ENSG00000178053

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355893 ENSG00000178053 HEK293_OSMI2_2hA HEK293_TMG_2hB MLF1 protein_coding protein_coding 15.36958 6.178075 24.17498 1.152746 1.024068 1.966549 4.3937941 2.1170577 6.609359 0.4022438 0.49964001 1.637832 0.30731667 0.3519333 0.27450000 -0.07743333 5.821489e-01 1.164734e-08 FALSE  
ENST00000359117 ENSG00000178053 HEK293_OSMI2_2hA HEK293_TMG_2hB MLF1 protein_coding protein_coding 15.36958 6.178075 24.17498 1.152746 1.024068 1.966549 1.6177644 0.7175565 2.041001 0.2911678 0.09992214 1.495197 0.09980000 0.1057333 0.08443333 -0.02130000 6.978407e-01 1.164734e-08 FALSE  
ENST00000487838 ENSG00000178053 HEK293_OSMI2_2hA HEK293_TMG_2hB MLF1 protein_coding nonsense_mediated_decay 15.36958 6.178075 24.17498 1.152746 1.024068 1.966549 0.9096469 0.0000000 2.258410 0.0000000 0.35819341 7.825538 0.06524167 0.0000000 0.09453333 0.09453333 1.164734e-08 1.164734e-08 FALSE  
ENST00000495452 ENSG00000178053 HEK293_OSMI2_2hA HEK293_TMG_2hB MLF1 protein_coding nonsense_mediated_decay 15.36958 6.178075 24.17498 1.152746 1.024068 1.966549 7.7395523 2.8843892 11.718322 0.6400680 1.08282985 2.018666 0.47432917 0.4638000 0.48276667 0.01896667 9.433922e-01 1.164734e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178053 E001 0.0000000       3 158571163 158571163 1 +      
ENSG00000178053 E002 0.7427016 0.0153787590 1.887984e-01 0.3122389677 3 158571164 158571171 8 + 0.291 0.000 -10.863
ENSG00000178053 E003 0.8878743 0.0131564245 1.285025e-01 0.2320726086 3 158571172 158571172 1 + 0.331 0.000 -12.599
ENSG00000178053 E004 3.6998128 0.0052913124 9.320369e-01 0.9611849368 3 158571173 158571183 11 + 0.647 0.636 -0.045
ENSG00000178053 E005 5.1682761 0.0037185265 7.627854e-01 0.8463176455 3 158571184 158571190 7 + 0.775 0.735 -0.161
ENSG00000178053 E006 5.7520874 0.0188781331 7.809381e-01 0.8592398396 3 158571191 158571193 3 + 0.815 0.776 -0.153
ENSG00000178053 E007 5.7520874 0.0188781331 7.809381e-01 0.8592398396 3 158571194 158571194 1 + 0.815 0.776 -0.153
ENSG00000178053 E008 21.4607223 0.0009205678 3.589152e-02 0.0833736849 3 158571195 158571205 11 + 1.364 1.188 -0.618
ENSG00000178053 E009 30.6094620 0.0006982609 1.619059e-01 0.2776162900 3 158571206 158571209 4 + 1.491 1.396 -0.328
ENSG00000178053 E010 34.7412414 0.0005739213 3.173738e-01 0.4602416554 3 158571210 158571214 5 + 1.536 1.475 -0.211
ENSG00000178053 E011 68.3631077 0.0004056084 6.853452e-02 0.1409383007 3 158571215 158571253 39 + 1.830 1.748 -0.278
ENSG00000178053 E012 68.7024562 0.0004882261 9.291064e-02 0.1796819355 3 158571254 158571260 7 + 1.831 1.756 -0.254
ENSG00000178053 E013 113.1191099 0.0004441724 1.955470e-03 0.0070882034 3 158571261 158571347 87 + 2.052 1.939 -0.379
ENSG00000178053 E014 28.3777571 0.0037227809 9.316940e-01 0.9609673426 3 158571348 158571391 44 + 1.431 1.441 0.034
ENSG00000178053 E015 0.0000000       3 158571567 158571593 27 +      
ENSG00000178053 E016 0.2987644 0.0290785164 7.596608e-01   3 158572976 158573039 64 + 0.140 0.000 -11.067
ENSG00000178053 E017 0.2944980 0.4167909258 1.000000e+00   3 158573298 158573433 136 + 0.140 0.000 -10.528
ENSG00000178053 E018 0.2934659 0.0276393639 4.337420e-01   3 158582656 158582834 179 + 0.076 0.192 1.539
ENSG00000178053 E019 0.2955422 0.0276990610 4.347251e-01   3 158582835 158582929 95 + 0.076 0.192 1.539
ENSG00000178053 E020 9.2308959 0.0082913628 1.974749e-01 0.3230552895 3 158588852 158588859 8 + 1.015 0.851 -0.616
ENSG00000178053 E021 15.4850989 0.0011222859 2.881973e-02 0.0696457817 3 158588860 158588924 65 + 1.236 1.018 -0.781
ENSG00000178053 E022 168.1497502 0.0008706242 8.256721e-03 0.0244331631 3 158592434 158592581 148 + 2.215 2.132 -0.276
ENSG00000178053 E023 0.1472490 0.0448024456 1.000000e+00   3 158593382 158593421 40 + 0.076 0.000 -10.064
ENSG00000178053 E024 0.1472490 0.0448024456 1.000000e+00   3 158593422 158593426 5 + 0.076 0.000 -10.064
ENSG00000178053 E025 0.5891098 0.0182211078 2.848551e-01 0.4251351140 3 158596349 158596423 75 + 0.246 0.000 -12.042
ENSG00000178053 E026 136.6391402 0.0003093845 3.407485e-01 0.4846853211 3 158596862 158596945 84 + 2.110 2.082 -0.093
ENSG00000178053 E027 118.3297089 0.0009285763 4.800293e-01 0.6183499821 3 158598080 158598128 49 + 2.033 2.061 0.095
ENSG00000178053 E028 142.5113640 0.0003036706 2.733748e-01 0.4124002195 3 158598129 158598208 80 + 2.111 2.150 0.130
ENSG00000178053 E029 186.2951482 0.0003020372 3.312683e-02 0.0780597659 3 158600014 158600173 160 + 2.220 2.282 0.208
ENSG00000178053 E030 0.1451727 0.0438573887 1.000000e+00   3 158600174 158600175 2 + 0.076 0.000 -10.065
ENSG00000178053 E031 160.7306691 0.0002708373 5.066468e-02 0.1103389093 3 158602807 158602939 133 + 2.157 2.219 0.208
ENSG00000178053 E032 213.0005814 0.0019824799 3.818271e-05 0.0002211907 3 158605097 158607252 2156 + 2.254 2.384 0.434