ENSG00000176890

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323274 ENSG00000176890 HEK293_OSMI2_2hA HEK293_TMG_2hB TYMS protein_coding protein_coding 142.1265 171.1234 153.7566 15.68795 3.411927 -0.1543789 123.17085 134.88703 142.8052 9.397978 3.312084 0.08229127 0.8667333 0.7912333 0.9288 0.1375667 1.571878e-09 1.5853e-60 FALSE TRUE
ENST00000581920 ENSG00000176890 HEK293_OSMI2_2hA HEK293_TMG_2hB TYMS protein_coding processed_transcript 142.1265 171.1234 153.7566 15.68795 3.411927 -0.1543789 11.51677 30.74204 0.0000 6.465683 0.000000 -11.58646620 0.0807000 0.1760667 0.0000 -0.1760667 1.585300e-60 1.5853e-60 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176890 E001 2.149753 6.909330e-03 2.325921e-03 8.230852e-03 18 657599 657603 5 + 0.716 0.205 -2.798
ENSG00000176890 E002 27.983502 7.990173e-04 1.138186e-15 4.266440e-14 18 657604 657652 49 + 1.690 1.146 -1.885
ENSG00000176890 E003 45.580100 3.280490e-02 3.399330e-10 5.477528e-09 18 657653 657664 12 + 1.930 1.260 -2.291
ENSG00000176890 E004 221.956240 4.559477e-02 4.553808e-08 4.952383e-07 18 657665 657742 78 + 2.591 1.993 -1.996
ENSG00000176890 E005 766.916122 3.734569e-03 1.241047e-10 2.156403e-09 18 657743 657947 205 + 2.988 2.781 -0.690
ENSG00000176890 E006 1.919671 1.005041e-02 7.873943e-01 8.638442e-01 18 657948 658169 222 + 0.492 0.449 -0.214
ENSG00000176890 E007 1.255549 2.742657e-02 1.110080e-01 2.070271e-01 18 658264 658748 485 + 0.492 0.205 -1.797
ENSG00000176890 E008 836.282803 7.273028e-04 9.419269e-05 4.946918e-04 18 659641 659714 74 + 2.958 2.889 -0.227
ENSG00000176890 E009 1650.055855 7.564176e-05 5.371834e-02 1.157610e-01 18 662146 662320 175 + 3.224 3.210 -0.049
ENSG00000176890 E010 0.147249 4.319247e-02 4.317678e-01   18 667721 667752 32 + 0.130 0.000 -9.437
ENSG00000176890 E011 1421.427642 2.060061e-04 8.013886e-02 1.597591e-01 18 669072 669173 102 + 3.139 3.159 0.068
ENSG00000176890 E012 24.465924 2.806180e-02 4.637182e-02 1.027125e-01 18 669174 669464 291 + 1.518 1.297 -0.764
ENSG00000176890 E013 1948.208041 1.922087e-04 3.073455e-03 1.048280e-02 18 670692 670867 176 + 3.270 3.299 0.096
ENSG00000176890 E014 1416.253136 6.990306e-04 7.621912e-02 1.534542e-01 18 671380 671451 72 + 3.133 3.158 0.084
ENSG00000176890 E015 30.131740 8.753866e-04 4.376980e-05 2.500696e-04 18 671799 671906 108 + 1.620 1.363 -0.882
ENSG00000176890 E016 3056.237568 1.153007e-03 3.003491e-14 9.208649e-13 18 672860 673578 719 + 3.418 3.520 0.338