ENSG00000176915

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357997 ENSG00000176915 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKLE2 protein_coding protein_coding 49.6406 35.22051 59.85112 0.06806309 0.8476377 0.7647936 21.555904 19.4588494 23.683893 1.19161654 0.4350896 0.2833477 0.44537500 0.552600000 0.39566667 -0.15693333 0.0056804322 1.300754e-23 FALSE TRUE
ENST00000538591 ENSG00000176915 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKLE2 protein_coding retained_intron 49.6406 35.22051 59.85112 0.06806309 0.8476377 0.7647936 3.910920 1.4008407 4.973865 0.24576340 0.4945458 1.8207099 0.07586667 0.039766667 0.08303333 0.04326667 0.0145073413 1.300754e-23 FALSE FALSE
ENST00000538766 ENSG00000176915 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKLE2 protein_coding protein_coding 49.6406 35.22051 59.85112 0.06806309 0.8476377 0.7647936 4.681298 2.4500900 6.330149 0.01308589 0.0625141 1.3658055 0.09431667 0.069566667 0.10580000 0.03623333 0.0009807457 1.300754e-23 FALSE FALSE
MSTRG.8352.10 ENSG00000176915 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKLE2 protein_coding   49.6406 35.22051 59.85112 0.06806309 0.8476377 0.7647936 9.196691 4.4160910 11.748031 1.44142954 0.6922503 1.4095415 0.17708750 0.125233333 0.19660000 0.07136667 0.3921265508 1.300754e-23 FALSE TRUE
MSTRG.8352.7 ENSG00000176915 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKLE2 protein_coding   49.6406 35.22051 59.85112 0.06806309 0.8476377 0.7647936 2.004292 0.3181954 3.648491 0.31819538 0.3301162 3.4786219 0.03864167 0.009033333 0.06086667 0.05183333 0.0751583740 1.300754e-23 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176915 E001 0.1482932 0.0413120588 3.939412e-01   12 132725391 132725460 70 - 0.000 0.135 11.224
ENSG00000176915 E002 0.1482932 0.0413120588 3.939412e-01   12 132725461 132725502 42 - 0.000 0.135 11.265
ENSG00000176915 E003 6.1996749 0.0047307375 3.826345e-03 1.265453e-02 12 132725503 132725667 165 - 0.651 1.021 1.449
ENSG00000176915 E004 8.5215546 0.0127992312 1.189037e-01 2.183700e-01 12 132725668 132725672 5 - 0.884 1.076 0.712
ENSG00000176915 E005 37.7331307 0.0087317997 9.473982e-05 4.972884e-04 12 132725673 132725713 41 - 1.428 1.717 0.987
ENSG00000176915 E006 44.4762389 0.0056763959 1.985626e-04 9.576652e-04 12 132725714 132725752 39 - 1.528 1.769 0.820
ENSG00000176915 E007 659.2925675 0.0051144843 1.625897e-04 8.031219e-04 12 132725753 132726583 831 - 2.746 2.886 0.466
ENSG00000176915 E008 243.9990103 0.0050936716 8.063447e-03 2.394163e-02 12 132726584 132726805 222 - 2.330 2.446 0.388
ENSG00000176915 E009 266.4874621 0.0010481598 1.609603e-02 4.295150e-02 12 132726806 132727132 327 - 2.396 2.463 0.222
ENSG00000176915 E010 146.2650419 0.0002203019 2.266708e-05 1.387467e-04 12 132727133 132727222 90 - 2.102 2.229 0.427
ENSG00000176915 E011 160.4502049 0.0002048608 1.253955e-06 1.020000e-05 12 132727223 132727285 63 - 2.135 2.275 0.466
ENSG00000176915 E012 219.7770599 0.0003710729 1.482331e-07 1.456703e-06 12 132727286 132727349 64 - 2.272 2.406 0.449
ENSG00000176915 E013 343.6323610 0.0002226125 1.135588e-11 2.342800e-10 12 132727350 132727443 94 - 2.465 2.603 0.459
ENSG00000176915 E014 413.2349850 0.0001372530 6.994235e-10 1.068837e-08 12 132728032 132728163 132 - 2.560 2.672 0.373
ENSG00000176915 E015 271.3067936 0.0001770341 3.410739e-05 2.000787e-04 12 132729679 132729722 44 - 2.387 2.480 0.311
ENSG00000176915 E016 823.1378417 0.0006269940 7.074621e-04 2.925706e-03 12 132729723 132730232 510 - 2.887 2.944 0.190
ENSG00000176915 E017 225.3359692 0.0028630060 3.219912e-01 4.652646e-01 12 132730233 132730270 38 - 2.337 2.375 0.128
ENSG00000176915 E018 13.8531746 0.0133690870 5.206813e-01 6.546381e-01 12 132730271 132730689 419 - 1.198 1.130 -0.243
ENSG00000176915 E019 37.1962073 0.0070243599 5.136037e-01 6.483946e-01 12 132730690 132732210 1521 - 1.553 1.601 0.164
ENSG00000176915 E020 11.1276386 0.0016783433 9.754598e-01 9.886833e-01 12 132733996 132734071 76 - 1.079 1.078 -0.004
ENSG00000176915 E021 351.5561980 0.0001427866 9.909543e-01 9.984752e-01 12 132734385 132734492 108 - 2.547 2.550 0.009
ENSG00000176915 E022 166.1649348 0.0025899926 4.871916e-01 6.248739e-01 12 132734493 132734496 4 - 2.235 2.211 -0.081
ENSG00000176915 E023 291.2532328 0.0002985819 3.791165e-02 8.718225e-02 12 132734497 132734575 79 - 2.488 2.445 -0.143
ENSG00000176915 E024 59.1537829 0.0004442230 4.679531e-12 1.027853e-10 12 132734576 132734967 392 - 1.910 1.579 -1.119
ENSG00000176915 E025 43.8647122 0.0010719882 4.265652e-07 3.825578e-06 12 132734968 132735226 259 - 1.764 1.481 -0.963
ENSG00000176915 E026 33.0773125 0.0084432621 1.406897e-06 1.131100e-05 12 132735227 132735405 179 - 1.673 1.295 -1.298
ENSG00000176915 E027 178.8357631 0.0003156562 7.370326e-02 1.494537e-01 12 132735406 132735406 1 - 2.278 2.232 -0.155
ENSG00000176915 E028 352.1755910 0.0002052311 8.078688e-02 1.607701e-01 12 132735407 132735512 106 - 2.565 2.534 -0.105
ENSG00000176915 E029 346.9477465 0.0003554517 7.596118e-03 2.276168e-02 12 132736893 132737042 150 - 2.567 2.514 -0.176
ENSG00000176915 E030 165.8204603 0.0047004410 1.359936e-01 2.424671e-01 12 132737043 132737065 23 - 2.251 2.187 -0.215
ENSG00000176915 E031 51.2533679 0.0173520692 4.598228e-01 5.999031e-01 12 132737066 132738907 1842 - 1.741 1.683 -0.197
ENSG00000176915 E032 235.7859789 0.0019725899 1.667145e-02 4.421700e-02 12 132741419 132741485 67 - 2.408 2.334 -0.248
ENSG00000176915 E033 6.4824808 0.0027693021 6.501980e-03 1.992786e-02 12 132741486 132741808 323 - 1.011 0.668 -1.342
ENSG00000176915 E034 8.5062956 0.0352959504 6.287045e-01 7.441979e-01 12 132741809 132741891 83 - 1.011 0.939 -0.268
ENSG00000176915 E035 14.0683948 0.0012686209 8.811722e-02 1.722618e-01 12 132741892 132742558 667 - 1.243 1.091 -0.542
ENSG00000176915 E036 250.7926351 0.0030127148 2.740024e-02 6.680601e-02 12 132743154 132743238 85 - 2.435 2.359 -0.254
ENSG00000176915 E037 198.0815566 0.0019401225 2.806546e-03 9.694265e-03 12 132743239 132743276 38 - 2.342 2.244 -0.327
ENSG00000176915 E038 369.0767782 0.0006347895 1.303034e-06 1.055842e-05 12 132747832 132748020 189 - 2.615 2.512 -0.345
ENSG00000176915 E039 376.8960581 0.0002619895 1.181020e-03 4.576880e-03 12 132748138 132748331 194 - 2.606 2.545 -0.202
ENSG00000176915 E040 0.0000000       12 132748887 132749027 141 -      
ENSG00000176915 E041 354.6241705 0.0002128139 2.717948e-09 3.722578e-08 12 132750643 132750849 207 - 2.602 2.487 -0.384
ENSG00000176915 E042 0.1817044 0.0412161430 3.914845e-01   12 132750850 132751334 485 - 0.000 0.135 11.269
ENSG00000176915 E043 549.0944705 0.0033520416 9.205569e-09 1.142686e-07 12 132754675 132755133 459 - 2.819 2.641 -0.591
ENSG00000176915 E044 4.9873092 0.0065072553 7.945665e-01 8.687546e-01 12 132755134 132756633 1500 - 0.773 0.811 0.152
ENSG00000176915 E045 21.7755910 0.0009133972 6.513073e-01 7.621920e-01 12 132756634 132756758 125 - 1.345 1.381 0.123
ENSG00000176915 E046 6.4410964 0.0025438878 8.183773e-01 8.852096e-01 12 132756759 132756761 3 - 0.884 0.858 -0.099
ENSG00000176915 E047 24.6301948 0.0058961904 2.681951e-01 4.066326e-01 12 132756762 132761617 4856 - 1.357 1.444 0.303
ENSG00000176915 E048 98.5884629 0.0009393934 1.505520e-16 6.339547e-15 12 132761618 132761835 218 - 2.127 1.801 -1.095