ENSG00000178028

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315913 ENSG00000178028 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAP1 protein_coding protein_coding 42.70559 69.69849 31.17207 0.6538541 0.4287806 -1.160618 10.087969 23.813458 5.359546 1.56138288 0.90883968 -2.1495108 0.19323333 0.34193333 0.17213333 -0.16980000 6.912931e-03 8.928606e-17 FALSE TRUE
ENST00000372289 ENSG00000178028 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAP1 protein_coding protein_coding 42.70559 69.69849 31.17207 0.6538541 0.4287806 -1.160618 19.106195 30.710047 11.933778 0.91755207 0.38141883 -1.3629212 0.45251250 0.44053333 0.38273333 -0.05780000 1.088209e-01 8.928606e-17 FALSE TRUE
ENST00000446292 ENSG00000178028 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAP1 protein_coding protein_coding 42.70559 69.69849 31.17207 0.6538541 0.4287806 -1.160618 2.434428 3.534934 2.854253 1.05249868 0.76859255 -0.3075999 0.06598333 0.05056667 0.09106667 0.04050000 4.420564e-01 8.928606e-17 FALSE TRUE
ENST00000483741 ENSG00000178028 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAP1 protein_coding processed_transcript 42.70559 69.69849 31.17207 0.6538541 0.4287806 -1.160618 1.397831 1.332755 2.260694 0.08256378 0.19983647 0.7579370 0.03732917 0.01913333 0.07263333 0.05350000 4.511479e-10 8.928606e-17 FALSE FALSE
ENST00000488433 ENSG00000178028 HEK293_OSMI2_2hA HEK293_TMG_2hB DMAP1 protein_coding processed_transcript 42.70559 69.69849 31.17207 0.6538541 0.4287806 -1.160618 5.050978 3.748178 4.744406 0.25632855 0.04194443 0.3392317 0.13767500 0.05373333 0.15226667 0.09853333 8.928606e-17 8.928606e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000178028 E001 0.000000       1 44212922 44213090 169 +      
ENSG00000178028 E002 0.000000       1 44213091 44213363 273 +      
ENSG00000178028 E003 1.579187 0.0502329893 5.230103e-02 1.132555e-01 1 44213364 44213454 91 + 0.000 0.414 10.538
ENSG00000178028 E004 1.579187 0.0502329893 5.230103e-02 1.132555e-01 1 44213455 44213458 4 + 0.000 0.414 12.720
ENSG00000178028 E005 7.574302 0.0522927732 2.897054e-01 4.304209e-01 1 44213459 44213470 12 + 0.725 0.893 0.664
ENSG00000178028 E006 8.239684 0.0421198754 6.337047e-01 7.483463e-01 1 44213471 44213472 2 + 0.840 0.904 0.245
ENSG00000178028 E007 10.792381 0.0080928551 6.315637e-01 7.465423e-01 1 44213473 44213477 5 + 0.958 1.004 0.172
ENSG00000178028 E008 19.205720 0.0350388784 8.526214e-01 9.086829e-01 1 44213478 44213482 5 + 1.261 1.220 -0.143
ENSG00000178028 E009 21.481525 0.0261081350 6.800703e-01 7.840538e-01 1 44213483 44213483 1 + 1.321 1.260 -0.211
ENSG00000178028 E010 26.447648 0.0172998174 9.940506e-01 1.000000e+00 1 44213484 44213487 4 + 1.373 1.359 -0.048
ENSG00000178028 E011 76.642315 0.0078575168 9.665848e-01 9.830444e-01 1 44213488 44213502 15 + 1.820 1.811 -0.032
ENSG00000178028 E012 111.153614 0.0039626289 3.788265e-01 5.231176e-01 1 44213503 44213527 25 + 2.014 1.959 -0.183
ENSG00000178028 E013 62.191743 0.0004653798 7.713906e-01 8.524276e-01 1 44213528 44213549 22 + 1.721 1.724 0.009
ENSG00000178028 E014 144.121689 0.0012262003 4.313348e-01 5.738903e-01 1 44213550 44213662 113 + 2.118 2.077 -0.139
ENSG00000178028 E015 145.120777 0.0015829359 2.092853e-01 3.376723e-01 1 44213663 44213708 46 + 2.134 2.074 -0.201
ENSG00000178028 E016 211.883173 0.0049508359 2.097322e-02 5.353427e-02 1 44213709 44213748 40 + 2.335 2.225 -0.368
ENSG00000178028 E017 330.046220 0.0016902843 1.713169e-01 2.899060e-01 1 44213749 44213840 92 + 2.483 2.432 -0.172
ENSG00000178028 E018 204.752304 0.0002430321 6.254091e-01 7.415454e-01 1 44213841 44213858 18 + 2.257 2.231 -0.087
ENSG00000178028 E019 307.107812 0.0001527111 9.870991e-01 9.959892e-01 1 44214350 44214441 92 + 2.423 2.411 -0.039
ENSG00000178028 E020 3.414664 0.0155497218 1.500581e-04 7.472217e-04 1 44214442 44214538 97 + 0.958 0.376 -2.554
ENSG00000178028 E021 4.026588 0.0054572442 7.630692e-05 4.105568e-04 1 44214539 44214616 78 + 1.006 0.442 -2.370
ENSG00000178028 E022 3.574220 0.0042622318 3.384282e-05 1.986990e-04 1 44214617 44214702 86 + 0.983 0.376 -2.644
ENSG00000178028 E023 383.992116 0.0001793049 4.396275e-01 5.813795e-01 1 44214703 44214832 130 + 2.510 2.514 0.014
ENSG00000178028 E024 281.502242 0.0003579732 2.395598e-02 5.971250e-02 1 44214833 44214898 66 + 2.343 2.389 0.153
ENSG00000178028 E025 50.595459 0.0004718296 3.105881e-60 3.113226e-57 1 44214899 44215305 407 + 2.103 1.281 -2.798
ENSG00000178028 E026 347.323922 0.0026543704 2.846732e-58 2.737588e-55 1 44215306 44217989 2684 + 2.790 2.293 -1.656
ENSG00000178028 E027 56.285674 0.0024185039 2.801220e-09 3.825567e-08 1 44217990 44218194 205 + 1.909 1.583 -1.106
ENSG00000178028 E028 49.513546 0.0004511544 1.157207e-07 1.162280e-06 1 44218195 44218310 116 + 1.831 1.542 -0.978
ENSG00000178028 E029 229.824653 0.0002352841 4.449364e-04 1.947155e-03 1 44218311 44218340 30 + 2.223 2.310 0.289
ENSG00000178028 E030 226.775715 0.0001802415 3.820946e-04 1.705463e-03 1 44218341 44218364 24 + 2.215 2.302 0.292
ENSG00000178028 E031 395.682196 0.0001709687 3.309186e-03 1.117396e-02 1 44218365 44218469 105 + 2.484 2.534 0.165
ENSG00000178028 E032 499.276136 0.0001587703 2.029468e-02 5.209921e-02 1 44218588 44218755 168 + 2.602 2.633 0.103
ENSG00000178028 E033 532.437002 0.0008291764 3.923580e-07 3.542273e-06 1 44219056 44219241 186 + 2.575 2.676 0.335
ENSG00000178028 E034 200.738576 0.0011077904 2.013462e-03 7.267820e-03 1 44219406 44219419 14 + 2.162 2.254 0.306
ENSG00000178028 E035 327.760414 0.0001816662 5.735838e-05 3.183912e-04 1 44219420 44219477 58 + 2.379 2.461 0.274
ENSG00000178028 E036 12.194378 0.0056011054 2.504184e-02 6.196174e-02 1 44219780 44219805 26 + 1.220 0.977 -0.881
ENSG00000178028 E037 375.635585 0.0011975479 1.633964e-06 1.295404e-05 1 44219806 44219878 73 + 2.409 2.527 0.394
ENSG00000178028 E038 562.035792 0.0014610968 1.855788e-10 3.125932e-09 1 44220017 44220309 293 + 2.559 2.708 0.494
ENSG00000178028 E039 3.500851 0.1384068005 5.106786e-02 1.110740e-01 1 44220310 44220443 134 + 0.872 0.488 -1.631
ENSG00000178028 E040 190.389588 0.0027855142 1.035073e-04 5.382251e-04 1 44220559 44220681 123 + 2.094 2.240 0.489