ENSG00000177565

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352800 ENSG00000177565 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL1XR1 protein_coding protein_coding 7.729138 2.819611 9.991237 1.030186 0.3304982 1.821503 1.33139362 0.03498209 1.06919082 0.03498209 0.34838084 4.584455 0.10372500 0.01840000 0.109633333 0.09123333 1.224904e-01 1.716946e-08 FALSE TRUE
ENST00000474363 ENSG00000177565 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL1XR1 protein_coding retained_intron 7.729138 2.819611 9.991237 1.030186 0.3304982 1.821503 0.42657929 0.09680863 0.63267704 0.03681000 0.12862229 2.589066 0.06609167 0.03666667 0.062666667 0.02600000 5.763441e-01 1.716946e-08 FALSE FALSE
ENST00000636864 ENSG00000177565 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL1XR1 protein_coding processed_transcript 7.729138 2.819611 9.991237 1.030186 0.3304982 1.821503 0.08669807 0.28534355 0.00000000 0.14368552 0.00000000 -4.884322 0.03831250 0.10113333 0.000000000 -0.10113333 1.389917e-02 1.716946e-08 FALSE TRUE
ENST00000637659 ENSG00000177565 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL1XR1 protein_coding nonsense_mediated_decay 7.729138 2.819611 9.991237 1.030186 0.3304982 1.821503 0.43661716 1.43279636 0.09029976 0.79171381 0.04933067 -3.846478 0.14291250 0.44743333 0.008733333 -0.43870000 1.716946e-08 1.716946e-08 TRUE TRUE
ENST00000673974 ENSG00000177565 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL1XR1 protein_coding protein_coding 7.729138 2.819611 9.991237 1.030186 0.3304982 1.821503 3.12490094 0.58131874 5.03587773 0.10999476 0.44687372 3.093097 0.37796250 0.23260000 0.502100000 0.26950000 1.718577e-03 1.716946e-08 FALSE TRUE
MSTRG.24097.10 ENSG00000177565 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL1XR1 protein_coding   7.729138 2.819611 9.991237 1.030186 0.3304982 1.821503 0.42085120 0.03582860 0.83877751 0.01881068 0.01809983 4.211066 0.03743750 0.02030000 0.084200000 0.06390000 6.229481e-04 1.716946e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177565 E001 0.0000000       3 177019340 177019343 4 -      
ENSG00000177565 E002 0.0000000       3 177019344 177019354 11 -      
ENSG00000177565 E003 13.9238331 0.0013268566 1.386536e-09 2.002250e-08 3 177019355 177020591 1237 - 0.847 1.531 2.451
ENSG00000177565 E004 3.9251821 0.0328981076 5.037542e-02 1.098327e-01 3 177020592 177020753 162 - 0.485 0.924 1.848
ENSG00000177565 E005 2.4303288 0.0064815378 1.937023e-03 7.031429e-03 3 177020754 177020771 18 - 0.278 0.881 2.877
ENSG00000177565 E006 295.4201897 0.0660730742 4.325681e-04 1.899688e-03 3 177020772 177022475 1704 - 2.198 2.726 1.759
ENSG00000177565 E007 59.1581326 0.0016971111 2.514628e-01 3.877123e-01 3 177022476 177022925 450 - 1.636 1.696 0.204
ENSG00000177565 E008 149.4394427 0.0002215804 1.288622e-01 2.325715e-01 3 177022926 177024765 1840 - 2.031 2.110 0.265
ENSG00000177565 E009 30.7040785 0.0212063923 1.597579e-01 2.747951e-01 3 177024766 177024854 89 - 1.315 1.574 0.893
ENSG00000177565 E010 78.1731270 0.0142336003 3.533054e-01 4.975407e-01 3 177024855 177025344 490 - 1.755 1.800 0.152
ENSG00000177565 E011 43.0401885 0.0049682971 2.095324e-01 3.379847e-01 3 177025345 177025524 180 - 1.506 1.532 0.089
ENSG00000177565 E012 0.2924217 0.0275194536 1.000000e+00   3 177025985 177026041 57 - 0.099 0.000 -11.789
ENSG00000177565 E013 32.7444477 0.0281792679 3.965161e-01 5.402675e-01 3 177026373 177026420 48 - 1.391 1.402 0.037
ENSG00000177565 E014 37.4015250 0.0006057375 1.270436e-01 2.300232e-01 3 177026421 177026470 50 - 1.448 1.463 0.051
ENSG00000177565 E015 26.1945413 0.0007823303 5.332114e-02 1.150634e-01 3 177026471 177026474 4 - 1.312 1.263 -0.171
ENSG00000177565 E016 9.8679032 0.0030757742 2.582919e-01 3.955238e-01 3 177026475 177027830 1356 - 0.920 0.881 -0.148
ENSG00000177565 E017 2.0767031 0.0067735657 4.217731e-02 9.505096e-02 3 177032318 177032340 23 - 0.447 0.000 -14.401
ENSG00000177565 E018 2.0809695 0.0185266810 4.495859e-02 1.001218e-01 3 177032552 177032597 46 - 0.447 0.000 -14.347
ENSG00000177565 E019 1.9400632 0.1365959163 9.427247e-02 1.817941e-01 3 177032606 177032659 54 - 0.427 0.000 -13.866
ENSG00000177565 E020 33.0272454 0.0010344113 2.698193e-02 6.595842e-02 3 177032971 177033010 40 - 1.407 1.351 -0.192
ENSG00000177565 E021 40.0142477 0.0005292015 1.611350e-02 4.298771e-02 3 177033011 177033136 126 - 1.488 1.438 -0.174
ENSG00000177565 E022 35.8391279 0.0005890011 6.421994e-04 2.688009e-03 3 177034198 177034325 128 - 1.456 1.300 -0.540
ENSG00000177565 E023 0.4449813 0.0217681645 4.810715e-01 6.193135e-01 3 177037637 177037842 206 - 0.099 0.261 1.683
ENSG00000177565 E024 35.8913477 0.0005883019 2.832648e-02 6.865521e-02 3 177038098 177038172 75 - 1.440 1.397 -0.151
ENSG00000177565 E025 42.0545342 0.0038367851 3.155324e-01 4.582976e-01 3 177038313 177038428 116 - 1.492 1.542 0.172
ENSG00000177565 E026 22.0060409 0.0010489224 2.131515e-01 3.422605e-01 3 177038429 177038434 6 - 1.235 1.243 0.028
ENSG00000177565 E027 0.0000000       3 177041072 177041181 110 -      
ENSG00000177565 E028 30.9407764 0.0022627535 1.570571e-01 2.711837e-01 3 177046129 177046189 61 - 1.373 1.382 0.032
ENSG00000177565 E029 31.9525629 0.0176416666 3.905281e-01 5.344894e-01 3 177047300 177047397 98 - 1.380 1.412 0.112
ENSG00000177565 E030 26.9963084 0.0167805741 2.203225e-01 3.508025e-01 3 177047486 177047549 64 - 1.317 1.302 -0.054
ENSG00000177565 E031 39.7848093 0.0005767067 6.226420e-03 1.920915e-02 3 177049997 177050138 142 - 1.490 1.411 -0.273
ENSG00000177565 E032 26.9141914 0.0008122699 5.313298e-03 1.678543e-02 3 177050478 177050549 72 - 1.336 1.200 -0.477
ENSG00000177565 E033 15.0964366 0.0012625928 3.232718e-02 7.648846e-02 3 177050550 177050557 8 - 1.103 0.966 -0.502
ENSG00000177565 E034 19.2264319 0.0009836843 2.014578e-02 5.179066e-02 3 177050558 177050601 44 - 1.198 1.069 -0.461
ENSG00000177565 E035 11.8449134 0.0015186294 3.545510e-03 1.185549e-02 3 177050602 177050610 9 - 1.021 0.710 -1.203
ENSG00000177565 E036 20.4780686 0.0008959932 9.015802e-03 2.631767e-02 3 177051504 177051535 32 - 1.225 1.069 -0.558
ENSG00000177565 E037 20.7392823 0.0008762483 7.337026e-03 2.209374e-02 3 177051536 177051554 19 - 1.232 1.069 -0.581
ENSG00000177565 E038 19.3957289 0.0010578981 3.633215e-02 8.421345e-02 3 177051555 177051570 16 - 1.198 1.099 -0.354
ENSG00000177565 E039 20.4903012 0.0010017148 1.721766e-02 4.542501e-02 3 177051571 177051614 44 - 1.225 1.099 -0.451
ENSG00000177565 E040 16.4170978 0.0010867915 6.062742e-02 1.276882e-01 3 177051615 177051641 27 - 1.129 1.037 -0.331
ENSG00000177565 E041 20.6460793 0.0009336242 2.506783e-01 3.867505e-01 3 177051642 177051670 29 - 1.208 1.222 0.049
ENSG00000177565 E042 20.2367879 0.0010829485 7.797708e-02 1.562271e-01 3 177051671 177051686 16 - 1.208 1.152 -0.198
ENSG00000177565 E043 18.9833148 0.0010124039 4.692026e-02 1.036812e-01 3 177051687 177051700 14 - 1.187 1.099 -0.316
ENSG00000177565 E044 20.5354256 0.0008966894 6.536209e-02 1.356468e-01 3 177051701 177051726 26 - 1.215 1.152 -0.223
ENSG00000177565 E045 17.2137978 0.0010369880 1.633548e-02 4.346622e-02 3 177053773 177053791 19 - 1.157 1.003 -0.557
ENSG00000177565 E046 26.9989731 0.0007167682 1.006591e-03 3.981120e-03 3 177053792 177053877 86 - 1.343 1.152 -0.673
ENSG00000177565 E047 19.8888086 0.0243529819 1.853702e-02 4.831184e-02 3 177053878 177053918 41 - 1.218 1.004 -0.770
ENSG00000177565 E048 21.1661305 0.3823497732 1.249047e-01 2.269901e-01 3 177064920 177064978 59 - 1.247 1.005 -0.869
ENSG00000177565 E049 20.1079631 0.1794455815 1.857229e-01 3.084100e-01 3 177064979 177065022 44 - 1.218 1.045 -0.620
ENSG00000177565 E050 0.1515154 0.0445414344 1.000000e+00   3 177078632 177078778 147 - 0.052 0.000 -10.722
ENSG00000177565 E051 0.0000000       3 177079454 177079826 373 -      
ENSG00000177565 E052 2.4296164 0.2471364623 7.860603e-01 8.629904e-01 3 177079827 177079886 60 - 0.446 0.425 -0.113
ENSG00000177565 E053 2.0984730 0.0195735346 2.780366e-01 4.176700e-01 3 177079887 177079945 59 - 0.426 0.261 -1.015
ENSG00000177565 E054 0.2987644 0.0276067148 1.000000e+00   3 177086965 177087041 77 - 0.099 0.000 -11.788
ENSG00000177565 E055 0.3030308 0.4058958566 1.000000e+00   3 177091151 177091180 30 - 0.100 0.000 -10.881
ENSG00000177565 E056 10.9102001 0.0308645290 1.314410e-01 2.361481e-01 3 177098466 177098470 5 - 0.971 0.832 -0.528
ENSG00000177565 E057 12.9095839 0.0045253968 4.222989e-02 9.514231e-02 3 177098471 177098486 16 - 1.037 0.881 -0.582
ENSG00000177565 E058 14.7408923 0.0847902500 1.680350e-01 2.856477e-01 3 177098487 177098541 55 - 1.091 0.930 -0.593
ENSG00000177565 E059 0.0000000       3 177099405 177099447 43 -      
ENSG00000177565 E060 0.4396707 0.0339395091 8.333441e-01 8.955998e-01 3 177110809 177110887 79 - 0.141 0.000 -12.303
ENSG00000177565 E061 0.8984834 0.0669462004 3.169160e-01 4.597256e-01 3 177131363 177131376 14 - 0.248 0.000 -13.074
ENSG00000177565 E062 0.5997190 0.1507601856 6.015056e-01 7.226421e-01 3 177131377 177131377 1 - 0.180 0.000 -12.264
ENSG00000177565 E063 1.3704194 0.0202566657 6.183802e-01 7.360304e-01 3 177131378 177131449 72 - 0.307 0.261 -0.315
ENSG00000177565 E064 0.0000000       3 177136217 177136245 29 -      
ENSG00000177565 E065 2.2594371 0.0089427496 7.014456e-01 8.006143e-01 3 177160871 177160988 118 - 0.382 0.541 0.812
ENSG00000177565 E066 0.0000000       3 177163978 177164001 24 -      
ENSG00000177565 E067 0.0000000       3 177171390 177171417 28 -      
ENSG00000177565 E068 0.0000000       3 177194064 177194126 63 -      
ENSG00000177565 E069 0.1482932 0.0411597534 8.338042e-02   3 177195588 177195664 77 - 0.000 0.261 13.632
ENSG00000177565 E070 1.3316977 0.1501172072 1.906109e-01 3.145254e-01 3 177196340 177196484 145 - 0.334 0.000 -13.355
ENSG00000177565 E071 11.3229015 0.0095360892 1.408833e-01 2.492371e-01 3 177197121 177197482 362 - 0.977 0.882 -0.358
ENSG00000177565 E072 0.0000000       3 177201739 177201817 79 -      
ENSG00000177565 E073 0.0000000       3 177227868 177228000 133 -