ENSG00000178209

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356346 ENSG00000178209 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEC protein_coding protein_coding 10.1177 11.74662 8.255257 1.302347 0.3241504 -0.5083415 4.8224661 4.8817345 4.0537520 1.01188838 0.1052027 -0.2675337 0.4745250 0.407966667 0.4919667 0.0840000 5.141826e-01 2.039355e-08 FALSE TRUE
ENST00000527096 ENSG00000178209 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEC protein_coding protein_coding 10.1177 11.74662 8.255257 1.302347 0.3241504 -0.5083415 0.4986025 0.1057567 0.9277474 0.06643063 0.1272052 3.0181042 0.0577250 0.008766667 0.1115000 0.1027333 2.039355e-08 2.039355e-08 FALSE TRUE
ENST00000527303 ENSG00000178209 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEC protein_coding protein_coding 10.1177 11.74662 8.255257 1.302347 0.3241504 -0.5083415 4.4868680 6.6443571 3.1057857 0.69162332 0.1493716 -1.0947033 0.4367042 0.574466667 0.3760667 -0.1984000 5.581775e-02 2.039355e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178209 E001 615.9303705 0.0251483460 2.038687e-10 3.411262e-09 8 143915153 143916176 1024 - 2.377 2.950 1.910
ENSG00000178209 E002 970.4042921 0.0037664234 6.104117e-16 2.372116e-14 8 143916177 143918083 1907 - 2.767 3.094 1.088
ENSG00000178209 E003 137.2140217 0.0004684358 6.674144e-09 8.501859e-08 8 143918084 143918342 259 - 1.937 2.228 0.977
ENSG00000178209 E004 87.1177492 0.0066837720 2.575462e-03 8.990654e-03 8 143918343 143918438 96 - 1.757 2.032 0.925
ENSG00000178209 E005 143.9932639 0.0002562176 3.713497e-05 2.157153e-04 8 143918439 143918666 228 - 2.009 2.235 0.755
ENSG00000178209 E006 1001.3032780 0.0011591248 6.357066e-01 7.499129e-01 8 143918667 143922107 3441 - 2.925 3.039 0.378
ENSG00000178209 E007 19.9946914 0.0015568637 8.669605e-01 9.183902e-01 8 143922108 143922109 2 - 1.272 1.352 0.278
ENSG00000178209 E008 87.0193917 0.0038743354 7.614791e-01 8.453407e-01 8 143922110 143922395 286 - 1.884 1.971 0.291
ENSG00000178209 E009 441.6381324 0.0081460247 3.719860e-03 1.235456e-02 8 143922504 143925884 3381 - 2.647 2.635 -0.042
ENSG00000178209 E010 57.4253425 0.0125925467 7.015050e-04 2.904544e-03 8 143926784 143926882 99 - 1.826 1.695 -0.443
ENSG00000178209 E011 54.3973642 0.0075834453 2.781307e-05 1.666857e-04 8 143926977 143927081 105 - 1.818 1.654 -0.552
ENSG00000178209 E012 45.9285806 0.0017976999 3.502112e-09 4.693771e-08 8 143927252 143927335 84 - 1.775 1.548 -0.771
ENSG00000178209 E013 75.7593539 0.0196732593 1.365606e-04 6.882599e-04 8 143927410 143927766 357 - 1.969 1.787 -0.615
ENSG00000178209 E014 53.1435326 0.0160042497 1.773270e-02 4.655819e-02 8 143927854 143927992 139 - 1.762 1.688 -0.250
ENSG00000178209 E015 57.4241274 0.0079423351 2.753497e-02 6.708182e-02 8 143929103 143929281 179 - 1.775 1.739 -0.122
ENSG00000178209 E016 46.8941850 0.0017226100 7.623565e-03 2.283345e-02 8 143929414 143929571 158 - 1.693 1.644 -0.166
ENSG00000178209 E017 45.1823861 0.0060292087 3.330482e-06 2.469374e-05 8 143929646 143929829 184 - 1.757 1.557 -0.678
ENSG00000178209 E018 33.7832904 0.0007239077 6.833085e-05 3.720811e-04 8 143929936 143930062 127 - 1.611 1.467 -0.492
ENSG00000178209 E019 30.0900387 0.0006820888 1.265913e-04 6.438214e-04 8 143930144 143930298 155 - 1.565 1.418 -0.504
ENSG00000178209 E020 32.4172457 0.0006619014 7.058781e-07 6.056677e-06 8 143930384 143930536 153 - 1.625 1.418 -0.709
ENSG00000178209 E021 33.5632443 0.0237508861 6.030425e-03 1.869124e-02 8 143931534 143931659 126 - 1.618 1.462 -0.534
ENSG00000178209 E022 31.6054549 0.0277770564 1.081825e-02 3.072874e-02 8 143931937 143932032 96 - 1.585 1.441 -0.495
ENSG00000178209 E023 42.8665028 0.0266001717 1.713512e-03 6.324170e-03 8 143932130 143932234 105 - 1.733 1.547 -0.634
ENSG00000178209 E024 52.0035927 0.0333708224 5.674723e-03 1.775226e-02 8 143932400 143932561 162 - 1.805 1.641 -0.556
ENSG00000178209 E025 31.8661211 0.0083402765 3.049242e-03 1.041071e-02 8 143932635 143932712 78 - 1.577 1.454 -0.420
ENSG00000178209 E026 70.3187175 0.0038842929 9.435603e-12 1.975190e-10 8 143932793 143933111 319 - 1.968 1.719 -0.839
ENSG00000178209 E027 41.1906615 0.0073616693 2.235688e-08 2.582497e-07 8 143933197 143933351 155 - 1.755 1.474 -0.956
ENSG00000178209 E028 29.4977428 0.0007031568 4.058877e-04 1.797391e-03 8 143933998 143934091 94 - 1.545 1.413 -0.451
ENSG00000178209 E029 39.5464631 0.0131751560 1.244790e-04 6.343046e-04 8 143934318 143934445 128 - 1.699 1.504 -0.667
ENSG00000178209 E030 34.0749923 0.0214737545 4.038170e-05 2.324863e-04 8 143934635 143934730 96 - 1.672 1.394 -0.952
ENSG00000178209 E031 42.9928839 0.0205367332 2.954567e-06 2.213699e-05 8 143934810 143934929 120 - 1.780 1.483 -1.010
ENSG00000178209 E032 16.7812238 0.0012294581 2.557251e-03 8.933827e-03 8 143935011 143935022 12 - 1.324 1.167 -0.552
ENSG00000178209 E033 43.4770536 0.0013599392 3.282264e-08 3.667876e-07 8 143935023 143935117 95 - 1.744 1.536 -0.708
ENSG00000178209 E034 51.1794045 0.0004650666 5.423802e-19 3.083802e-17 8 143935198 143935313 116 - 1.870 1.523 -1.176
ENSG00000178209 E035 49.7025825 0.0004778648 2.186902e-15 7.905020e-14 8 143935848 143936014 167 - 1.841 1.539 -1.025
ENSG00000178209 E036 41.5607895 0.0005487514 2.179105e-13 5.904245e-12 8 143936979 143937071 93 - 1.765 1.458 -1.045
ENSG00000178209 E037 39.7154440 0.0062642364 1.048738e-10 1.844414e-09 8 143937165 143937242 78 - 1.757 1.422 -1.145
ENSG00000178209 E038 0.6060617 0.8707347057 2.360671e-01 3.696222e-01 8 143937664 143937748 85 - 0.376 0.000 -10.688
ENSG00000178209 E039 0.2987644 0.0268580406 1.283992e-01   8 143937749 143937784 36 - 0.226 0.000 -13.454
ENSG00000178209 E040 41.4856957 0.0007623774 1.104966e-17 5.396558e-16 8 143938151 143938240 90 - 1.794 1.413 -1.299
ENSG00000178209 E041 0.0000000       8 143938401 143938415 15 -      
ENSG00000178209 E042 32.6766538 0.0007478982 3.562156e-12 7.982491e-11 8 143938631 143938692 62 - 1.678 1.346 -1.140
ENSG00000178209 E043 0.0000000       8 143939350 143939597 248 -      
ENSG00000178209 E044 0.0000000       8 143942392 143942524 133 -      
ENSG00000178209 E045 0.2987644 0.0268580406 1.283992e-01   8 143943779 143943958 180 - 0.226 0.000 -13.454
ENSG00000178209 E046 0.0000000       8 143944648 143944737 90 -      
ENSG00000178209 E047 0.0000000       8 143946350 143946384 35 -      
ENSG00000178209 E048 0.0000000       8 143946385 143946547 163 -      
ENSG00000178209 E049 1.9886861 0.0068921715 1.192844e-02 3.336217e-02 8 143950184 143950876 693 - 0.644 0.286 -1.867
ENSG00000178209 E050 0.4031496 0.0238272847 2.978424e-01 4.392171e-01 8 143953726 143953920 195 - 0.000 0.210 13.046
ENSG00000178209 E051 0.0000000       8 143958595 143958799 205 -      
ENSG00000178209 E052 16.5266767 0.0111131331 4.369972e-06 3.151660e-05 8 143973403 143973538 136 - 1.401 1.053 -1.230
ENSG00000178209 E053 19.6532856 0.0009221628 1.992488e-09 2.790293e-08 8 143975177 143975375 199 - 1.481 1.108 -1.308
ENSG00000178209 E054 6.5219942 0.0278098457 1.582435e-04 7.838813e-04 8 143976703 143976991 289 - 1.076 0.614 -1.811