ENSG00000178252

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000415265 ENSG00000178252 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR6 protein_coding protein_coding 153.0774 242.5535 99.06358 9.217424 0.76947 -1.29179 7.756406 28.02438 0.5150533 4.607474 0.2771096 -5.7385894 0.03440417 0.11496667 0.005166667 -0.10980000 8.760284e-03 4.3408e-07 FALSE TRUE
ENST00000452875 ENSG00000178252 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR6 protein_coding nonsense_mediated_decay 153.0774 242.5535 99.06358 9.217424 0.76947 -1.29179 11.706419 12.19312 8.8200488 1.577366 0.8833601 -0.4667570 0.08244167 0.05066667 0.089033333 0.03836667 5.706245e-02 4.3408e-07 FALSE TRUE
ENST00000471162 ENSG00000178252 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR6 protein_coding retained_intron 153.0774 242.5535 99.06358 9.217424 0.76947 -1.29179 20.050570 18.44695 16.0528025 2.461113 1.3809260 -0.2004409 0.14474583 0.07550000 0.162266667 0.08676667 1.758462e-04 4.3408e-07 TRUE TRUE
ENST00000492780 ENSG00000178252 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR6 protein_coding retained_intron 153.0774 242.5535 99.06358 9.217424 0.76947 -1.29179 24.492666 51.72037 5.4927341 10.174217 0.4452669 -3.2327911 0.13152083 0.21230000 0.055466667 -0.15683333 2.673853e-05 4.3408e-07 FALSE TRUE
ENST00000608424 ENSG00000178252 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR6 protein_coding protein_coding 153.0774 242.5535 99.06358 9.217424 0.76947 -1.29179 61.999784 103.48236 40.4799271 7.401524 2.4146542 -1.3538893 0.40387917 0.42786667 0.408433333 -0.01943333 8.994118e-01 4.3408e-07 FALSE TRUE
ENST00000610967 ENSG00000178252 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR6 protein_coding protein_coding 153.0774 242.5535 99.06358 9.217424 0.76947 -1.29179 15.459863 17.64292 15.2903166 3.011290 1.6024908 -0.2063452 0.11571667 0.07300000 0.154433333 0.08143333 2.254822e-02 4.3408e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.