ENSG00000177042

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397510 ENSG00000177042 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM80 protein_coding protein_coding 34.76853 49.47515 24.08241 4.498276 0.2450589 -1.038417 22.822334 33.613138 13.625906 0.9953040 0.3690501 -1.3020438 0.64648333 0.68746667 0.5656000 -0.121866667 0.18049963 0.006624621 FALSE  
ENST00000488769 ENSG00000177042 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM80 protein_coding protein_coding 34.76853 49.47515 24.08241 4.498276 0.2450589 -1.038417 4.860565 4.713909 3.837766 1.0221058 0.1843424 -0.2959600 0.14744167 0.09313333 0.1593333 0.066200000 0.01726995 0.006624621    
ENST00000492023 ENSG00000177042 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM80 protein_coding retained_intron 34.76853 49.47515 24.08241 4.498276 0.2450589 -1.038417 2.295060 2.533742 1.918507 0.1733597 0.2056613 -0.3994681 0.07013333 0.05150000 0.0796000 0.028100000 0.06680155 0.006624621 FALSE  
MSTRG.4916.2 ENSG00000177042 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM80 protein_coding   34.76853 49.47515 24.08241 4.498276 0.2450589 -1.038417 2.783714 4.192692 2.180107 0.3978355 0.6354068 -0.9403125 0.08058333 0.08526667 0.0907000 0.005433333 1.00000000 0.006624621 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000177042 E001 14.884051 0.0018317708 5.443268e-01 6.748099e-01 11 695267 695534 268 + 1.182 1.132 -0.179
ENSG00000177042 E002 9.863274 0.0740783310 9.923314e-01 9.992835e-01 11 695535 695590 56 + 0.991 0.987 -0.015
ENSG00000177042 E003 9.629506 0.0021042786 3.909428e-01 5.348883e-01 11 695591 695642 52 + 0.895 1.004 0.406
ENSG00000177042 E004 21.070921 0.0676752143 2.897755e-01 4.305081e-01 11 695643 695795 153 + 1.181 1.326 0.512
ENSG00000177042 E005 14.538298 0.0344633501 9.146647e-01 9.499827e-01 11 695796 695801 6 + 1.137 1.137 -0.001
ENSG00000177042 E006 15.446819 0.0539973100 9.277277e-01 9.585400e-01 11 695802 695804 3 + 1.137 1.172 0.124
ENSG00000177042 E007 27.510284 0.0035913448 1.462413e-01 2.565655e-01 11 695805 695815 11 + 1.468 1.368 -0.346
ENSG00000177042 E008 44.890078 0.0010924721 1.879852e-02 4.889375e-02 11 695816 695822 7 + 1.690 1.565 -0.426
ENSG00000177042 E009 88.378992 0.0024520722 2.255531e-02 5.683361e-02 11 695823 695846 24 + 1.960 1.865 -0.320
ENSG00000177042 E010 124.817738 0.0003102216 2.906805e-02 7.013851e-02 11 698869 698888 20 + 2.090 2.023 -0.223
ENSG00000177042 E011 93.753945 0.0068687563 1.713919e-03 6.325429e-03 11 698889 700141 1253 + 2.033 1.873 -0.538
ENSG00000177042 E012 212.507250 0.0001800110 3.159181e-06 2.351659e-05 11 700142 700212 71 + 2.352 2.242 -0.368
ENSG00000177042 E013 170.468276 0.0008551492 1.012661e-05 6.720811e-05 11 700213 700235 23 + 2.269 2.142 -0.424
ENSG00000177042 E014 249.032663 0.0015570352 2.612855e-02 6.420367e-02 11 700615 700707 93 + 2.384 2.329 -0.184
ENSG00000177042 E015 47.694777 0.0046564951 7.667437e-03 2.294599e-02 11 700708 701127 420 + 1.735 1.580 -0.527
ENSG00000177042 E016 181.354836 0.0006155220 3.659170e-01 5.102336e-01 11 702945 703006 62 + 2.180 2.216 0.120
ENSG00000177042 E017 251.291663 0.0039538651 7.867046e-02 1.573750e-01 11 703007 703146 140 + 2.288 2.365 0.260
ENSG00000177042 E018 515.412609 0.0015300347 4.772979e-07 4.238430e-06 11 703147 703674 528 + 2.563 2.689 0.421
ENSG00000177042 E019 237.121222 0.0014203798 1.497374e-03 5.627539e-03 11 703675 703781 107 + 2.242 2.348 0.357
ENSG00000177042 E020 123.895097 0.0003016750 1.937301e-01 3.184685e-01 11 703782 703799 18 + 2.000 2.054 0.182
ENSG00000177042 E021 321.924202 0.0009055210 9.597368e-03 2.777203e-02 11 703800 704129 330 + 2.398 2.472 0.246
ENSG00000177042 E022 3.532756 0.0645737417 1.037017e-04 5.390581e-04 11 704442 705028 587 + 0.993 0.317 -3.039