ENSG00000178188

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359285 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding protein_coding 33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 3.737795 6.044153 1.3030864 1.8988141 0.67827855 -2.2049634 0.10167083 0.12960000 0.06283333 -0.06676667 6.762421e-01 2.316472e-10 FALSE TRUE
ENST00000395532 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding protein_coding 33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 2.255436 3.824634 0.5795941 1.9250497 0.29198676 -2.7012952 0.06143333 0.08190000 0.02556667 -0.05633333 8.559768e-01 2.316472e-10 FALSE TRUE
ENST00000563674 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding processed_transcript 33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 2.488080 2.706534 1.6051226 0.4699926 0.09730351 -0.7501235 0.07483750 0.05806667 0.07466667 0.01660000 5.044274e-01 2.316472e-10   TRUE
ENST00000568868 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding protein_coding 33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 4.402850 2.952559 3.9478171 1.0000708 0.63123903 0.4178610 0.13395000 0.06213333 0.18253333 0.12040000 3.891663e-02 2.316472e-10 FALSE FALSE
ENST00000684370 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding protein_coding 33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 2.269244 1.899376 1.6790635 0.4049846 0.11220866 -0.1768776 0.07271250 0.04043333 0.07916667 0.03873333 7.967540e-02 2.316472e-10 FALSE TRUE
MSTRG.12369.19 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding   33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 1.274520 2.951446 0.0000000 0.8094929 0.00000000 -8.2101578 0.02851250 0.06353333 0.00000000 -0.06353333 2.316472e-10 2.316472e-10 FALSE TRUE
MSTRG.12369.2 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding   33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 1.395045 2.377626 0.0000000 0.5372229 0.00000000 -7.8994328 0.03734167 0.05230000 0.00000000 -0.05230000 2.398115e-10 2.316472e-10 FALSE TRUE
MSTRG.12369.22 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding   33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 2.696592 4.223883 1.7205425 1.6847267 0.20130830 -1.2907569 0.07967083 0.09016667 0.08010000 -0.01006667 9.939855e-01 2.316472e-10 FALSE TRUE
MSTRG.12369.23 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding   33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 3.837319 4.235992 3.5409692 0.4705787 0.33634578 -0.2578887 0.12083333 0.09103333 0.16390000 0.07286667 6.485334e-05 2.316472e-10 FALSE TRUE
MSTRG.12369.25 ENSG00000178188 HEK293_OSMI2_2hA HEK293_TMG_2hB SH2B1 protein_coding   33.99342 46.2633 21.50937 2.475308 1.175081 -1.104544 2.950952 4.486299 1.6022773 1.4642581 0.57948039 -1.4796381 0.08908333 0.09823333 0.07510000 -0.02313333 8.694724e-01 2.316472e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178188 E001 0.0000000       16 28846543 28846563 21 +      
ENSG00000178188 E002 0.0000000       16 28846564 28846599 36 +      
ENSG00000178188 E003 0.0000000       16 28846600 28846604 5 +      
ENSG00000178188 E004 1.4244651 0.5200618434 9.592750e-01 9.784579e-01 16 28846605 28846642 38 + 0.311 0.353 0.259
ENSG00000178188 E005 3.7753097 0.1093594002 6.502925e-01 7.613659e-01 16 28846643 28846685 43 + 0.558 0.648 0.397
ENSG00000178188 E006 4.2838912 0.1304980839 7.632377e-01 8.466168e-01 16 28846686 28846688 3 + 0.617 0.686 0.298
ENSG00000178188 E007 9.2457222 0.1307080384 5.964022e-01 7.183605e-01 16 28846689 28846827 139 + 0.891 0.969 0.291
ENSG00000178188 E008 0.0000000       16 28851514 28851625 112 +      
ENSG00000178188 E009 3.0131170 0.0051915108 3.308802e-01 4.744530e-01 16 28861618 28861620 3 + 0.410 0.584 0.851
ENSG00000178188 E010 5.9541261 0.0031349858 7.200709e-02 1.466752e-01 16 28861621 28861747 127 + 0.558 0.837 1.164
ENSG00000178188 E011 4.9507986 0.0172246808 5.300398e-01 6.627293e-01 16 28862804 28863029 226 + 0.795 0.702 -0.378
ENSG00000178188 E012 3.9395876 0.0043119521 1.511455e-01 2.632290e-01 16 28863030 28863166 137 + 0.795 0.583 -0.887
ENSG00000178188 E013 5.3664977 0.0967103086 5.950088e-02 1.257658e-01 16 28863167 28863289 123 + 0.972 0.657 -1.243
ENSG00000178188 E014 2.7751016 0.1764169771 3.369872e-01 4.808479e-01 16 28863290 28863306 17 + 0.669 0.494 -0.789
ENSG00000178188 E015 3.4277985 0.1511764113 1.740966e-01 2.934949e-01 16 28863307 28863345 39 + 0.794 0.524 -1.156
ENSG00000178188 E016 19.3908539 0.0044615644 1.207847e-02 3.372384e-02 16 28863346 28863558 213 + 1.390 1.176 -0.753
ENSG00000178188 E017 27.2114727 0.0007545879 1.913627e-03 6.957831e-03 16 28863559 28863667 109 + 1.531 1.315 -0.749
ENSG00000178188 E018 34.6584605 0.0005911096 5.090653e-02 1.107790e-01 16 28863668 28863754 87 + 1.576 1.452 -0.425
ENSG00000178188 E019 0.9619687 0.0122336696 2.560360e-01 3.929970e-01 16 28863755 28863756 2 + 0.410 0.206 -1.373
ENSG00000178188 E020 1.2554346 0.0131386377 1.909560e-01 3.149467e-01 16 28863757 28863804 48 + 0.491 0.257 -1.374
ENSG00000178188 E021 0.7405235 0.0160197839 1.375333e-01 2.446543e-01 16 28863805 28863805 1 + 0.410 0.147 -1.960
ENSG00000178188 E022 2.0733896 0.0076890142 5.223678e-02 1.131358e-01 16 28863806 28863842 37 + 0.669 0.345 -1.596
ENSG00000178188 E023 7.0333584 0.0026420893 3.845461e-01 5.286843e-01 16 28863843 28863877 35 + 0.921 0.811 -0.424
ENSG00000178188 E024 15.4587538 0.0476550688 5.552211e-01 6.841032e-01 16 28863878 28863945 68 + 1.210 1.133 -0.273
ENSG00000178188 E025 3.1784532 0.0051854487 7.530774e-02 1.520148e-01 16 28863946 28863974 29 + 0.757 0.481 -1.220
ENSG00000178188 E026 8.6251942 0.0020184835 2.152159e-01 3.446802e-01 16 28863975 28863997 23 + 1.018 0.874 -0.541
ENSG00000178188 E027 42.9909199 0.0064243800 2.007550e-03 7.249382e-03 16 28863998 28864187 190 + 1.714 1.509 -0.699
ENSG00000178188 E028 36.5561837 0.0192087305 1.616015e-02 4.308047e-02 16 28864188 28864262 75 + 1.658 1.442 -0.737
ENSG00000178188 E029 41.9560289 0.0297661632 1.215613e-02 3.390420e-02 16 28864263 28864338 76 + 1.739 1.487 -0.859
ENSG00000178188 E030 237.1272502 0.0004932812 7.360730e-32 1.398664e-29 16 28864339 28865624 1286 + 2.508 2.212 -0.988
ENSG00000178188 E031 36.7326077 0.0008350297 1.187746e-04 6.082799e-04 16 28865625 28866011 387 + 1.668 1.433 -0.802
ENSG00000178188 E032 418.0363533 0.0028350000 9.848426e-02 1.881904e-01 16 28866012 28866634 623 + 2.586 2.541 -0.150
ENSG00000178188 E033 163.7617939 0.0002601576 5.991264e-02 1.264584e-01 16 28866635 28866677 43 + 2.187 2.130 -0.192
ENSG00000178188 E034 450.9865584 0.0001320878 7.576763e-03 2.271123e-02 16 28866678 28867033 356 + 2.620 2.572 -0.160
ENSG00000178188 E035 2.1661346 0.0525493539 1.991440e-01 3.251507e-01 16 28867154 28867330 177 + 0.617 0.384 -1.145
ENSG00000178188 E036 188.6708878 0.0001933773 8.831950e-01 9.292641e-01 16 28867331 28867373 43 + 2.210 2.207 -0.011
ENSG00000178188 E037 240.1053278 0.0001901509 2.709027e-01 4.095628e-01 16 28867374 28867432 59 + 2.332 2.304 -0.091
ENSG00000178188 E038 241.1507910 0.0001980637 2.704635e-01 4.091291e-01 16 28869006 28869093 88 + 2.292 2.322 0.100
ENSG00000178188 E039 120.7214089 0.0002615970 1.763290e-02 4.634498e-02 16 28869094 28869097 4 + 1.944 2.035 0.306
ENSG00000178188 E040 183.1378577 0.0001981827 2.125272e-02 5.411921e-02 16 28869208 28869276 69 + 2.139 2.210 0.239
ENSG00000178188 E041 229.6094832 0.0002091962 1.170771e-03 4.541526e-03 16 28869277 28869383 107 + 2.223 2.313 0.303
ENSG00000178188 E042 251.7562167 0.0001970209 1.682342e-07 1.636281e-06 16 28871780 28871983 204 + 2.221 2.363 0.474
ENSG00000178188 E043 8.8104281 0.0609578428 1.134988e-01 2.106264e-01 16 28871984 28872189 206 + 1.117 0.849 -0.994
ENSG00000178188 E044 115.7438282 0.0002845740 1.583585e-01 2.729398e-01 16 28872190 28872206 17 + 1.954 2.009 0.185
ENSG00000178188 E045 175.3535254 0.0002261292 5.973392e-02 1.261711e-01 16 28872207 28872252 46 + 2.129 2.189 0.200
ENSG00000178188 E046 234.1879855 0.0001875955 1.675880e-01 2.850541e-01 16 28872253 28872339 87 + 2.272 2.310 0.127
ENSG00000178188 E047 224.5212522 0.0001744833 4.851850e-02 1.065418e-01 16 28872340 28872401 62 + 2.240 2.295 0.184
ENSG00000178188 E048 338.1383625 0.0001461656 6.129135e-02 1.288128e-01 16 28872534 28872705 172 + 2.427 2.469 0.142
ENSG00000178188 E049 54.1015540 0.0012829365 5.555020e-02 1.189214e-01 16 28872706 28872758 53 + 1.744 1.641 -0.348
ENSG00000178188 E050 10.5679883 0.0055182806 3.561836e-05 2.078354e-04 16 28872759 28872813 55 + 1.274 0.838 -1.597
ENSG00000178188 E051 25.3353794 0.0007981061 1.765899e-02 4.640198e-02 16 28872928 28873169 242 + 1.474 1.301 -0.598
ENSG00000178188 E052 211.6684198 0.0002434970 1.786767e-05 1.120742e-04 16 28873170 28873269 100 + 2.157 2.284 0.426
ENSG00000178188 E053 636.8453094 0.0022568178 7.354942e-07 6.288914e-06 16 28873447 28874212 766 + 2.631 2.766 0.449