ENSG00000178105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322536 ENSG00000178105 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX10 protein_coding protein_coding 21.68194 16.94116 25.39978 1.630779 0.3637184 0.5840002 18.890590 10.480010 24.77972 0.08965359 0.3720413 1.240726 0.8362958 0.6293667 0.9757 0.3463333 6.610164e-04 5.11082e-29 FALSE TRUE
ENST00000524979 ENSG00000178105 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX10 protein_coding processed_transcript 21.68194 16.94116 25.39978 1.630779 0.3637184 0.5840002 2.356154 6.221724 0.00000 1.54918451 0.0000000 -9.283487 0.1382125 0.3571333 0.0000 -0.3571333 5.110820e-29 5.11082e-29 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178105 E001 0.4396707 0.0271502557 2.266950e-01 3.584506e-01 11 108665058 108665066 9 + 0.231 0.000 -13.023
ENSG00000178105 E002 1.1717632 0.2119266485 4.741627e-02 1.045711e-01 11 108665067 108665068 2 + 0.457 0.000 -14.431
ENSG00000178105 E003 1.1717632 0.2119266485 4.741627e-02 1.045711e-01 11 108665069 108665069 1 + 0.457 0.000 -14.431
ENSG00000178105 E004 1.9467301 0.1666811205 7.242713e-02 1.473787e-01 11 108665070 108665073 4 + 0.580 0.162 -2.629
ENSG00000178105 E005 7.0657756 0.0185797335 6.100260e-03 1.887342e-02 11 108665074 108665081 8 + 1.005 0.621 -1.524
ENSG00000178105 E006 40.4746226 0.0157562058 3.495735e-03 1.171285e-02 11 108665082 108665121 40 + 1.682 1.455 -0.772
ENSG00000178105 E007 103.8442475 0.0188123781 3.534344e-03 1.182465e-02 11 108665122 108665339 218 + 2.074 1.876 -0.665
ENSG00000178105 E008 54.1967918 0.0056781873 2.055899e-02 5.266854e-02 11 108673467 108673527 61 + 1.771 1.649 -0.414
ENSG00000178105 E009 90.5260296 0.0060896654 1.394682e-04 7.012538e-04 11 108675596 108675726 131 + 2.010 1.823 -0.628
ENSG00000178105 E010 0.0000000       11 108675727 108675794 68 +      
ENSG00000178105 E011 143.6726324 0.0002814660 7.459656e-11 1.343355e-09 11 108677085 108677243 159 + 2.210 2.029 -0.606
ENSG00000178105 E012 135.3168106 0.0002630675 7.896369e-09 9.920050e-08 11 108678315 108678435 121 + 2.181 2.021 -0.537
ENSG00000178105 E013 142.3951669 0.0002505092 2.155635e-06 1.664473e-05 11 108679371 108679560 190 + 2.191 2.069 -0.407
ENSG00000178105 E014 0.2955422 0.0289829817 6.639295e-01   11 108685149 108685298 150 + 0.091 0.162 0.947
ENSG00000178105 E015 104.5793781 0.0016538293 1.636605e-03 6.078694e-03 11 108688936 108689062 127 + 2.048 1.944 -0.349
ENSG00000178105 E016 112.3432166 0.0002826013 3.726324e-02 8.597462e-02 11 108691876 108692038 163 + 2.060 2.014 -0.155
ENSG00000178105 E017 89.7698029 0.0003876478 1.147251e-01 2.124298e-01 11 108693516 108693600 85 + 1.959 1.923 -0.119
ENSG00000178105 E018 0.4815130 0.0205753114 2.789611e-01 4.186505e-01 11 108701792 108706738 4947 + 0.091 0.280 1.948
ENSG00000178105 E019 97.3612411 0.0005953647 8.235655e-01 8.888370e-01 11 108706739 108706837 99 + 1.966 2.000 0.114
ENSG00000178105 E020 96.8416052 0.0020331525 4.995272e-01 6.358525e-01 11 108715879 108715966 88 + 1.956 2.009 0.175
ENSG00000178105 E021 0.0000000       11 108717336 108717354 19 +      
ENSG00000178105 E022 0.2965864 0.1116461685 9.889582e-02   11 108717355 108717615 261 + 0.000 0.277 14.042
ENSG00000178105 E023 105.3772407 0.0024955863 3.151854e-01 4.579375e-01 11 108719797 108719885 89 + 1.988 2.054 0.221
ENSG00000178105 E024 350.3804944 0.0032623348 5.897801e-01 7.128089e-01 11 108722997 108723462 466 + 2.517 2.558 0.136
ENSG00000178105 E025 0.4460135 0.0312769103 2.269773e-01 3.587892e-01 11 108731538 108731679 142 + 0.231 0.000 -13.021
ENSG00000178105 E026 0.0000000       11 108733839 108734320 482 +      
ENSG00000178105 E027 0.2987644 0.0273415226 4.222121e-01   11 108746246 108746295 50 + 0.167 0.000 -12.436
ENSG00000178105 E028 0.0000000       11 108749107 108750150 1044 +      
ENSG00000178105 E029 0.0000000       11 108766209 108766351 143 +      
ENSG00000178105 E030 0.0000000       11 108767314 108767404 91 +      
ENSG00000178105 E031 0.3666179 0.0308972487 6.587057e-01 7.677437e-01 11 108767937 108768001 65 + 0.091 0.162 0.953
ENSG00000178105 E032 0.6664265 0.0164063819 5.571319e-01 6.856104e-01 11 108838356 108838445 90 + 0.167 0.280 0.950
ENSG00000178105 E033 161.8170592 0.0038441080 2.232814e-01 3.543106e-01 11 108838446 108838565 120 + 2.169 2.244 0.252
ENSG00000178105 E034 184.8300603 0.0006569639 1.442788e-01 2.538254e-01 11 108841315 108841476 162 + 2.233 2.300 0.225
ENSG00000178105 E035 1.5887416 0.0593843650 5.923485e-01 7.149030e-01 11 108846432 108847934 1503 + 0.337 0.452 0.646
ENSG00000178105 E036 0.9556140 0.2638681958 4.669042e-01 6.064323e-01 11 108848020 108848128 109 + 0.336 0.164 -1.343
ENSG00000178105 E037 1.0435544 0.0269859880 6.953873e-01 7.959972e-01 11 108851691 108852152 462 + 0.337 0.279 -0.377
ENSG00000178105 E038 128.9130705 0.0070299899 5.576464e-02 1.192914e-01 11 108852153 108852209 57 + 2.053 2.178 0.418
ENSG00000178105 E039 0.0000000       11 108853974 108854223 250 +      
ENSG00000178105 E040 0.1817044 0.0415312654 2.696598e-01   11 108860575 108860957 383 + 0.000 0.162 13.061
ENSG00000178105 E041 0.0000000       11 108868248 108868332 85 +      
ENSG00000178105 E042 188.0919685 0.0021403024 4.606148e-04 2.008934e-03 11 108917873 108918018 146 + 2.208 2.350 0.473
ENSG00000178105 E043 0.9503285 0.3136579717 9.604381e-01 9.790748e-01 11 108918019 108922243 4225 + 0.287 0.281 -0.038
ENSG00000178105 E044 1.1040209 0.0116157645 7.015585e-01 8.006853e-01 11 108929519 108929708 190 + 0.337 0.280 -0.372
ENSG00000178105 E045 453.6442369 0.0035459945 1.142872e-11 2.355971e-10 11 108940246 108940999 754 + 2.546 2.773 0.753