ENSG00000177156

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319006 ENSG00000177156 HEK293_OSMI2_2hA HEK293_TMG_2hB TALDO1 protein_coding protein_coding 232.1145 375.9247 145.0515 43.36734 2.767908 -1.373817 168.88915 283.67618 95.20571 37.528770 2.898255 -1.5750244 0.7169792 0.7511667 0.6561667 -0.0950 0.002779786 0.002494174 FALSE  
ENST00000528097 ENSG00000177156 HEK293_OSMI2_2hA HEK293_TMG_2hB TALDO1 protein_coding protein_coding 232.1145 375.9247 145.0515 43.36734 2.767908 -1.373817 42.67261 59.48441 35.76232 2.071791 1.348880 -0.7339102 0.1928083 0.1623333 0.2464333 0.0841 0.017763929 0.002494174 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177156 E001 2.024158 9.004217e-03 6.160207e-02 1.293183e-01 11 747401 747406 6 + 0.648 0.324 -1.640
ENSG00000177156 E002 3.380758 9.204589e-03 7.712364e-03 2.305640e-02 11 747407 747414 8 + 0.865 0.454 -1.779
ENSG00000177156 E003 3.900968 5.189339e-03 2.268352e-03 8.054816e-03 11 747415 747416 2 + 0.928 0.481 -1.882
ENSG00000177156 E004 3.900968 5.189339e-03 2.268352e-03 8.054816e-03 11 747417 747419 3 + 0.928 0.481 -1.882
ENSG00000177156 E005 5.566837 6.882936e-03 3.785370e-02 8.707437e-02 11 747420 747421 2 + 0.956 0.670 -1.129
ENSG00000177156 E006 9.798771 1.779172e-03 8.767317e-03 2.570095e-02 11 747422 747427 6 + 1.170 0.882 -1.058
ENSG00000177156 E007 214.419700 5.022049e-03 7.768501e-06 5.292431e-05 11 747428 747453 26 + 2.401 2.192 -0.698
ENSG00000177156 E008 335.680575 3.171003e-03 1.911944e-06 1.493473e-05 11 747454 747463 10 + 2.574 2.395 -0.596
ENSG00000177156 E009 1440.460867 9.082544e-04 2.607229e-08 2.971733e-07 11 747464 747578 115 + 3.154 3.047 -0.354
ENSG00000177156 E010 6.244087 4.795201e-02 5.312915e-02 1.147170e-01 11 752264 752473 210 + 1.009 0.690 -1.241
ENSG00000177156 E011 3.678387 4.312466e-03 2.197227e-01 3.500525e-01 11 755744 755878 135 + 0.748 0.554 -0.834
ENSG00000177156 E012 1946.050288 5.691113e-04 4.052960e-08 4.452170e-07 11 755879 756002 124 + 3.269 3.183 -0.285
ENSG00000177156 E013 8.128872 8.798890e-03 1.142486e-01 2.117379e-01 11 756003 756284 282 + 1.032 0.827 -0.773
ENSG00000177156 E014 10.219806 8.063497e-01 9.246674e-01 9.565674e-01 11 756359 756480 122 + 0.518 1.033 2.093
ENSG00000177156 E015 1436.567126 7.193544e-04 2.032211e-04 9.776444e-04 11 758950 759008 59 + 3.126 3.055 -0.235
ENSG00000177156 E016 1346.632932 1.369659e-03 5.826662e-01 7.069793e-01 11 759009 759057 49 + 3.043 3.042 -0.003
ENSG00000177156 E017 2131.894765 7.170318e-05 9.212947e-02 1.784426e-01 11 760122 760253 132 + 3.238 3.248 0.035
ENSG00000177156 E018 27.601709 8.366426e-03 1.653478e-12 3.907277e-11 11 760254 760965 712 + 1.741 1.181 -1.933
ENSG00000177156 E019 2521.767450 3.721549e-04 8.321165e-02 1.646013e-01 11 763344 763519 176 + 3.307 3.319 0.040
ENSG00000177156 E020 8.890361 2.001463e-03 9.417786e-03 2.732603e-02 11 763520 763520 1 + 1.135 0.838 -1.102
ENSG00000177156 E021 2677.396050 3.584965e-04 5.840207e-04 2.474953e-03 11 763747 763940 194 + 3.318 3.349 0.101
ENSG00000177156 E022 1041.785608 2.295936e-04 5.046717e-04 2.177623e-03 11 763941 763944 4 + 2.899 2.946 0.154
ENSG00000177156 E023 21.070497 2.420344e-02 8.248665e-04 3.348084e-03 11 763945 763981 37 + 1.521 1.156 -1.272
ENSG00000177156 E024 26.776917 2.836822e-02 3.471576e-03 1.164323e-02 11 763982 764063 82 + 1.590 1.276 -1.084
ENSG00000177156 E025 49.451423 4.786430e-03 1.432761e-03 5.416186e-03 11 764064 764287 224 + 1.776 1.572 -0.690
ENSG00000177156 E026 1810.313050 4.320887e-04 4.210015e-06 3.045846e-05 11 764288 764369 82 + 3.129 3.184 0.182
ENSG00000177156 E027 1522.607991 8.589874e-05 1.181477e-09 1.726529e-08 11 764370 764433 64 + 3.049 3.113 0.214
ENSG00000177156 E028 4.340379 3.799420e-03 3.673805e-04 1.647953e-03 11 764434 764446 13 + 0.000 0.748 12.179
ENSG00000177156 E029 1513.200721 2.855587e-04 9.468841e-09 1.173213e-07 11 764813 765012 200 + 3.041 3.110 0.231