ENSG00000178445

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321612 ENSG00000178445 HEK293_OSMI2_2hA HEK293_TMG_2hB GLDC protein_coding protein_coding 19.20623 21.20924 15.8151 1.913175 0.4565994 -0.4231587 12.117578 8.596928 13.9967426 1.7694586 0.4305963 0.7025512 0.65030417 0.4061667 0.8855333 0.4793667 4.973093e-07 1.097408e-13 FALSE TRUE
ENST00000638694 ENSG00000178445 HEK293_OSMI2_2hA HEK293_TMG_2hB GLDC protein_coding processed_transcript 19.20623 21.20924 15.8151 1.913175 0.4565994 -0.4231587 1.824689 3.038097 0.7048581 0.1896997 0.3651070 -2.0921800 0.09055417 0.1450000 0.0450000 -0.1000000 3.854846e-01 1.097408e-13 FALSE TRUE
ENST00000639364 ENSG00000178445 HEK293_OSMI2_2hA HEK293_TMG_2hB GLDC protein_coding processed_transcript 19.20623 21.20924 15.8151 1.913175 0.4565994 -0.4231587 2.434011 2.979963 0.0000000 0.7556611 0.0000000 -8.2239836 0.12099167 0.1399667 0.0000000 -0.1399667 1.097408e-13 1.097408e-13 FALSE TRUE
ENST00000640505 ENSG00000178445 HEK293_OSMI2_2hA HEK293_TMG_2hB GLDC protein_coding processed_transcript 19.20623 21.20924 15.8151 1.913175 0.4565994 -0.4231587 1.134682 4.176844 0.0000000 1.2950067 0.0000000 -8.7097193 0.05187500 0.1952667 0.0000000 -0.1952667 1.046443e-11 1.097408e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178445 E001 0.8751107 0.2569072963 7.495915e-02 1.514686e-01 9 6532467 6532468 2 - 0.000 0.394 12.803
ENSG00000178445 E002 4.9481516 0.0641052335 3.445513e-03 1.156852e-02 9 6532469 6532481 13 - 0.386 0.921 2.359
ENSG00000178445 E003 5.4296646 0.0194176958 1.247915e-03 4.803499e-03 9 6532482 6532502 21 - 0.446 0.952 2.152
ENSG00000178445 E004 7.4881761 0.0062328112 3.327605e-04 1.511364e-03 9 6532503 6532506 4 - 0.587 1.066 1.892
ENSG00000178445 E005 7.4881761 0.0062328112 3.327605e-04 1.511364e-03 9 6532507 6532508 2 - 0.587 1.066 1.892
ENSG00000178445 E006 32.1044374 0.0343845190 1.548151e-03 5.791832e-03 9 6532509 6532556 48 - 1.276 1.627 1.211
ENSG00000178445 E007 76.6106046 0.0063669681 3.623792e-08 4.015186e-07 9 6532557 6532652 96 - 1.667 1.993 1.098
ENSG00000178445 E008 210.9526372 0.0017681930 2.225924e-15 8.036871e-14 9 6532653 6532898 246 - 2.151 2.411 0.868
ENSG00000178445 E009 81.1583070 0.0003608478 8.001150e-06 5.433927e-05 9 6532899 6532920 22 - 1.792 1.980 0.635
ENSG00000178445 E010 218.0662379 0.0025317858 2.490792e-05 1.511251e-04 9 6532921 6533160 240 - 2.244 2.392 0.495
ENSG00000178445 E011 2.5983287 0.0274288777 5.795500e-01 7.044444e-01 9 6534067 6534179 113 - 0.498 0.597 0.458
ENSG00000178445 E012 132.8027053 0.0034806849 6.763018e-04 2.812356e-03 9 6534708 6534788 81 - 2.029 2.180 0.505
ENSG00000178445 E013 2.2633982 0.0529618959 5.640542e-01 6.914341e-01 9 6535947 6536063 117 - 0.446 0.561 0.557
ENSG00000178445 E014 190.5550156 0.0010997098 3.251014e-04 1.481371e-03 9 6536064 6536236 173 - 2.210 2.324 0.380
ENSG00000178445 E015 132.4846905 0.0002825324 7.846210e-02 1.570162e-01 9 6540051 6540146 96 - 2.084 2.146 0.207
ENSG00000178445 E016 1.1027863 0.0305055214 4.001507e-01 5.438625e-01 9 6540147 6541816 1670 - 0.235 0.393 1.039
ENSG00000178445 E017 139.3618764 0.0002980314 4.730314e-01 6.120489e-01 9 6550803 6550914 112 - 2.126 2.154 0.095
ENSG00000178445 E018 126.8107812 0.0044619193 6.433712e-01 7.559480e-01 9 6553368 6553509 142 - 2.111 2.091 -0.069
ENSG00000178445 E019 112.6799161 0.0022529235 7.339209e-01 8.250364e-01 9 6554669 6554781 113 - 2.055 2.045 -0.034
ENSG00000178445 E020 0.5159433 0.2797688206 5.701103e-01 6.966131e-01 9 6554782 6554929 148 - 0.234 0.114 -1.248
ENSG00000178445 E021 148.3354632 0.0002813158 9.689382e-01 9.845673e-01 9 6556153 6556302 150 - 2.169 2.175 0.021
ENSG00000178445 E022 11.2231435 0.0015706534 2.876548e-03 9.901402e-03 9 6557666 6557919 254 - 0.872 1.190 1.168
ENSG00000178445 E023 16.3805938 0.0018600093 2.155049e-06 1.664089e-05 9 6557920 6558093 174 - 0.912 1.365 1.631
ENSG00000178445 E024 18.9378584 0.0009968442 1.473483e-08 1.760846e-07 9 6558094 6558471 378 - 0.930 1.441 1.823
ENSG00000178445 E025 5.9826230 0.0481898192 2.554846e-01 3.923794e-01 9 6558472 6558558 87 - 0.724 0.917 0.756
ENSG00000178445 E026 146.8773425 0.0002709577 7.644592e-01 8.475316e-01 9 6558559 6558684 126 - 2.158 2.174 0.054
ENSG00000178445 E027 131.5323616 0.0023462381 6.950561e-01 7.957474e-01 9 6565354 6565429 76 - 2.124 2.115 -0.031
ENSG00000178445 E028 0.6642364 0.0649907836 8.532164e-01 9.091278e-01 9 6565430 6565861 432 - 0.235 0.202 -0.275
ENSG00000178445 E029 0.7029582 0.0172671820 4.181601e-01 5.614440e-01 9 6566429 6566517 89 - 0.133 0.276 1.309
ENSG00000178445 E030 0.4751703 0.0204738098 6.948651e-01 7.955912e-01 9 6567178 6567462 285 - 0.133 0.202 0.723
ENSG00000178445 E031 0.0000000       9 6585039 6585075 37 -      
ENSG00000178445 E032 169.2647374 0.0004205835 2.665114e-02 6.526770e-02 9 6587141 6587283 143 - 2.260 2.205 -0.184
ENSG00000178445 E033 90.4641891 0.0003413066 9.672901e-03 2.795707e-02 9 6588401 6588442 42 - 2.009 1.920 -0.298
ENSG00000178445 E034 115.2514217 0.0002843346 8.881901e-03 2.598446e-02 9 6588618 6588702 85 - 2.106 2.027 -0.265
ENSG00000178445 E035 67.8699232 0.0038551312 1.657079e-01 2.826174e-01 9 6589195 6589206 12 - 1.872 1.805 -0.226
ENSG00000178445 E036 102.0457969 0.0002915105 5.347601e-01 6.667634e-01 9 6589207 6589292 86 - 2.018 2.003 -0.050
ENSG00000178445 E037 0.0000000       9 6591848 6592142 295 -      
ENSG00000178445 E038 82.3309378 0.0025190756 8.689115e-01 9.197524e-01 9 6592143 6592223 81 - 1.919 1.916 -0.011
ENSG00000178445 E039 113.7755350 0.0039389345 2.111919e-01 3.399177e-01 9 6592851 6592990 140 - 2.085 2.031 -0.183
ENSG00000178445 E040 0.1515154 0.0451661440 4.102860e-01   9 6592991 6593094 104 - 0.133 0.000 -11.369
ENSG00000178445 E041 48.7968671 0.0005089423 3.376203e-02 7.927562e-02 9 6595014 6595027 14 - 1.752 1.654 -0.334
ENSG00000178445 E042 82.3229837 0.0026721834 1.999198e-01 3.261475e-01 9 6595028 6595119 92 - 1.948 1.895 -0.178
ENSG00000178445 E043 97.0369619 0.0003845031 8.946811e-02 1.743229e-01 9 6602109 6602205 97 - 2.021 1.967 -0.181
ENSG00000178445 E044 136.8188580 0.0009078620 5.976920e-04 2.525278e-03 9 6604588 6604784 197 - 2.196 2.092 -0.348
ENSG00000178445 E045 0.5085815 0.2383760120 7.389380e-01 8.286987e-01 9 6604785 6604797 13 - 0.133 0.203 0.733
ENSG00000178445 E046 115.8257863 0.0002814351 3.214236e-05 1.897916e-04 9 6605131 6605275 145 - 2.138 2.010 -0.429
ENSG00000178445 E047 51.0138753 0.0004807366 9.190569e-04 3.681260e-03 9 6605276 6605278 3 - 1.799 1.645 -0.522
ENSG00000178445 E048 0.1817044 0.0404253574 5.770927e-01   9 6605279 6605370 92 - 0.000 0.113 10.542
ENSG00000178445 E049 0.0000000       9 6605869 6606149 281 -      
ENSG00000178445 E050 94.0981283 0.0003228339 3.420038e-05 2.005311e-04 9 6606592 6606669 78 - 2.055 1.912 -0.479
ENSG00000178445 E051 73.2106861 0.0047246549 2.616052e-01 3.992582e-01 9 6610192 6610255 64 - 1.898 1.845 -0.177
ENSG00000178445 E052 89.5339960 0.0003159922 1.839256e-03 6.724206e-03 9 6610256 6610356 101 - 2.013 1.904 -0.366
ENSG00000178445 E053 91.8875220 0.0003122401 3.113667e-06 2.320698e-05 9 6620184 6620319 136 - 2.052 1.888 -0.551
ENSG00000178445 E054 0.0000000       9 6622785 6622918 134 -      
ENSG00000178445 E055 0.0000000       9 6622919 6623082 164 -      
ENSG00000178445 E056 0.0000000       9 6644531 6644613 83 -      
ENSG00000178445 E057 78.2217597 0.0003319374 6.075233e-11 1.109442e-09 9 6644614 6644692 79 - 2.026 1.775 -0.847
ENSG00000178445 E058 0.1817044 0.0404253574 5.770927e-01   9 6644693 6644830 138 - 0.000 0.113 10.542
ENSG00000178445 E059 120.6115982 0.0070675823 1.001874e-08 1.235127e-07 9 6645245 6645729 485 - 2.227 1.937 -0.972