 E004 12.1057414 1.794932e-03 4.730692e-01 6.120772e-01 X 304445 304504 60 - 1.077 0.995 -0.303
ENSG00000178605 E005 10.8969577 4.157011e-02 4.776581e-01 6.161753e-01 X 304505 304511 7 - 1.053 0.949 -0.385
ENSG00000178605 E006 52.7033797 4.979622e-04 1.131284e-01 2.100934e-01 X 304512 304528 17 - 1.687 1.593 -0.322
ENSG00000178605 E007 95.4326048 6.729688e-04 2.499453e-03 8.761313e-03 X 304529 304533 5 - 1.969 1.833 -0.456
ENSG00000178605 E008 262.3740053 1.471007e-03 8.920840e-02 1.739229e-01 X 304534 304749 216 - 2.340 2.286 -0.180
ENSG00000178605 E009 1702.5231772 1.244051e-03 1.928080e-06 1.504837e-05 X 304750 305197 448 - 3.034 3.125 0.303
ENSG00000178605 E010 1270.3178991 9.432786e-05 7.437366e-07 6.352510e-06 X 307360 307506 147 - 2.926 2.990 0.213
ENSG00000178605 E011 504.2262712 1.649376e-04 4.985558e-02 1.089111e-01 X 307507 307512 6 - 2.544 2.584 0.133
ENSG00000178605 E012 1090.3449336 5.324338e-04 8.826939e-03 2.584881e-02 X 307732 307880 149 - 2.876 2.922 0.154
ENSG00000178605 E013 1307.8598798 2.540247e-04 8.444252e-01 9.031714e-01 X 311419 311627 209 - 2.991 2.994 0.010
ENSG00000178605 E014 99.3978744 9.967596e-03 1.003595e-22 8.665819e-21 X 311628 312463 836 - 2.296 1.703 -1.991
ENSG00000178605 E015 31.2499871 7.137968e-03 5.915687e-16 2.303616e-14 X 312532 312717 186 - 1.803 1.202 -2.067
ENSG00000178605 E016 32.2286612 8.700204e-04 2.627259e-06 1.992455e-05 X 312718 312765 48 - 1.645 1.324 -1.105
ENSG00000178605 E017 999.1344638 1.686367e-03 4.869487e-02 1.068449e-01 X 312766 312924 159 - 2.838 2.887 0.164
ENSG00000178605 E018 763.4310805 9.336286e-05 4.385256e-01 5.804045e-01 X 314150 314217 68 - 2.749 2.761 0.038
ENSG00000178605 E019 995.8544484 9.828397e-05 4.714433e-01 6.105530e-01 X 314890 315016 127 - 2.883 2.872 -0.038
ENSG00000178605 E020 454.4911938 1.000723e-03 6.756948e-02 1.393136e-01 X 315017 315020 4 - 2.574 2.528 -0.154
ENSG00000178605 E021 786.0175978 3.261600e-04 1.619130e-02 4.314620e-02 X 315229 315299 71 - 2.807 2.764 -0.140
ENSG00000178605 E022 5.9218928 1.155334e-01 9.847003e-04 3.906857e-03 X 316742 316779 38 - 1.179 0.540 -2.518
ENSG00000178605 E023 21.2148410 4.788368e-02 9.492597e-03 2.751865e-02 X 316780 316913 134 - 1.467 1.151 -1.108
ENSG00000178605 E024 929.2718311 9.026787e-04 1.938250e-02 5.016471e-02 X 316914 317051 138 - 2.882 2.838 -0.146
ENSG00000178605 E025 0.5911862 1.831524e-02 7.460106e-04 3.064319e-03 X 317636 317667 32 - 0.554 0.000 -13.356
ENSG00000178605 E026 656.2653305 2.888630e-03 3.867557e-03 1.277032e-02 X 318439 319111 673 - 2.763 2.680 -0.277