ENSG00000177728

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314256 ENSG00000177728 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM94 protein_coding protein_coding 37.02765 45.7042 32.62603 3.443351 2.546606 -0.4861767 5.729801 7.609274 6.003221 2.1653909 0.8725444 -0.34151562 0.15158333 0.16353333 0.18983333 0.02630000 8.715839e-01 1.847655e-14 FALSE TRUE
ENST00000577247 ENSG00000177728 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM94 protein_coding protein_coding 37.02765 45.7042 32.62603 3.443351 2.546606 -0.4861767 5.696528 14.119018 1.462492 1.9749289 0.1405863 -3.26232989 0.13390000 0.30956667 0.04486667 -0.26470000 1.847655e-14 1.847655e-14 FALSE TRUE
ENST00000581085 ENSG00000177728 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM94 protein_coding retained_intron 37.02765 45.7042 32.62603 3.443351 2.546606 -0.4861767 3.231788 1.887655 2.767069 0.1448637 0.3921953 0.54934548 0.09343750 0.04183333 0.08500000 0.04316667 1.015364e-02 1.847655e-14 FALSE TRUE
ENST00000581723 ENSG00000177728 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM94 protein_coding retained_intron 37.02765 45.7042 32.62603 3.443351 2.546606 -0.4861767 4.116911 5.541187 4.668468 0.4690813 0.9934262 -0.24676026 0.10586667 0.12166667 0.13993333 0.01826667 8.150427e-01 1.847655e-14 FALSE FALSE
MSTRG.15072.2 ENSG00000177728 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM94 protein_coding   37.02765 45.7042 32.62603 3.443351 2.546606 -0.4861767 3.166800 3.005478 2.816045 0.5683722 0.7582445 -0.09360229 0.08742917 0.06766667 0.08350000 0.01583333 8.273741e-01 1.847655e-14 FALSE TRUE
MSTRG.15072.9 ENSG00000177728 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM94 protein_coding   37.02765 45.7042 32.62603 3.443351 2.546606 -0.4861767 2.212504 2.864393 1.586147 0.7496291 0.5947248 -0.84866403 0.06157917 0.06096667 0.04666667 -0.01430000 7.462435e-01 1.847655e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177728 E001 0.0000000       17 75441159 75441243 85 +      
ENSG00000177728 E002 0.1817044 0.0396930775 7.031817e-01   17 75456619 75456634 16 + 0.000 0.104 14.252
ENSG00000177728 E003 0.1817044 0.0396930775 7.031817e-01   17 75456635 75456640 6 + 0.000 0.104 14.270
ENSG00000177728 E004 0.1817044 0.0396930775 7.031817e-01   17 75456641 75456645 5 + 0.000 0.104 14.270
ENSG00000177728 E005 0.1817044 0.0396930775 7.031817e-01   17 75456646 75456646 1 + 0.000 0.104 14.270
ENSG00000177728 E006 0.1817044 0.0396930775 7.031817e-01   17 75456647 75456648 2 + 0.000 0.104 14.270
ENSG00000177728 E007 0.3289534 0.0291319408 7.663286e-01   17 75456649 75456649 1 + 0.143 0.104 -0.521
ENSG00000177728 E008 0.8491631 0.0154562631 3.721842e-01 5.166436e-01 17 75456650 75456652 3 + 0.336 0.189 -1.105
ENSG00000177728 E009 0.9943357 0.0121989077 1.914666e-01 3.155800e-01 17 75456653 75456653 1 + 0.408 0.189 -1.520
ENSG00000177728 E010 1.6930275 0.0082627989 5.248194e-01 6.582552e-01 17 75456654 75456659 6 + 0.470 0.373 -0.521
ENSG00000177728 E011 60.0015007 0.0009546193 3.008490e-14 9.221527e-13 17 75456660 75456751 92 + 1.946 1.610 -1.138
ENSG00000177728 E012 3.3578447 0.0454954126 2.023708e-02 5.198093e-02 17 75457294 75457477 184 + 0.835 0.460 -1.633
ENSG00000177728 E013 0.6976476 0.0545597895 6.996333e-01 7.992910e-01 17 75457478 75457685 208 + 0.250 0.189 -0.515
ENSG00000177728 E014 0.3332198 0.0295369381 7.656321e-01   17 75459707 75459770 64 + 0.143 0.104 -0.522
ENSG00000177728 E015 95.0188952 0.0060422793 2.781442e-06 2.097507e-05 17 75471800 75471863 64 + 2.086 1.866 -0.739
ENSG00000177728 E016 117.3798942 0.0024150655 9.944920e-07 8.254623e-06 17 75471864 75471929 66 + 2.152 1.979 -0.580
ENSG00000177728 E017 1.8196646 0.0087936121 3.345441e-01 4.782913e-01 17 75471930 75471955 26 + 0.524 0.373 -0.785
ENSG00000177728 E018 0.0000000       17 75476498 75476546 49 +      
ENSG00000177728 E019 0.0000000       17 75476547 75476689 143 +      
ENSG00000177728 E020 0.0000000       17 75476690 75476743 54 +      
ENSG00000177728 E021 0.3332198 0.0295369381 7.656321e-01   17 75485396 75485427 32 + 0.143 0.104 -0.522
ENSG00000177728 E022 141.9691254 0.0021783234 2.722413e-05 1.635857e-04 17 75485428 75485547 120 + 2.212 2.080 -0.442
ENSG00000177728 E023 0.2924217 0.0271650512 1.111392e-01   17 75485548 75485780 233 + 0.250 0.000 -16.587
ENSG00000177728 E024 107.3522432 0.0029084075 9.134753e-03 2.662004e-02 17 75485871 75485998 128 + 2.067 1.979 -0.295
ENSG00000177728 E025 8.3040781 0.1315457407 1.141395e-01 2.115687e-01 17 75485999 75486289 291 + 1.105 0.822 -1.058
ENSG00000177728 E026 83.3622404 0.0059349884 2.926704e-01 4.336460e-01 17 75486290 75486331 42 + 1.923 1.893 -0.101
ENSG00000177728 E027 70.8185969 0.0032484308 3.414372e-01 4.853332e-01 17 75486332 75486344 13 + 1.850 1.825 -0.084
ENSG00000177728 E028 124.0861003 0.0004963181 8.920370e-03 2.608169e-02 17 75486345 75486426 82 + 2.116 2.049 -0.222
ENSG00000177728 E029 0.7331366 0.0199553454 7.114893e-02 1.452473e-01 17 75487278 75487380 103 + 0.408 0.104 -2.523
ENSG00000177728 E030 176.1232334 0.0023146200 7.662214e-03 2.293326e-02 17 75487932 75488134 203 + 2.270 2.200 -0.234
ENSG00000177728 E031 124.4220671 0.0023273720 7.510885e-02 1.517031e-01 17 75488759 75488910 152 + 2.104 2.057 -0.155
ENSG00000177728 E032 128.8023501 0.0017650578 2.407511e-04 1.136489e-03 17 75489266 75489368 103 + 2.160 2.047 -0.379
ENSG00000177728 E033 116.3439556 0.0004584644 1.634133e-03 6.070584e-03 17 75489576 75489662 87 + 2.100 2.013 -0.291
ENSG00000177728 E034 1.7036261 0.0083208084 4.900563e-03 1.565250e-02 17 75489801 75489817 17 + 0.654 0.188 -2.692
ENSG00000177728 E035 5.9982907 0.0028100383 1.248637e-01 2.269331e-01 17 75490058 75490233 176 + 0.925 0.750 -0.681
ENSG00000177728 E036 100.6421067 0.0012512252 6.345244e-02 1.324468e-01 17 75490234 75490279 46 + 2.015 1.964 -0.171
ENSG00000177728 E037 114.7902649 0.0003385839 3.174823e-04 1.450701e-03 17 75490280 75490350 71 + 2.102 2.001 -0.339
ENSG00000177728 E038 99.2964513 0.0025910487 1.033513e-03 4.074414e-03 17 75490702 75490758 57 + 2.050 1.932 -0.395
ENSG00000177728 E039 129.0020425 0.0014201305 3.450265e-05 2.020709e-04 17 75491049 75491153 105 + 2.168 2.042 -0.422
ENSG00000177728 E040 119.4015206 0.0003002190 3.578643e-06 2.634094e-05 17 75491303 75491376 74 + 2.137 2.005 -0.444
ENSG00000177728 E041 133.1684932 0.0002805350 7.612672e-09 9.590994e-08 17 75491377 75491455 79 + 2.200 2.040 -0.535
ENSG00000177728 E042 27.6795118 0.0008298488 4.423020e-04 1.937182e-03 17 75491456 75491467 12 + 1.562 1.351 -0.726
ENSG00000177728 E043 74.7390414 0.0003585675 2.262236e-10 3.752507e-09 17 75491691 75491698 8 + 1.995 1.756 -0.806
ENSG00000177728 E044 170.3836609 0.0002114064 7.134554e-14 2.069228e-12 17 75491699 75491852 154 + 2.321 2.136 -0.619
ENSG00000177728 E045 84.4372641 0.0032198280 1.275106e-04 6.478529e-04 17 75491853 75491900 48 + 2.007 1.848 -0.534
ENSG00000177728 E046 11.5856836 0.0103943413 4.975110e-04 2.150644e-03 17 75491901 75492203 303 + 1.259 0.909 -1.270
ENSG00000177728 E047 4.1468585 0.0039208641 1.289209e-05 8.347176e-05 17 75492204 75492238 35 + 0.981 0.373 -2.660
ENSG00000177728 E048 4.2136678 0.0037465960 1.273019e-05 8.255840e-05 17 75492239 75492275 37 + 0.981 0.373 -2.659
ENSG00000177728 E049 4.8004832 0.0033808385 3.608301e-03 1.203404e-02 17 75492276 75492337 62 + 0.944 0.570 -1.522
ENSG00000177728 E050 4.8571018 0.0163615791 1.046975e-02 2.990748e-02 17 75492338 75492473 136 + 0.945 0.600 -1.389
ENSG00000177728 E051 147.6288924 0.0002504320 1.099823e-03 4.302788e-03 17 75492474 75492559 86 + 2.196 2.119 -0.257
ENSG00000177728 E052 210.1523176 0.0002324700 3.378762e-01 4.817536e-01 17 75492560 75492789 230 + 2.303 2.300 -0.011
ENSG00000177728 E053 8.3729772 0.0744655919 1.402904e-02 3.829074e-02 17 75492790 75492928 139 + 1.165 0.771 -1.475
ENSG00000177728 E054 192.1963452 0.0001913732 4.197990e-01 5.630579e-01 17 75492929 75493102 174 + 2.264 2.263 -0.001
ENSG00000177728 E055 49.4935944 0.0004758498 3.990258e-05 2.300495e-04 17 75493103 75493490 388 + 1.794 1.609 -0.626
ENSG00000177728 E056 167.9591484 0.0030983188 7.172713e-01 8.127088e-01 17 75493491 75493593 103 + 2.184 2.222 0.128
ENSG00000177728 E057 212.0945910 0.0005456519 7.223485e-01 8.164756e-01 17 75493699 75493916 218 + 2.288 2.319 0.105
ENSG00000177728 E058 126.5956830 0.0002562272 9.670345e-02 1.854363e-01 17 75494627 75494709 83 + 2.034 2.111 0.256
ENSG00000177728 E059 156.6804832 0.0002471275 8.854113e-02 1.728960e-01 17 75494710 75494808 99 + 2.128 2.201 0.242
ENSG00000177728 E060 0.4427912 0.1797752196 4.074052e-01 5.509790e-01 17 75494888 75494895 8 + 0.250 0.103 -1.536
ENSG00000177728 E061 205.5795890 0.0002418076 5.916338e-01 7.143673e-01 17 75494896 75495034 139 + 2.288 2.295 0.025
ENSG00000177728 E062 100.7908771 0.0003084006 9.095454e-01 9.465474e-01 17 75495284 75495286 3 + 1.969 1.994 0.085
ENSG00000177728 E063 191.4098527 0.0002247800 2.592275e-01 3.966135e-01 17 75495287 75495399 113 + 2.267 2.258 -0.030
ENSG00000177728 E064 1.6337955 0.0124659773 1.094478e-02 3.102876e-02 17 75495542 75495543 2 + 0.615 0.189 -2.520
ENSG00000177728 E065 158.5815888 0.0004072438 5.423575e-01 6.731279e-01 17 75495544 75495643 100 + 2.182 2.185 0.010
ENSG00000177728 E066 0.8921407 0.0135219245 1.842188e-03 6.733754e-03 17 75495644 75495965 322 + 0.524 0.000 -18.173
ENSG00000177728 E067 172.8662631 0.0010038881 8.247131e-01 8.895688e-01 17 75495966 75496074 109 + 2.211 2.226 0.051
ENSG00000177728 E068 4.1086077 0.0120015974 4.358454e-01 5.779958e-01 17 75496075 75496281 207 + 0.754 0.656 -0.405
ENSG00000177728 E069 147.3826218 0.0003250224 9.597182e-01 9.786984e-01 17 75496282 75496333 52 + 2.137 2.157 0.066
ENSG00000177728 E070 222.1347215 0.0010201186 2.610747e-01 3.986990e-01 17 75496334 75496471 138 + 2.293 2.347 0.181
ENSG00000177728 E071 0.7394793 0.0156257559 7.016324e-02 1.436360e-01 17 75496728 75496729 2 + 0.408 0.104 -2.523
ENSG00000177728 E072 143.0935573 0.0030809855 2.362215e-01 3.698009e-01 17 75496730 75496807 78 + 2.094 2.164 0.234
ENSG00000177728 E073 159.7353230 0.0042337961 4.043716e-01 5.480829e-01 17 75497113 75497165 53 + 2.150 2.207 0.193
ENSG00000177728 E074 131.1549730 0.0005081907 1.177609e-01 2.167333e-01 17 75497166 75497198 33 + 2.050 2.124 0.248
ENSG00000177728 E075 110.3607158 0.0002600317 3.577074e-02 8.314001e-02 17 75497781 75497802 22 + 1.961 2.057 0.322
ENSG00000177728 E076 174.5980225 0.0003940879 1.628394e-02 4.335213e-02 17 75497803 75497862 60 + 2.163 2.255 0.306
ENSG00000177728 E077 180.1434416 0.0003242491 7.555500e-04 3.099404e-03 17 75498175 75498216 42 + 2.159 2.277 0.395
ENSG00000177728 E078 178.4962903 0.0002170365 2.455504e-04 1.156729e-03 17 75498217 75498261 45 + 2.148 2.274 0.420
ENSG00000177728 E079 198.7367226 0.0001967345 7.566634e-06 5.166983e-05 17 75498262 75498323 62 + 2.183 2.325 0.476
ENSG00000177728 E080 118.2453862 0.0002757695 8.537288e-05 4.533986e-04 17 75498444 75498455 12 + 1.948 2.107 0.533
ENSG00000177728 E081 228.8232189 0.0009315777 4.914331e-05 2.774152e-04 17 75498456 75498538 83 + 2.248 2.386 0.463
ENSG00000177728 E082 10.2337967 0.0030021293 6.723505e-01 7.783414e-01 17 75498539 75498547 9 + 1.047 1.022 -0.093
ENSG00000177728 E083 17.9994217 0.0269809016 6.055388e-01 7.258994e-01 17 75498548 75498628 81 + 1.210 1.289 0.277
ENSG00000177728 E084 238.0782909 0.0022417923 4.214448e-06 3.048664e-05 17 75498629 75498722 94 + 2.237 2.416 0.598
ENSG00000177728 E085 7.0231982 0.0024253971 1.805780e-03 6.617397e-03 17 75498723 75498911 189 + 1.076 0.728 -1.329
ENSG00000177728 E086 296.2162937 0.0001600832 4.961924e-16 1.951467e-14 17 75498912 75499082 171 + 2.310 2.515 0.683
ENSG00000177728 E087 5.6138917 0.0210973942 7.346571e-01 8.255643e-01 17 75499083 75499118 36 + 0.836 0.806 -0.117
ENSG00000177728 E088 900.3452016 0.0079787563 6.564160e-09 8.374709e-08 17 75499262 75500452 1191 + 2.745 3.020 0.913