ENSG00000177410

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371743 ENSG00000177410 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAS1 lncRNA lncRNA 41.50578 37.8204 62.89289 8.327835 1.577837 0.7335803 8.594608 9.181249 13.556940 2.5625794 0.76427980 0.5617626 0.1995667 0.23606667 0.21563333 -0.02043333 7.334864e-01 5.63665e-18 TRUE FALSE
ENST00000410433 ENSG00000177410 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAS1 lncRNA snoRNA 41.50578 37.8204 62.89289 8.327835 1.577837 0.7335803 3.209783 1.448167 7.614823 0.7274948 0.66700242 2.3865482 0.0724875 0.03376667 0.12110000 0.08733333 3.270809e-01 5.63665e-18   FALSE
ENST00000417721 ENSG00000177410 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAS1 lncRNA lncRNA 41.50578 37.8204 62.89289 8.327835 1.577837 0.7335803 4.732159 7.088258 4.178103 1.4847879 0.09140753 -0.7611680 0.1247167 0.18793333 0.06653333 -0.12140000 5.636650e-18 5.63665e-18 TRUE FALSE
ENST00000441722 ENSG00000177410 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAS1 lncRNA lncRNA 41.50578 37.8204 62.89289 8.327835 1.577837 0.7335803 7.452070 10.044129 7.881432 3.1513906 0.26718883 -0.3494291 0.1830042 0.25670000 0.12563333 -0.13106667 9.644760e-05 5.63665e-18 TRUE FALSE
ENST00000623640 ENSG00000177410 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAS1 lncRNA lncRNA 41.50578 37.8204 62.89289 8.327835 1.577837 0.7335803 4.253521 1.741917 5.456052 0.2340638 0.28384514 1.6415648 0.1101833 0.04783333 0.08673333 0.03890000 5.478599e-04 5.63665e-18   FALSE
ENST00000667889 ENSG00000177410 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAS1 lncRNA lncRNA 41.50578 37.8204 62.89289 8.327835 1.577837 0.7335803 10.199569 4.347782 20.784768 0.6778557 1.02125604 2.2545546 0.2308042 0.12103333 0.33006667 0.20903333 2.954355e-06 5.63665e-18   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177410 E001 0.9159869 0.0167343912 7.086290e-02 1.447824e-01 20 49278178 49278270 93 + 0.435 0.116 -2.488
ENSG00000177410 E002 2.9118563 0.0051436049 6.137489e-01 7.323907e-01 20 49278271 49278397 127 + 0.648 0.575 -0.321
ENSG00000177410 E003 0.6299079 0.0210142996 2.685724e-01 4.070549e-01 20 49278398 49278426 29 + 0.308 0.116 -1.752
ENSG00000177410 E004 5.2086672 0.0056183525 6.949492e-01 7.956586e-01 20 49278427 49278639 213 + 0.836 0.793 -0.172
ENSG00000177410 E005 4.7583597 0.0462498662 6.067127e-01 7.267961e-01 20 49278640 49278641 2 + 0.710 0.809 0.396
ENSG00000177410 E006 1072.5375458 0.0001273121 5.586902e-03 1.751861e-02 20 49278642 49278716 75 + 3.054 3.025 -0.098
ENSG00000177410 E007 69.0401610 0.0127981662 3.181621e-01 4.611165e-01 20 49278717 49278738 22 + 1.816 1.865 0.167
ENSG00000177410 E008 1114.9996375 0.0001195605 4.408003e-02 9.852905e-02 20 49279104 49279115 12 + 3.066 3.046 -0.068
ENSG00000177410 E009 1351.4670339 0.0000734961 1.621505e-01 2.779189e-01 20 49279116 49279173 58 + 3.145 3.134 -0.035
ENSG00000177410 E010 1200.2903986 0.0001075516 4.018965e-01 5.455971e-01 20 49279174 49279208 35 + 3.091 3.084 -0.023
ENSG00000177410 E011 11.1853657 0.0544015931 2.385739e-04 1.127253e-03 20 49279209 49279655 447 + 1.323 0.726 -2.212
ENSG00000177410 E012 5.3572256 0.2080106808 2.579963e-01 3.951980e-01 20 49280319 49280321 3 + 0.952 0.622 -1.319
ENSG00000177410 E013 8.8270579 0.0433406371 4.417777e-02 9.871956e-02 20 49280322 49280484 163 + 1.139 0.818 -1.196
ENSG00000177410 E014 875.2283446 0.0007031453 4.713092e-01 6.104377e-01 20 49280485 49280570 86 + 2.955 2.941 -0.045
ENSG00000177410 E015 24.8948425 0.0069662438 1.416424e-01 2.502866e-01 20 49280571 49280682 112 + 1.482 1.376 -0.365
ENSG00000177410 E016 33.8858988 0.0023297213 1.064220e-09 1.570075e-08 20 49280683 49280902 220 + 1.722 1.328 -1.352
ENSG00000177410 E017 295.9897474 0.0009385427 2.111330e-01 3.398546e-01 20 49280903 49280964 62 + 2.496 2.467 -0.097
ENSG00000177410 E018 30.8116323 0.0006444257 2.664601e-12 6.104736e-11 20 49280965 49281181 217 + 1.702 1.260 -1.520
ENSG00000177410 E019 28.0470652 0.0071694786 8.013099e-12 1.693883e-10 20 49281752 49281818 67 + 1.692 1.133 -1.938
ENSG00000177410 E020 1013.4656639 0.0001946952 1.108756e-36 3.079920e-34 20 49289045 49290860 1816 + 2.920 3.073 0.512
ENSG00000177410 E021 2.0166824 0.0569026087 6.729173e-01 7.787358e-01 20 49290888 49291148 261 + 0.435 0.499 0.325
ENSG00000177410 E022 9.7547292 0.1158272274 8.373979e-03 2.472261e-02 20 49295403 49299600 4198 + 0.710 1.165 1.722