ENSG00000177707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000485303 ENSG00000177707 HEK293_OSMI2_2hA HEK293_TMG_2hB NECTIN3 protein_coding protein_coding 15.68931 1.645558 26.46282 0.08313883 0.5378773 3.999123 4.6181866 1.1047424 8.343050 0.09077709 0.2996907 2.905593 0.38117083 0.67463333 0.3155667 -0.35906667 2.269671e-05 4.706192e-19 FALSE TRUE
ENST00000491525 ENSG00000177707 HEK293_OSMI2_2hA HEK293_TMG_2hB NECTIN3 protein_coding protein_coding 15.68931 1.645558 26.46282 0.08313883 0.5378773 3.999123 5.7941064 0.0000000 9.798400 0.00000000 0.5073441 9.937874 0.24459583 0.00000000 0.3699333 0.36993333 4.706192e-19 4.706192e-19 FALSE FALSE
ENST00000493615 ENSG00000177707 HEK293_OSMI2_2hA HEK293_TMG_2hB NECTIN3 protein_coding protein_coding 15.68931 1.645558 26.46282 0.08313883 0.5378773 3.999123 0.3339089 0.3290687 0.000000 0.12275486 0.0000000 -5.083506 0.08940833 0.19570000 0.0000000 -0.19570000 2.061732e-08 4.706192e-19 FALSE TRUE
MSTRG.23420.3 ENSG00000177707 HEK293_OSMI2_2hA HEK293_TMG_2hB NECTIN3 protein_coding   15.68931 1.645558 26.46282 0.08313883 0.5378773 3.999123 2.6024036 0.1450138 4.750280 0.07252225 0.2764820 4.940578 0.13795000 0.09266667 0.1800333 0.08736667 4.534122e-01 4.706192e-19 FALSE TRUE
MSTRG.23420.7 ENSG00000177707 HEK293_OSMI2_2hA HEK293_TMG_2hB NECTIN3 protein_coding   15.68931 1.645558 26.46282 0.08313883 0.5378773 3.999123 2.1342955 0.0000000 3.325144 0.00000000 0.4818092 8.381605 0.11770417 0.00000000 0.1251000 0.12510000 5.694535e-06 4.706192e-19 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177707 E001 0.0000000       3 111070071 111070106 36 +      
ENSG00000177707 E002 0.0000000       3 111070115 111070329 215 +      
ENSG00000177707 E003 5.9212873 0.0341504306 6.852860e-02 1.409307e-01 3 111071808 111071815 8 + 0.725 0.292 -2.168
ENSG00000177707 E004 11.7333820 0.0117946376 8.571942e-03 2.521942e-02 3 111071816 111071867 52 + 0.978 0.465 -2.151
ENSG00000177707 E005 14.1065577 0.0015794593 2.383292e-02 5.946836e-02 3 111071868 111072019 152 + 1.044 0.684 -1.393
ENSG00000177707 E006 3.4490971 0.0061346497 7.127053e-01 8.093582e-01 3 111072020 111072021 2 + 0.507 0.588 0.377
ENSG00000177707 E007 33.1948855 0.0064272389 3.562662e-01 5.006532e-01 3 111072022 111072167 146 + 1.368 1.283 -0.297
ENSG00000177707 E008 20.8000284 0.0009700854 4.430669e-01 5.846342e-01 3 111072168 111072177 10 + 1.177 1.097 -0.290
ENSG00000177707 E009 0.0000000       3 111072178 111072493 316 +      
ENSG00000177707 E010 0.0000000       3 111072494 111072510 17 +      
ENSG00000177707 E011 0.0000000       3 111072511 111072987 477 +      
ENSG00000177707 E012 0.2214452 0.0403651582 3.588718e-02   3 111073416 111073491 76 + 0.000 0.292 12.798
ENSG00000177707 E013 0.0000000       3 111074204 111074250 47 +      
ENSG00000177707 E014 0.0000000       3 111074895 111075242 348 +      
ENSG00000177707 E015 0.4449813 0.0213976155 2.515769e-01 3.878337e-01 3 111077185 111077277 93 + 0.087 0.291 2.113
ENSG00000177707 E016 0.0000000       3 111112010 111112029 20 +      
ENSG00000177707 E017 124.2842482 0.0003162669 1.095880e-01 2.049671e-01 3 111112030 111112371 342 + 1.925 1.857 -0.231
ENSG00000177707 E018 167.8763088 0.0002262442 6.397583e-02 1.333117e-01 3 111118656 111118952 297 + 2.053 1.986 -0.224
ENSG00000177707 E019 93.2511706 0.0003078187 1.217346e-01 2.224068e-01 3 111122121 111122238 118 + 1.801 1.722 -0.267
ENSG00000177707 E020 124.3772069 0.0002469926 1.821184e-01 3.038682e-01 3 111126184 111126335 152 + 1.923 1.868 -0.184
ENSG00000177707 E021 67.3016275 0.0003875757 5.212545e-01 6.551299e-01 3 111133635 111133660 26 + 1.658 1.625 -0.110
ENSG00000177707 E022 424.5617434 0.0008908014 6.264656e-09 8.031537e-08 3 111133661 111137560 3900 + 2.428 2.563 0.451
ENSG00000177707 E023 24.4183694 0.0008131755 6.373359e-01 7.512436e-01 3 111144899 111145037 139 + 1.226 1.283 0.202
ENSG00000177707 E024 21.4701151 0.0009542937 7.579418e-01 8.426286e-01 3 111147403 111147484 82 + 1.184 1.159 -0.089
ENSG00000177707 E025 17.5494513 0.0043659978 1.350454e-02 3.708625e-02 3 111192351 111192413 63 + 1.130 0.762 -1.385
ENSG00000177707 E026 28.5333450 0.0153637768 6.580031e-01 7.672436e-01 3 111193200 111193373 174 + 1.302 1.259 -0.151
ENSG00000177707 E027 35.2934373 0.0575985596 8.758925e-01 9.242911e-01 3 111193374 111193690 317 + 1.385 1.377 -0.026
ENSG00000177707 E028 0.6621601 0.0164643786 4.715066e-02 1.040944e-01 3 111228659 111228717 59 + 0.087 0.465 3.115
ENSG00000177707 E029 0.1451727 0.0436377781 6.622733e-01   3 111275313 111275563 251 + 0.046 0.000 -9.583