ENSG00000178498

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337737 ENSG00000178498 HEK293_OSMI2_2hA HEK293_TMG_2hB DTX3 protein_coding protein_coding 8.825966 14.86864 4.890135 0.8549714 0.3139324 -1.602349 4.4939761 8.947616 2.5951844 0.85975806 0.3299031 -1.7817294 0.47486667 0.5992333 0.5286 -0.07063333 5.994295e-01 5.771575e-14 FALSE TRUE
ENST00000548804 ENSG00000178498 HEK293_OSMI2_2hA HEK293_TMG_2hB DTX3 protein_coding protein_coding 8.825966 14.86864 4.890135 0.8549714 0.3139324 -1.602349 0.6027567 1.137251 0.3839216 0.27711335 0.1371198 -1.5422010 0.06113333 0.0786000 0.0812 0.00260000 1.000000e+00 5.771575e-14 FALSE TRUE
ENST00000550300 ENSG00000178498 HEK293_OSMI2_2hA HEK293_TMG_2hB DTX3 protein_coding protein_coding 8.825966 14.86864 4.890135 0.8549714 0.3139324 -1.602349 1.6570716 1.490850 0.9486613 0.32057620 0.2269637 -0.6466862 0.20927083 0.0993000 0.1925 0.09320000 2.025034e-01 5.771575e-14 FALSE TRUE
ENST00000551632 ENSG00000178498 HEK293_OSMI2_2hA HEK293_TMG_2hB DTX3 protein_coding protein_coding 8.825966 14.86864 4.890135 0.8549714 0.3139324 -1.602349 0.5043304 1.570497 0.0000000 0.08152769 0.0000000 -7.3042345 0.04876667 0.1057667 0.0000 -0.10576667 5.771575e-14 5.771575e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178498 E001 1.247014 0.0105230014 0.7354945282 0.826255400 12 57604622 57604622 1 + 0.342 0.275 -0.442
ENSG00000178498 E002 1.985359 0.0076547420 0.8678217125 0.918983901 12 57604623 57604638 16 + 0.447 0.413 -0.182
ENSG00000178498 E003 5.435982 0.0034853156 0.8830916641 0.929186576 12 57604639 57604680 42 + 0.716 0.733 0.071
ENSG00000178498 E004 11.847652 0.0025447454 0.3142677862 0.456979286 12 57604681 57604823 143 + 1.114 1.000 -0.416
ENSG00000178498 E005 5.793594 0.0028888757 0.0099358002 0.028601716 12 57604824 57604833 10 + 1.000 0.656 -1.350
ENSG00000178498 E006 25.783976 0.0007901934 0.1963134314 0.321604526 12 57604834 57604858 25 + 1.408 1.303 -0.367
ENSG00000178498 E007 1.245883 0.0201191091 0.3644347098 0.508803420 12 57604859 57605006 148 + 0.447 0.274 -1.032
ENSG00000178498 E008 6.874242 0.0024306040 0.1075294857 0.201892335 12 57605007 57605343 337 + 0.973 0.761 -0.818
ENSG00000178498 E009 13.578796 0.0208037695 0.0200516518 0.051594889 12 57605344 57605570 227 + 1.265 0.990 -0.986
ENSG00000178498 E010 53.218655 0.0094117270 0.0627329782 0.131254742 12 57605571 57605731 161 + 1.731 1.600 -0.443
ENSG00000178498 E011 2.915064 0.0054262502 0.0136291971 0.037376024 12 57605732 57605988 257 + 0.806 0.413 -1.766
ENSG00000178498 E012 5.961316 0.0648263398 0.5644215313 0.691714316 12 57605989 57606029 41 + 0.845 0.752 -0.369
ENSG00000178498 E013 3.673106 0.0993660687 0.0107434240 0.030553779 12 57606030 57606189 160 + 0.944 0.461 -2.041
ENSG00000178498 E014 57.189886 0.0059978092 0.6957168574 0.796249508 12 57606190 57606252 63 + 1.685 1.655 -0.103
ENSG00000178498 E015 64.621245 0.0004924206 0.9076591753 0.945381058 12 57606443 57606518 76 + 1.716 1.716 0.001
ENSG00000178498 E016 4.914257 0.0037663955 0.0001562366 0.000774872 12 57606519 57606864 346 + 1.049 0.540 -2.047
ENSG00000178498 E017 36.276448 0.0011515374 0.6179842610 0.735720884 12 57606865 57606883 19 + 1.508 1.468 -0.135
ENSG00000178498 E018 145.263981 0.0002779673 0.0028132769 0.009713322 12 57606884 57607499 616 + 1.981 2.080 0.330
ENSG00000178498 E019 66.778915 0.0007082966 0.4617616585 0.601682507 12 57607500 57607613 114 + 1.701 1.734 0.112
ENSG00000178498 E020 120.325895 0.0007609399 0.2614468801 0.399090527 12 57608520 57608737 218 + 1.953 1.991 0.128
ENSG00000178498 E021 14.055165 0.0033444937 0.0011165502 0.004358687 12 57608738 57609076 339 + 1.318 1.000 -1.137
ENSG00000178498 E022 238.937735 0.0003163171 0.0012082295 0.004668573 12 57609077 57609804 728 + 2.215 2.293 0.259