ENSG00000177679

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000479294 ENSG00000177679 HEK293_OSMI2_2hA HEK293_TMG_2hB SRRM3 protein_coding retained_intron 2.258894 4.093285 2.502043 0.1499112 0.4629407 -0.7079185 0.06266523 0.0000000 0.2691203 0.00000000 0.26912030 4.802815 0.04429167 0.00000000 0.07923333 0.07923333 7.075713e-01 1.170219e-09 FALSE FALSE
ENST00000611745 ENSG00000177679 HEK293_OSMI2_2hA HEK293_TMG_2hB SRRM3 protein_coding protein_coding 2.258894 4.093285 2.502043 0.1499112 0.4629407 -0.7079185 0.43104469 0.3311154 0.8499926 0.07929114 0.08634578 1.334065 0.21048750 0.07966667 0.36713333 0.28746667 2.133021e-03 1.170219e-09 FALSE TRUE
ENST00000612155 ENSG00000177679 HEK293_OSMI2_2hA HEK293_TMG_2hB SRRM3 protein_coding retained_intron 2.258894 4.093285 2.502043 0.1499112 0.4629407 -0.7079185 1.68509440 3.6368498 1.2611346 0.04631582 0.20739808 -1.520534 0.70742500 0.89010000 0.50846667 -0.38163333 1.170219e-09 1.170219e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177679 E001 3.2987276 0.0049932155 4.225952e-06 3.056402e-05 7 76201896 76202067 172 + 0.922 0.198 -3.673
ENSG00000177679 E002 0.0000000       7 76234982 76235027 46 +      
ENSG00000177679 E003 6.7687383 0.0026128634 6.191196e-11 1.129421e-09 7 76235028 76235299 272 + 1.196 0.333 -3.672
ENSG00000177679 E004 4.6178510 0.0035089092 1.110298e-05 7.300775e-05 7 76248188 76248289 102 + 1.008 0.388 -2.672
ENSG00000177679 E005 5.3037436 0.0033984703 1.479246e-04 7.380724e-04 7 76259906 76260034 129 + 1.023 0.519 -2.051
ENSG00000177679 E006 4.5896497 0.0036055426 6.663997e-05 3.638674e-04 7 76260117 76260197 81 + 0.992 0.436 -2.351
ENSG00000177679 E007 3.6266343 0.0046806322 9.652313e-04 3.839261e-03 7 76260874 76260903 30 + 0.882 0.388 -2.198
ENSG00000177679 E008 5.5547389 0.0039279170 7.616232e-04 3.120871e-03 7 76261352 76261414 63 + 1.023 0.589 -1.730
ENSG00000177679 E009 5.5398765 0.0037965632 7.657881e-04 3.135360e-03 7 76261546 76261581 36 + 1.023 0.589 -1.730
ENSG00000177679 E010 5.0938630 0.0033513891 3.371706e-03 1.135492e-02 7 76264765 76264815 51 + 0.976 0.589 -1.553
ENSG00000177679 E011 3.9985627 0.0046958820 5.446659e-03 1.714498e-02 7 76265364 76265406 43 + 0.882 0.480 -1.713
ENSG00000177679 E012 4.2951371 0.0045605009 1.868926e-03 6.818729e-03 7 76265407 76265468 62 + 0.922 0.480 -1.865
ENSG00000177679 E013 4.9186997 0.0038411851 3.747500e-02 8.635737e-02 7 76267258 76267435 178 + 0.902 0.620 -1.138
ENSG00000177679 E014 6.0136303 0.0749733887 6.460270e-01 7.580587e-01 7 76267436 76269992 2557 + 0.881 0.797 -0.325
ENSG00000177679 E015 0.6224193 0.0180435596 8.192085e-01 8.858367e-01 7 76273053 76273595 543 + 0.239 0.198 -0.352
ENSG00000177679 E016 3.1000542 0.0606079245 2.695046e-02 6.588914e-02 7 76281441 76281802 362 + 0.788 0.391 -1.817
ENSG00000177679 E017 0.2214452 0.0384748145 5.968844e-01   7 76282614 76282647 34 + 0.000 0.110 8.191
ENSG00000177679 E018 9.0847316 0.0294264545 4.080269e-03 1.336876e-02 7 76282648 76282872 225 + 1.174 0.796 -1.409
ENSG00000177679 E019 13.1187716 0.0044614480 7.339380e-01 8.250499e-01 7 76282964 76283101 138 + 1.164 1.127 -0.134
ENSG00000177679 E020 9.3965515 0.0122811896 5.331399e-01 6.653870e-01 7 76283524 76283602 79 + 0.975 1.043 0.247
ENSG00000177679 E021 167.3297810 0.0007532303 2.118868e-44 9.557457e-42 7 76285615 76287288 1674 + 2.038 2.300 0.879