ENSG00000177150

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402563 ENSG00000177150 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM210A protein_coding protein_coding 6.63519 2.314346 11.44649 0.1505435 0.8051196 2.301268 2.3354680 1.4175457 3.743558 0.15956759 0.25102136 1.394722 0.4458625 0.61513333 0.32813333 -0.28700000 1.744640e-03 6.871585e-14 FALSE TRUE
ENST00000585785 ENSG00000177150 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM210A protein_coding processed_transcript 6.63519 2.314346 11.44649 0.1505435 0.8051196 2.301268 0.6235057 0.1099386 0.750798 0.10993860 0.40964226 2.665218 0.0809250 0.04380000 0.06283333 0.01903333 6.746224e-01 6.871585e-14   FALSE
ENST00000588475 ENSG00000177150 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM210A protein_coding processed_transcript 6.63519 2.314346 11.44649 0.1505435 0.8051196 2.301268 0.9786459 0.1957760 1.735978 0.09877256 0.37316902 3.084888 0.1439250 0.08823333 0.15283333 0.06460000 6.148552e-01 6.871585e-14 FALSE TRUE
ENST00000589346 ENSG00000177150 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM210A protein_coding protein_coding 6.63519 2.314346 11.44649 0.1505435 0.8051196 2.301268 0.8964493 0.5025148 1.491922 0.09394811 0.05541938 1.551145 0.1454500 0.21533333 0.13220000 -0.08313333 1.568739e-01 6.871585e-14 FALSE FALSE
ENST00000592976 ENSG00000177150 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM210A protein_coding protein_coding 6.63519 2.314346 11.44649 0.1505435 0.8051196 2.301268 1.2521970 0.0000000 3.144912 0.00000000 0.43428093 8.301456 0.1142042 0.00000000 0.27283333 0.27283333 6.871585e-14 6.871585e-14 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177150 E001 0.2966881 0.0274424043 7.811631e-01   18 13663347 13663350 4 - 0.135 0.000 -9.634
ENSG00000177150 E002 159.8234179 0.0014425077 5.781167e-08 6.143629e-07 18 13663351 13665882 2532 - 2.109 2.271 0.541
ENSG00000177150 E003 31.5390541 0.0006585874 2.162402e-01 3.458832e-01 18 13665883 13666002 120 - 1.437 1.526 0.306
ENSG00000177150 E004 54.2496046 0.0004470707 6.433279e-04 2.692036e-03 18 13666003 13666230 228 - 1.639 1.813 0.589
ENSG00000177150 E005 63.1865297 0.0004244061 1.067502e-02 3.039392e-02 18 13666231 13666493 263 - 1.723 1.847 0.418
ENSG00000177150 E006 79.4129317 0.0003885630 3.053605e-05 1.813525e-04 18 13666494 13666713 220 - 1.900 1.718 -0.614
ENSG00000177150 E007 4.0965179 0.0040292425 1.087262e-01 2.036568e-01 18 13670871 13670968 98 - 0.592 0.834 0.999
ENSG00000177150 E008 34.8012933 0.0006740962 2.669319e-04 1.244967e-03 18 13671862 13671911 50 - 1.562 1.306 -0.885
ENSG00000177150 E009 30.2320746 0.0007067773 4.567981e-02 1.014478e-01 18 13671912 13671973 62 - 1.481 1.342 -0.483
ENSG00000177150 E010 87.6373046 0.0003533511 9.295392e-06 6.223658e-05 18 13681605 13682105 501 - 1.942 1.759 -0.617
ENSG00000177150 E011 2.5423069 0.0068688899 9.319107e-01 9.610914e-01 18 13687743 13687882 140 - 0.503 0.522 0.094
ENSG00000177150 E012 0.2944980 0.4550380789 1.000000e+00   18 13697547 13697674 128 - 0.135 0.000 -9.717
ENSG00000177150 E013 22.7428439 0.0008766840 2.043022e-05 1.264645e-04 18 13726329 13726663 335 - 1.408 1.013 -1.399