ENSG00000177311

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000510338 ENSG00000177311 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB38 protein_coding protein_coding 2.230853 0.628451 3.521969 0.09738338 0.1855654 2.467825 0.76516766 0.03180926 1.3091417 0.02634793 0.08630413 4.979633 0.22341667 0.04966667 0.3737000 0.3240333 0.0005598771 0.0005598771 FALSE TRUE
ENST00000512769 ENSG00000177311 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB38 protein_coding processed_transcript 2.230853 0.628451 3.521969 0.09738338 0.1855654 2.467825 0.02464507 0.14421289 0.0000000 0.14421289 0.00000000 -3.946851 0.03354583 0.18040000 0.0000000 -0.1804000 0.4259624950 0.0005598771   FALSE
ENST00000514251 ENSG00000177311 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB38 protein_coding protein_coding 2.230853 0.628451 3.521969 0.09738338 0.1855654 2.467825 0.20350747 0.00000000 0.5615624 0.00000000 0.06572107 5.836839 0.09586667 0.00000000 0.1606667 0.1606667 0.0023280086 0.0005598771 FALSE TRUE
ENST00000637056 ENSG00000177311 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB38 protein_coding protein_coding 2.230853 0.628451 3.521969 0.09738338 0.1855654 2.467825 0.91674988 0.38787593 1.2920329 0.05008224 0.06091665 1.710375 0.47618750 0.67130000 0.3670667 -0.3042333 0.3551593308 0.0005598771 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177311 E001 0.2903454 0.3026430139 1.000000e+00   3 141324213 141324456 244 + 0.103 0.000 -10.464
ENSG00000177311 E002 0.0000000       3 141368304 141368323 20 +      
ENSG00000177311 E003 0.0000000       3 141368324 141368443 120 +      
ENSG00000177311 E004 0.0000000       3 141368444 141368489 46 +      
ENSG00000177311 E005 0.0000000       3 141368490 141368503 14 +      
ENSG00000177311 E006 0.0000000       3 141368504 141368620 117 +      
ENSG00000177311 E007 0.5911862 0.0172671820 5.289551e-01 6.618106e-01 3 141368621 141368804 184 + 0.187 0.000 -13.158
ENSG00000177311 E008 0.9566712 0.2713469877 4.268201e-01 5.696397e-01 3 141369872 141369946 75 + 0.187 0.412 1.554
ENSG00000177311 E009 0.4762024 0.2524477732 4.871812e-01 6.248739e-01 3 141381425 141381487 63 + 0.103 0.253 1.552
ENSG00000177311 E010 0.0000000       3 141383660 141383709 50 +      
ENSG00000177311 E011 0.0000000       3 141384810 141384875 66 +      
ENSG00000177311 E012 0.0000000       3 141385921 141386058 138 +      
ENSG00000177311 E013 0.2903454 0.3026430139 1.000000e+00   3 141386442 141386445 4 + 0.103 0.000 -11.762
ENSG00000177311 E014 0.2903454 0.3026430139 1.000000e+00   3 141386446 141386451 6 + 0.103 0.000 -11.762
ENSG00000177311 E015 1.0267148 0.0153921543 6.591325e-02 1.365595e-01 3 141386452 141386755 304 + 0.147 0.527 2.549
ENSG00000177311 E016 0.0000000       3 141386756 141386871 116 +      
ENSG00000177311 E017 0.7363694 0.0202237606 1.138870e-02 3.209357e-02 3 141386872 141386874 3 + 0.055 0.527 4.134
ENSG00000177311 E018 0.7363694 0.0202237606 1.138870e-02 3.209357e-02 3 141386875 141386878 4 + 0.055 0.527 4.134
ENSG00000177311 E019 1.4329979 0.4466559591 2.916265e-02 7.031406e-02 3 141386879 141386937 59 + 0.104 0.768 4.166
ENSG00000177311 E020 0.1515154 0.0428941520 1.000000e+00   3 141386938 141387440 503 + 0.055 0.000 -11.263
ENSG00000177311 E021 0.3289534 0.0287736963 2.490763e-01   3 141387441 141387646 206 + 0.055 0.252 2.547
ENSG00000177311 E022 0.2987644 0.0274381031 1.000000e+00   3 141387647 141387811 165 + 0.104 0.000 -12.247
ENSG00000177311 E023 0.0000000       3 141387812 141387887 76 +      
ENSG00000177311 E024 0.1817044 0.0392738649 8.136044e-02   3 141387888 141390034 2147 + 0.000 0.252 14.252
ENSG00000177311 E025 0.0000000       3 141392719 141392870 152 +      
ENSG00000177311 E026 0.9566832 0.0132966767 7.453801e-03 2.239545e-02 3 141394200 141394457 258 + 0.104 0.617 3.545
ENSG00000177311 E027 0.1472490 0.0434491200 1.000000e+00   3 141396259 141396503 245 + 0.055 0.000 -11.260
ENSG00000177311 E028 1.0986217 0.0829460000 1.343914e-01 2.402616e-01 3 141402349 141402369 21 + 0.187 0.526 2.129
ENSG00000177311 E029 3.7859770 0.1091776228 9.380197e-01 9.650539e-01 3 141402370 141402449 80 + 0.582 0.617 0.154
ENSG00000177311 E030 0.5891098 0.0183156452 5.300355e-01 6.627293e-01 3 141402818 141403152 335 + 0.187 0.000 -13.153
ENSG00000177311 E031 9.5032344 0.0023862307 1.012811e-01 1.924225e-01 3 141403927 141404031 105 + 0.931 0.758 -0.675
ENSG00000177311 E032 0.1515154 0.0428941520 1.000000e+00   3 141405726 141405756 31 + 0.055 0.000 -11.263
ENSG00000177311 E033 0.0000000       3 141426116 141426126 11 +      
ENSG00000177311 E034 0.0000000       3 141426127 141426165 39 +      
ENSG00000177311 E035 0.1451727 0.0428748319 1.000000e+00   3 141427634 141427821 188 + 0.055 0.000 -11.263
ENSG00000177311 E036 0.0000000       3 141431723 141432243 521 +      
ENSG00000177311 E037 0.1451727 0.0428748319 1.000000e+00   3 141438243 141438267 25 + 0.055 0.000 -11.263
ENSG00000177311 E038 1.4812505 0.0094394517 1.081990e-01 2.028760e-01 3 141438268 141438365 98 + 0.370 0.000 -14.221
ENSG00000177311 E039 207.3532273 0.0008684324 2.727514e-27 3.610897e-25 3 141442389 141446893 4505 + 2.225 2.018 -0.693
ENSG00000177311 E040 18.8956711 0.0010407469 7.508178e-01 8.374128e-01 3 141446894 141447049 156 + 1.160 1.263 0.363
ENSG00000177311 E041 41.7257650 0.0008705023 3.813020e-04 1.702487e-03 3 141447050 141447635 586 + 1.444 1.730 0.977
ENSG00000177311 E042 62.8537628 0.0433698029 1.536927e-05 9.785128e-05 3 141447636 141449792 2157 + 1.561 2.030 1.585