ENSG00000177830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323578 ENSG00000177830 HEK293_OSMI2_2hA HEK293_TMG_2hB CHID1 protein_coding protein_coding 107.8995 169.3061 70.23254 8.350599 0.8729413 -1.269302 7.033834 9.972648 4.835179 0.2852564 0.2381215 -1.0428727 0.0690125 0.0592000 0.0688000 0.009600000 0.4941939229 0.0006246557 FALSE TRUE
ENST00000429789 ENSG00000177830 HEK293_OSMI2_2hA HEK293_TMG_2hB CHID1 protein_coding protein_coding 107.8995 169.3061 70.23254 8.350599 0.8729413 -1.269302 32.524431 50.337318 21.185349 0.8651793 0.5943624 -1.2481672 0.3013000 0.2985667 0.3017000 0.003133333 0.9818023605 0.0006246557 FALSE TRUE
ENST00000436108 ENSG00000177830 HEK293_OSMI2_2hA HEK293_TMG_2hB CHID1 protein_coding protein_coding 107.8995 169.3061 70.23254 8.350599 0.8729413 -1.269302 30.292569 55.967687 13.927152 1.6341440 1.4653248 -2.0059161 0.2606333 0.3313000 0.1981667 -0.133133333 0.0006246557 0.0006246557 FALSE TRUE
MSTRG.4934.30 ENSG00000177830 HEK293_OSMI2_2hA HEK293_TMG_2hB CHID1 protein_coding   107.8995 169.3061 70.23254 8.350599 0.8729413 -1.269302 18.997640 22.982699 14.672918 3.1813457 0.6313584 -0.6470371 0.1896958 0.1345000 0.2088667 0.074366667 0.0123937775 0.0006246557 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177830 E001 5.9492514 0.0112301128 4.522013e-04 1.975378e-03 11 867859 867859 1 - 1.089 0.622 -1.820
ENSG00000177830 E002 27.5244514 0.0213805959 7.215553e-05 3.906730e-04 11 867860 868394 535 - 1.647 1.250 -1.369
ENSG00000177830 E003 9.8724799 0.0116613768 2.001770e-04 9.644937e-04 11 868395 868398 4 - 1.253 0.822 -1.583
ENSG00000177830 E004 25.7613120 0.0130364839 2.152532e-03 7.697506e-03 11 868399 868439 41 - 1.549 1.270 -0.964
ENSG00000177830 E005 22.1767155 0.0060316013 1.051807e-03 4.138867e-03 11 868440 868445 6 - 1.489 1.209 -0.974
ENSG00000177830 E006 55.2056945 0.0091228516 1.608706e-02 4.293184e-02 11 868446 868521 76 - 1.795 1.626 -0.572
ENSG00000177830 E007 77.1434931 0.0091432542 1.960750e-01 3.213195e-01 11 868522 868613 92 - 1.877 1.791 -0.288
ENSG00000177830 E008 68.0648246 0.0059866056 1.507951e-01 2.627560e-01 11 868614 868671 58 - 1.829 1.737 -0.312
ENSG00000177830 E009 216.8679033 0.0006222308 1.135562e-01 2.107163e-01 11 868672 869213 542 - 2.296 2.242 -0.180
ENSG00000177830 E010 116.8086721 0.0002580225 7.516021e-04 3.084946e-03 11 869214 869345 132 - 2.085 1.953 -0.442
ENSG00000177830 E011 180.9542779 0.0010689081 2.567956e-04 1.203562e-03 11 869346 869761 416 - 2.269 2.140 -0.430
ENSG00000177830 E012 39.8247745 0.0091192604 8.706060e-03 2.555171e-02 11 869762 869762 1 - 1.674 1.470 -0.697
ENSG00000177830 E013 53.1134512 0.0048707127 1.640579e-02 4.362635e-02 11 869763 869766 4 - 1.763 1.606 -0.532
ENSG00000177830 E014 65.3479237 0.0044555570 2.601906e-01 3.976695e-01 11 869767 869779 13 - 1.791 1.718 -0.248
ENSG00000177830 E015 105.1074515 0.0002982957 3.648306e-01 5.091664e-01 11 869780 869796 17 - 1.917 1.947 0.101
ENSG00000177830 E016 293.9798447 0.0001984789 4.173523e-07 3.750232e-06 11 869797 869857 61 - 2.282 2.408 0.420
ENSG00000177830 E017 540.9493461 0.0006464075 1.526490e-08 1.818455e-07 11 869858 869956 99 - 2.552 2.672 0.400
ENSG00000177830 E018 321.5611880 0.0006611828 1.749662e-05 1.099507e-04 11 870121 870121 1 - 2.335 2.445 0.368
ENSG00000177830 E019 493.0052661 0.0006113230 2.643167e-07 2.474012e-06 11 870122 870163 42 - 2.520 2.631 0.371
ENSG00000177830 E020 703.0646717 0.0003715640 1.924613e-07 1.850353e-06 11 870419 870489 71 - 2.691 2.781 0.299
ENSG00000177830 E021 456.6491547 0.0001349805 1.462370e-04 7.309418e-04 11 870490 870499 10 - 2.518 2.589 0.236
ENSG00000177830 E022 6.5632977 0.0026130434 4.511934e-01 5.921691e-01 11 870500 870751 252 - 0.890 0.784 -0.414
ENSG00000177830 E023 11.9574508 0.0034318852 4.334508e-01 5.758684e-01 11 874646 874721 76 - 1.108 1.017 -0.332
ENSG00000177830 E024 23.5013162 0.0022578477 3.535142e-01 4.977569e-01 11 874722 874910 189 - 1.372 1.288 -0.290
ENSG00000177830 E025 33.0822900 0.0020975914 8.766933e-01 9.248528e-01 11 882142 882150 9 - 1.456 1.438 -0.065
ENSG00000177830 E026 64.3853861 0.0181494585 3.740206e-01 5.184348e-01 11 882151 882247 97 - 1.783 1.711 -0.244
ENSG00000177830 E027 41.5490281 0.0501822573 3.309346e-01 4.745061e-01 11 882248 882280 33 - 1.625 1.517 -0.367
ENSG00000177830 E028 51.5246658 0.0357644789 2.636039e-01 4.015224e-01 11 882281 882327 47 - 1.718 1.608 -0.373
ENSG00000177830 E029 105.6150209 0.0201566437 1.160626e-02 3.259661e-02 11 882328 882515 188 - 2.088 1.891 -0.663
ENSG00000177830 E030 6.2166350 0.1280742825 6.714672e-01 7.776753e-01 11 882980 883145 166 - 0.822 0.760 -0.247
ENSG00000177830 E031 4.4663369 0.1175048943 9.788156e-01 9.908345e-01 11 883146 883147 2 - 0.642 0.656 0.061
ENSG00000177830 E032 720.4845461 0.0001140269 3.918587e-02 8.952565e-02 11 883148 883199 52 - 2.752 2.778 0.086
ENSG00000177830 E033 992.5146054 0.0001265399 1.698691e-02 4.490503e-02 11 883200 883303 104 - 2.891 2.917 0.087
ENSG00000177830 E034 960.2903101 0.0001373531 1.500930e-04 7.473760e-04 11 884068 884169 102 - 2.859 2.907 0.159
ENSG00000177830 E035 595.0649288 0.0001212935 1.349912e-06 1.090236e-05 11 893427 893473 47 - 2.625 2.705 0.268
ENSG00000177830 E036 623.5895505 0.0001384036 1.674077e-10 2.845149e-09 11 893474 893519 46 - 2.622 2.730 0.361
ENSG00000177830 E037 434.2890290 0.0002974033 1.369483e-06 1.104264e-05 11 899340 899341 2 - 2.474 2.574 0.334
ENSG00000177830 E038 470.7392649 0.0010379550 1.936149e-04 9.364965e-04 11 899342 899352 11 - 2.519 2.607 0.292
ENSG00000177830 E039 720.1057885 0.0011357025 1.306527e-02 3.606431e-02 11 899353 899401 49 - 2.734 2.784 0.166
ENSG00000177830 E040 1017.2398417 0.0002843151 3.921616e-01 5.360963e-01 11 900004 900110 107 - 2.917 2.924 0.020
ENSG00000177830 E041 730.5028073 0.0006630867 3.634160e-01 5.078191e-01 11 900936 900980 45 - 2.797 2.773 -0.080
ENSG00000177830 E042 7.4359963 0.0407396852 2.176186e-03 7.768600e-03 11 902148 902196 49 - 1.145 0.699 -1.696
ENSG00000177830 E043 5.3302803 0.0107836238 1.456715e-03 5.496101e-03 11 902197 902197 1 - 1.025 0.583 -1.762
ENSG00000177830 E044 656.4342622 0.0001614398 5.115402e-02 1.112175e-01 11 902198 902225 28 - 2.763 2.723 -0.133
ENSG00000177830 E045 513.7784334 0.0001266662 7.329695e-02 1.487938e-01 11 902226 902234 9 - 2.656 2.616 -0.135
ENSG00000177830 E046 526.3765674 0.0001143631 1.704128e-01 2.887003e-01 11 902235 902244 10 - 2.661 2.629 -0.108
ENSG00000177830 E047 883.2978433 0.0001095567 1.261416e-01 2.287794e-01 11 902245 902330 86 - 2.883 2.854 -0.097
ENSG00000177830 E048 503.8941411 0.0013381624 6.428694e-01 7.555565e-01 11 902962 902970 9 - 2.633 2.615 -0.061
ENSG00000177830 E049 1047.2728539 0.0004582803 8.807131e-03 2.580242e-02 11 902971 903111 141 - 2.971 2.923 -0.160
ENSG00000177830 E050 0.2955422 0.0293297854 4.304626e-01   11 903656 903703 48 - 0.194 0.075 -1.586
ENSG00000177830 E051 2.8701118 0.0055599394 5.767915e-02 1.226446e-01 11 903704 903753 50 - 0.741 0.430 -1.412
ENSG00000177830 E052 3.1678441 0.0049383116 4.174997e-02 9.427408e-02 11 903754 903778 25 - 0.783 0.460 -1.431
ENSG00000177830 E053 0.2214452 0.0390462328 1.000000e+00   11 904701 904705 5 - 0.000 0.075 9.434
ENSG00000177830 E054 659.5226268 0.0011768449 2.396969e-07 2.263137e-06 11 904706 904736 31 - 2.825 2.704 -0.403
ENSG00000177830 E055 943.3031447 0.0007343975 3.477170e-14 1.056180e-12 11 904737 904859 123 - 2.995 2.854 -0.468
ENSG00000177830 E056 4.3973667 0.0062175154 1.506174e-01 2.625145e-01 11 904860 904864 5 - 0.822 0.603 -0.905
ENSG00000177830 E057 0.6663248 0.0647493473 2.896655e-01 4.303819e-01 11 908215 908296 82 - 0.000 0.242 11.191
ENSG00000177830 E058 153.8628954 0.0005060856 1.415785e-04 7.103749e-04 11 908542 908645 104 - 2.204 2.069 -0.449
ENSG00000177830 E059 0.7331471 0.0172671820 2.698759e-01 4.084293e-01 11 908646 908664 19 - 0.000 0.244 11.798
ENSG00000177830 E060 4.3887347 0.0037643887 3.406891e-02 7.989420e-02 11 910641 910774 134 - 0.890 0.582 -1.262
ENSG00000177830 E061 512.9051643 0.0010635248 7.934272e-10 1.199046e-08 11 910775 910884 110 - 2.736 2.587 -0.494
ENSG00000177830 E062 0.0000000       11 914304 914522 219 -      
ENSG00000177830 E063 0.0000000       11 914523 914744 222 -      
ENSG00000177830 E064 0.0000000       11 914745 914746 2 -      
ENSG00000177830 E065 0.0000000       11 914747 915058 312 -