ENSG00000177225

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319863 ENSG00000177225 HEK293_OSMI2_2hA HEK293_TMG_2hB GATD1 protein_coding protein_coding 74.58515 110.0756 39.26058 9.637676 2.90749 -1.487106 25.080140 37.830839 12.575943 3.5495483 0.30565467 -1.5881307 0.33021667 0.34336667 0.32370000 -0.019666667 0.8040500852 2.737295e-09 FALSE  
ENST00000526325 ENSG00000177225 HEK293_OSMI2_2hA HEK293_TMG_2hB GATD1 protein_coding protein_coding 74.58515 110.0756 39.26058 9.637676 2.90749 -1.487106 4.672607 7.220798 2.407691 0.6043677 0.86219419 -1.5805251 0.06406667 0.06573333 0.06470000 -0.001033333 0.8862685518 2.737295e-09 FALSE  
ENST00000528309 ENSG00000177225 HEK293_OSMI2_2hA HEK293_TMG_2hB GATD1 protein_coding protein_coding 74.58515 110.0756 39.26058 9.637676 2.90749 -1.487106 6.100907 11.879992 2.417284 0.9002601 0.07579655 -2.2923326 0.07338333 0.11063333 0.06253333 -0.048100000 0.0886144813 2.737295e-09 FALSE  
ENST00000528602 ENSG00000177225 HEK293_OSMI2_2hA HEK293_TMG_2hB GATD1 protein_coding retained_intron 74.58515 110.0756 39.26058 9.637676 2.90749 -1.487106 6.940852 5.860870 4.603543 1.1369287 1.85940252 -0.3476991 0.10252500 0.05236667 0.11163333 0.059266667 0.4341693767 2.737295e-09 FALSE  
ENST00000532320 ENSG00000177225 HEK293_OSMI2_2hA HEK293_TMG_2hB GATD1 protein_coding retained_intron 74.58515 110.0756 39.26058 9.637676 2.90749 -1.487106 9.369018 10.394453 6.290844 1.5464193 0.75158747 -0.7235842 0.13275417 0.09350000 0.15923333 0.065733333 0.0001321706 2.737295e-09 FALSE  
MSTRG.4919.14 ENSG00000177225 HEK293_OSMI2_2hA HEK293_TMG_2hB GATD1 protein_coding   74.58515 110.0756 39.26058 9.637676 2.90749 -1.487106 4.713480 7.691095 3.308169 1.6192589 0.24573928 -1.2146761 0.06605417 0.06880000 0.08586667 0.017066667 0.6564777530 2.737295e-09 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177225 E001 8.527738 0.0022942069 9.140672e-01 9.495743e-01 11 766022 766047 26 - 0.864 0.894 0.117
ENSG00000177225 E002 9.973265 0.0018672073 1.939803e-01 3.187978e-01 11 766048 766079 32 - 0.790 0.978 0.721
ENSG00000177225 E003 15.240071 0.0107957303 8.234017e-01 8.887159e-01 11 766759 766761 3 - 1.134 1.126 -0.028
ENSG00000177225 E004 15.196064 0.0214838177 8.410101e-01 9.007980e-01 11 766762 766763 2 - 1.134 1.126 -0.030
ENSG00000177225 E005 21.211174 0.0009685493 4.090195e-01 5.526250e-01 11 766764 766788 25 - 1.299 1.246 -0.187
ENSG00000177225 E006 19.100234 0.0010493123 9.891577e-01 9.972788e-01 11 766789 766791 3 - 1.202 1.218 0.058
ENSG00000177225 E007 20.056917 0.0010418773 8.891317e-01 9.331161e-01 11 766792 766799 8 - 1.232 1.237 0.018
ENSG00000177225 E008 29.934435 0.0007036367 4.360726e-01 5.782041e-01 11 766800 766884 85 - 1.428 1.389 -0.137
ENSG00000177225 E009 19.968775 0.0010485967 6.084369e-01 7.281617e-01 11 766885 766894 10 - 1.246 1.218 -0.099
ENSG00000177225 E010 39.258713 0.0190639510 4.829427e-01 6.210345e-01 11 766895 767013 119 - 1.438 1.533 0.327
ENSG00000177225 E011 45.287936 0.0162197462 6.015283e-02 1.268636e-01 11 767188 767219 32 - 1.410 1.610 0.686
ENSG00000177225 E012 36.044972 0.0230659627 1.381495e-01 2.455067e-01 11 767220 767221 2 - 1.324 1.511 0.645
ENSG00000177225 E013 37.224117 0.0251821935 8.949291e-02 1.743556e-01 11 767222 767224 3 - 1.312 1.529 0.748
ENSG00000177225 E014 37.372410 0.0257342227 8.761606e-02 1.715174e-01 11 767225 767227 3 - 1.312 1.531 0.756
ENSG00000177225 E015 182.071511 0.0038082317 1.049939e-05 6.946805e-05 11 767228 767293 66 - 1.986 2.212 0.758
ENSG00000177225 E016 430.051396 0.0062792130 2.829970e-05 1.693289e-04 11 767294 767368 75 - 2.372 2.582 0.700
ENSG00000177225 E017 309.145871 0.0060299125 1.999555e-03 7.224642e-03 11 767369 767373 5 - 2.266 2.432 0.555
ENSG00000177225 E018 2399.524086 0.0021253176 1.679102e-03 6.216063e-03 11 767374 770313 2940 - 3.222 3.307 0.285
ENSG00000177225 E019 327.591604 0.0002051998 8.762583e-01 9.245793e-01 11 770314 770398 85 - 2.408 2.423 0.053
ENSG00000177225 E020 278.198796 0.0034605824 2.881278e-02 6.963077e-02 11 770399 770469 71 - 2.397 2.341 -0.190
ENSG00000177225 E021 285.506562 0.0009665726 1.846392e-05 1.154777e-04 11 770470 770549 80 - 2.438 2.339 -0.327
ENSG00000177225 E022 350.268308 0.0004852568 6.332786e-05 3.476967e-04 11 770550 770678 129 - 2.508 2.433 -0.250
ENSG00000177225 E023 188.642517 0.0020063017 2.494121e-03 8.746342e-03 11 770679 770697 19 - 2.250 2.162 -0.292
ENSG00000177225 E024 368.064714 0.0022073125 8.682757e-04 3.502965e-03 11 770698 770811 114 - 2.532 2.456 -0.254
ENSG00000177225 E025 227.920066 0.0009076087 5.504455e-06 3.881206e-05 11 770812 770843 32 - 2.352 2.236 -0.385
ENSG00000177225 E026 244.957217 0.0010752257 1.158016e-04 5.946459e-04 11 770844 770903 60 - 2.368 2.273 -0.315
ENSG00000177225 E027 170.236218 0.0016764439 6.939562e-04 2.876949e-03 11 770904 770992 89 - 2.214 2.113 -0.338
ENSG00000177225 E028 236.428564 0.0015004255 2.549464e-01 3.917244e-01 11 770993 771034 42 - 2.291 2.276 -0.049
ENSG00000177225 E029 254.253148 0.0009978179 4.918609e-02 1.077091e-01 11 771035 771104 70 - 2.340 2.303 -0.125
ENSG00000177225 E030 68.788927 0.0151737072 3.832332e-03 1.267187e-02 11 771105 771212 108 - 1.904 1.701 -0.685
ENSG00000177225 E031 59.459094 0.0005415307 3.604364e-08 3.994594e-07 11 771213 771332 120 - 1.875 1.618 -0.870
ENSG00000177225 E032 418.193678 0.0001357687 1.375967e-01 2.447380e-01 11 771333 771426 94 - 2.487 2.538 0.170
ENSG00000177225 E033 29.672456 0.0006767374 9.256113e-02 1.791249e-01 11 771427 771467 41 - 1.472 1.368 -0.359
ENSG00000177225 E034 451.791613 0.0003863950 3.609228e-01 5.052978e-01 11 772427 772521 95 - 2.527 2.568 0.137
ENSG00000177225 E035 10.922075 0.0818816088 4.221337e-01 5.652968e-01 11 772522 772614 93 - 1.076 0.958 -0.436
ENSG00000177225 E036 15.751635 0.0011744268 6.365267e-09 8.148548e-08 11 773330 773427 98 - 1.464 0.978 -1.725
ENSG00000177225 E037 20.923282 0.0085160358 4.282222e-05 2.451734e-04 11 773428 773521 94 - 1.497 1.152 -1.206
ENSG00000177225 E038 455.558098 0.0001619602 4.921981e-01 6.293862e-01 11 773522 773629 108 - 2.537 2.570 0.112
ENSG00000177225 E039 492.848486 0.0003204713 1.723862e-01 2.913087e-01 11 774008 774113 106 - 2.561 2.609 0.161
ENSG00000177225 E040 2.763662 0.0059274957 3.729920e-02 8.603493e-02 11 775065 775065 1 - 0.747 0.425 -1.465
ENSG00000177225 E041 366.721101 0.0004869457 8.318019e-01 8.945869e-01 11 775066 775142 77 - 2.461 2.475 0.049
ENSG00000177225 E042 29.823955 0.0072073469 2.740303e-01 4.131270e-01 11 776680 777179 500 - 1.446 1.376 -0.244
ENSG00000177225 E043 300.416700 0.0002119005 3.081265e-01 4.503791e-01 11 777399 777488 90 - 2.389 2.383 -0.021