ENSG00000177303

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321617 ENSG00000177303 HEK293_OSMI2_2hA HEK293_TMG_2hB CASKIN2 protein_coding protein_coding 8.615741 11.31068 5.965485 0.856098 0.2496913 -0.9218334 6.8112533 9.7054944 4.1574259 0.53237356 0.16184841 -1.2211309 0.7788125 0.86176667 0.7001667 -0.1616000 0.0734524294 0.0005943846 FALSE  
ENST00000580021 ENSG00000177303 HEK293_OSMI2_2hA HEK293_TMG_2hB CASKIN2 protein_coding retained_intron 8.615741 11.31068 5.965485 0.856098 0.2496913 -0.9218334 0.8906299 0.6059314 0.9304235 0.27877402 0.25426814 0.6105409 0.1079458 0.05153333 0.1544000 0.1028667 0.1117182408 0.0005943846 TRUE  
ENST00000581870 ENSG00000177303 HEK293_OSMI2_2hA HEK293_TMG_2hB CASKIN2 protein_coding protein_coding 8.615741 11.31068 5.965485 0.856098 0.2496913 -0.9218334 0.3140619 0.2183421 0.4890244 0.01294631 0.08328055 1.1279136 0.0432375 0.01950000 0.0822000 0.0627000 0.0005943846 0.0005943846 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177303 E001 157.002163 0.0116538145 7.648798e-04 3.131980e-03 17 75500261 75500784 524 - 1.967 2.190 0.746
ENSG00000177303 E002 50.332676 0.0105163417 6.039011e-02 1.272747e-01 17 75500785 75500807 23 - 1.532 1.692 0.543
ENSG00000177303 E003 42.157021 0.0137413285 1.080480e-01 2.026409e-01 17 75500808 75500808 1 - 1.463 1.616 0.523
ENSG00000177303 E004 188.983669 0.0038086232 2.177806e-04 1.039949e-03 17 75500809 75501170 362 - 2.091 2.258 0.560
ENSG00000177303 E005 118.988963 0.0040033305 2.760229e-04 1.282068e-03 17 75501468 75501690 223 - 1.873 2.064 0.641
ENSG00000177303 E006 288.929285 0.0002181502 4.387527e-11 8.219974e-10 17 75501779 75503089 1311 - 2.266 2.438 0.575
ENSG00000177303 E007 86.265608 0.0018574508 2.865456e-01 4.269618e-01 17 75503090 75503254 165 - 1.827 1.892 0.219
ENSG00000177303 E008 89.235767 0.0052803719 3.084844e-01 4.507771e-01 17 75503389 75503527 139 - 1.917 1.882 -0.117
ENSG00000177303 E009 6.890582 0.0800297538 3.776223e-02 8.688927e-02 17 75503528 75503658 131 - 1.062 0.726 -1.287
ENSG00000177303 E010 70.475967 0.0003915990 2.136415e-02 5.435708e-02 17 75503659 75503760 102 - 1.855 1.764 -0.305
ENSG00000177303 E011 67.558171 0.0005637306 1.441090e-01 2.536021e-01 17 75503852 75503962 111 - 1.810 1.755 -0.186
ENSG00000177303 E012 51.242888 0.0006456080 5.508963e-02 1.181567e-01 17 75504215 75504306 92 - 1.721 1.632 -0.300
ENSG00000177303 E013 39.342253 0.0030478308 4.355964e-01 5.778113e-01 17 75504420 75504480 61 - 1.575 1.537 -0.127
ENSG00000177303 E014 47.546681 0.0089243272 5.860333e-01 7.096703e-01 17 75504572 75504693 122 - 1.586 1.640 0.184
ENSG00000177303 E015 40.241202 0.0007190287 7.931239e-01 8.677232e-01 17 75504812 75504907 96 - 1.526 1.556 0.102
ENSG00000177303 E016 54.934280 0.0043782710 1.987804e-01 3.246718e-01 17 75504908 75505073 166 - 1.725 1.665 -0.203
ENSG00000177303 E017 3.653522 0.0043431372 4.638033e-01 6.035716e-01 17 75505319 75505556 238 - 0.700 0.598 -0.437
ENSG00000177303 E018 45.356415 0.0005783580 1.253306e-02 3.481147e-02 17 75505557 75505651 95 - 1.691 1.565 -0.427
ENSG00000177303 E019 69.480230 0.0004000054 2.769834e-02 6.741656e-02 17 75505821 75505929 109 - 1.852 1.766 -0.291
ENSG00000177303 E020 71.248785 0.0003740086 6.969930e-03 2.114570e-02 17 75506305 75506413 109 - 1.873 1.766 -0.361
ENSG00000177303 E021 59.969370 0.0004687765 2.546102e-03 8.900906e-03 17 75506583 75506666 84 - 1.820 1.688 -0.446
ENSG00000177303 E022 41.826092 0.0035819398 3.375740e-01 4.814568e-01 17 75506667 75506713 47 - 1.608 1.561 -0.161
ENSG00000177303 E023 1.101843 0.3746738598 6.466818e-01 7.585104e-01 17 75506743 75506798 56 - 0.397 0.261 -0.858
ENSG00000177303 E024 48.793088 0.0050099221 2.231056e-01 3.540990e-01 17 75506799 75506894 96 - 1.682 1.619 -0.212
ENSG00000177303 E025 45.756423 0.0172969552 1.561638e-01 2.700301e-01 17 75506984 75507129 146 - 1.681 1.579 -0.348
ENSG00000177303 E026 42.488151 0.0011294813 7.106489e-03 2.150275e-02 17 75507584 75507681 98 - 1.673 1.530 -0.488
ENSG00000177303 E027 0.000000       17 75507682 75507851 170 -      
ENSG00000177303 E028 47.325473 0.0017686774 5.054605e-06 3.593304e-05 17 75508234 75508285 52 - 1.782 1.543 -0.812
ENSG00000177303 E029 0.000000       17 75509725 75509888 164 -      
ENSG00000177303 E030 35.932299 0.0006499882 2.308398e-04 1.095181e-03 17 75513711 75513727 17 - 1.649 1.439 -0.720
ENSG00000177303 E031 125.903339 0.0015642122 6.809172e-08 7.144313e-07 17 75513728 75514208 481 - 2.167 1.984 -0.612
ENSG00000177303 E032 3.857168 0.1260442510 2.766077e-01 4.160580e-01 17 75514209 75514250 42 - 0.398 0.680 1.332
ENSG00000177303 E033 1.101841 0.0114484114 4.863054e-01 6.240846e-01 17 75515212 75515400 189 - 0.176 0.314 1.080
ENSG00000177303 E034 25.511713 0.0094239604 9.819850e-01 9.927388e-01 17 75515401 75515590 190 - 1.343 1.359 0.056