ENSG00000177706

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313766 ENSG00000177706 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM20C protein_coding protein_coding 8.582652 12.27425 6.288179 0.799129 0.2091476 -0.9638027 2.4672818 2.986389 2.9805553 0.5024773 0.11404120 -0.002811747 0.2915667 0.24043333 0.47590000 0.23546667 0.0008999589 0.0008999589 FALSE TRUE
ENST00000471328 ENSG00000177706 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM20C protein_coding processed_transcript 8.582652 12.27425 6.288179 0.799129 0.2091476 -0.9638027 0.8233083 1.145662 0.3495512 0.1949198 0.07041539 -1.684450134 0.0986750 0.09213333 0.05496667 -0.03716667 0.2576127769 0.0008999589 FALSE FALSE
MSTRG.29348.2 ENSG00000177706 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM20C protein_coding   8.582652 12.27425 6.288179 0.799129 0.2091476 -0.9638027 4.9856887 8.039848 2.8422084 0.3057296 0.19328694 -1.496882089 0.5726667 0.65936667 0.45130000 -0.20806667 0.0102863956 0.0008999589 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177706 E001 35.5148135 0.0333951988 2.654444e-07 2.483709e-06 7 192571 193534 964 + 1.814 1.289 -1.799
ENSG00000177706 E002 55.1347676 0.0005466998 2.085887e-06 1.616415e-05 7 193535 193804 270 + 1.854 1.625 -0.775
ENSG00000177706 E003 0.0000000       7 195242 195327 86 +      
ENSG00000177706 E004 44.7763272 0.0037865518 5.361885e-01 6.679377e-01 7 195554 195624 71 + 1.646 1.605 -0.140
ENSG00000177706 E005 61.4365883 0.0005275931 6.186564e-01 7.362342e-01 7 195625 195732 108 + 1.770 1.742 -0.094
ENSG00000177706 E006 11.2181171 0.0016602035 1.305682e-02 3.604375e-02 7 197130 197575 446 + 0.832 1.110 1.038
ENSG00000177706 E007 52.3316056 0.0009402632 6.863736e-01 7.888964e-01 7 208898 208976 79 + 1.699 1.674 -0.085
ENSG00000177706 E008 0.3332198 0.0284540127 6.534204e-01   7 245895 246414 520 + 0.160 0.093 -0.909
ENSG00000177706 E009 67.2104536 0.0115392008 8.273882e-01 8.914696e-01 7 246415 246507 93 + 1.805 1.789 -0.055
ENSG00000177706 E010 78.9379709 0.0021860073 4.422907e-01 5.839377e-01 7 248315 248430 116 + 1.890 1.852 -0.130
ENSG00000177706 E011 118.6015403 0.0003875728 8.831218e-03 2.585894e-02 7 255849 256029 181 + 2.100 2.010 -0.300
ENSG00000177706 E012 1.2115146 0.0136396889 2.421715e-01 3.767556e-01 7 256195 256653 459 + 0.444 0.234 -1.318
ENSG00000177706 E013 92.5528262 0.0050758137 1.376809e-01 2.448463e-01 7 256654 256763 110 + 1.986 1.912 -0.248
ENSG00000177706 E014 81.6258494 0.0035226429 8.730193e-01 9.223942e-01 7 257005 257086 82 + 1.877 1.882 0.016
ENSG00000177706 E015 1.4726134 0.0216996041 5.700705e-01 6.965869e-01 7 257087 257453 367 + 0.444 0.340 -0.585
ENSG00000177706 E016 62.0065606 0.0009704018 1.620388e-01 2.777687e-01 7 258646 258705 60 + 1.714 1.778 0.216
ENSG00000177706 E017 281.6387749 0.0013227024 1.962483e-17 9.236931e-16 7 259731 260772 1042 + 2.259 2.468 0.697