ENSG00000176834

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321694 ENSG00000176834 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10 protein_coding processed_transcript 10.53962 12.88647 11.54482 0.2807502 0.6959779 -0.1584816 0.9877674 1.2562318 1.0012600 0.29010725 0.40847206 -0.3243875 0.09128333 0.09686667 0.08290000 -0.013966667 8.560011e-01 9.057316e-07    
ENST00000359236 ENSG00000176834 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10 protein_coding protein_coding 10.53962 12.88647 11.54482 0.2807502 0.6959779 -0.1584816 1.8389378 1.6880189 2.1660607 0.11202334 0.04825530 0.3578663 0.17985833 0.13113333 0.18860000 0.057466667 8.092717e-02 9.057316e-07 FALSE  
ENST00000539956 ENSG00000176834 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10 protein_coding processed_transcript 10.53962 12.88647 11.54482 0.2807502 0.6959779 -0.1584816 0.6017525 0.7207452 0.6261301 0.17364859 0.28136861 -0.2000467 0.05762917 0.05593333 0.05206667 -0.003866667 9.140262e-01 9.057316e-07 TRUE  
ENST00000545259 ENSG00000176834 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10 protein_coding retained_intron 10.53962 12.88647 11.54482 0.2807502 0.6959779 -0.1584816 0.4141314 0.1558344 0.8829277 0.08788310 0.10824313 2.4288005 0.04082500 0.01190000 0.07726667 0.065366667 1.046786e-02 9.057316e-07 FALSE  
ENST00000612851 ENSG00000176834 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10 protein_coding retained_intron 10.53962 12.88647 11.54482 0.2807502 0.6959779 -0.1584816 0.8484343 1.5281973 0.4213970 0.03712787 0.03460576 -1.8341525 0.07838750 0.11860000 0.03683333 -0.081766667 9.057316e-07 9.057316e-07 TRUE  
ENST00000621133 ENSG00000176834 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10 protein_coding processed_transcript 10.53962 12.88647 11.54482 0.2807502 0.6959779 -0.1584816 2.1545834 3.2898131 2.0053936 0.43175087 0.15242676 -0.7113227 0.20070417 0.25620000 0.17660000 -0.079600000 3.598721e-01 9.057316e-07    
MSTRG.8111.13 ENSG00000176834 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10 protein_coding   10.53962 12.88647 11.54482 0.2807502 0.6959779 -0.1584816 1.7165915 1.7101520 2.0451002 0.13526172 0.10040690 0.2566727 0.16651667 0.13246667 0.17920000 0.046733333 3.367556e-01 9.057316e-07 TRUE  
MSTRG.8111.15 ENSG00000176834 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIG10 protein_coding   10.53962 12.88647 11.54482 0.2807502 0.6959779 -0.1584816 0.7593501 0.9640376 0.7810316 0.21946032 0.25882379 -0.3002420 0.07041250 0.07543333 0.06550000 -0.009933333 8.916599e-01 9.057316e-07 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176834 E001 156.9796397 0.0005545384 5.553094e-09 7.188363e-08 12 118063593 118066694 3102 - 2.278 2.128 -0.502
ENSG00000176834 E002 26.3162940 0.0116436385 5.538218e-01 6.829032e-01 12 118068377 118068597 221 - 1.461 1.418 -0.146
ENSG00000176834 E003 1.7735559 0.0085045555 6.851894e-02 1.409154e-01 12 118070953 118071051 99 - 0.587 0.276 -1.686
ENSG00000176834 E004 8.0057127 0.0022390336 8.082079e-01 8.781353e-01 12 118071052 118071067 16 - 0.965 0.939 -0.095
ENSG00000176834 E005 3.1878954 0.0053484476 4.309231e-03 1.401062e-02 12 118071068 118071358 291 - 0.827 0.394 -1.951
ENSG00000176834 E006 21.1148669 0.0009937250 7.182479e-02 1.463810e-01 12 118071359 118071469 111 - 1.415 1.287 -0.448
ENSG00000176834 E007 37.3662681 0.0006403182 5.528982e-04 2.357526e-03 12 118073699 118073992 294 - 1.680 1.490 -0.647
ENSG00000176834 E008 14.5389988 0.0012564019 9.611055e-01 9.795143e-01 12 118079346 118079398 53 - 1.185 1.182 -0.009
ENSG00000176834 E009 16.5632585 0.0011810373 5.785231e-01 7.035980e-01 12 118079399 118079453 55 - 1.259 1.215 -0.156
ENSG00000176834 E010 24.2332932 0.0008162696 2.879590e-01 4.284951e-01 12 118079454 118079606 153 - 1.351 1.427 0.264
ENSG00000176834 E011 10.4162773 0.0102122264 1.295948e-01 2.335865e-01 12 118082127 118082151 25 - 0.930 1.101 0.630
ENSG00000176834 E012 21.2813434 0.0009158525 1.628867e-01 2.789056e-01 12 118082152 118082277 126 - 1.276 1.382 0.370
ENSG00000176834 E013 20.6194410 0.0011121828 3.312628e-01 4.748650e-01 12 118082278 118082429 152 - 1.365 1.294 -0.248
ENSG00000176834 E014 9.6852381 0.0017736590 5.471688e-01 6.772430e-01 12 118095533 118095545 13 - 1.056 0.995 -0.223
ENSG00000176834 E015 17.3812332 0.0010715620 1.947967e-02 5.037286e-02 12 118095546 118095621 76 - 1.358 1.174 -0.648
ENSG00000176834 E016 16.0234793 0.0011771291 5.796048e-04 2.458619e-03 12 118095622 118095678 57 - 1.372 1.088 -1.001
ENSG00000176834 E017 22.0712171 0.0011428007 1.288338e-04 6.538284e-04 12 118095679 118095814 136 - 1.497 1.223 -0.953
ENSG00000176834 E018 15.3896929 0.0026809590 6.776491e-08 7.113175e-07 12 118101605 118101899 295 - 0.804 1.349 1.993
ENSG00000176834 E019 26.2022828 0.0008264428 8.552987e-12 1.801620e-10 12 118101900 118102267 368 - 1.042 1.570 1.852
ENSG00000176834 E020 24.5374259 0.0033391741 4.369590e-08 4.768192e-07 12 118102268 118102838 571 - 1.095 1.536 1.545
ENSG00000176834 E021 7.5285471 0.0202661744 3.658299e-02 8.467883e-02 12 118102839 118102988 150 - 0.724 1.010 1.105
ENSG00000176834 E022 20.1845585 0.0322401272 7.041718e-01 8.027731e-01 12 118102989 118103170 182 - 1.285 1.328 0.151
ENSG00000176834 E023 0.7727888 0.0324571303 8.230734e-01 8.884837e-01 12 118103171 118103176 6 - 0.234 0.275 0.309
ENSG00000176834 E024 25.1410434 0.0008147887 8.672115e-02 1.701559e-01 12 118103593 118104011 419 - 1.330 1.451 0.419
ENSG00000176834 E025 0.2965864 0.1445954789 2.948976e-01   12 118114350 118114412 63 - 0.000 0.200 9.471
ENSG00000176834 E026 6.5988885 0.0026779375 5.145761e-01 6.493106e-01 12 118117036 118117039 4 - 0.827 0.909 0.313
ENSG00000176834 E027 46.4414481 0.0006104510 1.058538e-04 5.489349e-04 12 118117046 118117648 603 - 1.539 1.744 0.697
ENSG00000176834 E028 8.1953741 0.0022991647 2.024208e-04 9.742644e-04 12 118117649 118117666 18 - 0.625 1.088 1.807
ENSG00000176834 E029 9.0985869 0.0177902076 2.325400e-03 8.229318e-03 12 118117667 118117686 20 - 0.723 1.119 1.503
ENSG00000176834 E030 30.9315724 0.0010184129 6.224474e-01 7.392412e-01 12 118117687 118117882 196 - 1.482 1.514 0.111
ENSG00000176834 E031 6.0075358 0.0472021210 2.570588e-01 3.941057e-01 12 118121029 118121117 89 - 0.723 0.895 0.677
ENSG00000176834 E032 5.7713314 0.0272554618 9.891948e-01 9.972899e-01 12 118121501 118121618 118 - 0.827 0.822 -0.021
ENSG00000176834 E033 40.9168201 0.0005642513 9.452517e-01 9.696454e-01 12 118126481 118126663 183 - 1.613 1.619 0.019
ENSG00000176834 E034 12.7622752 0.0129694718 2.847314e-01 4.249773e-01 12 118126664 118126670 7 - 1.195 1.087 -0.384
ENSG00000176834 E035 7.7599408 0.0022991590 9.279492e-01 9.586428e-01 12 118135639 118135742 104 - 0.948 0.939 -0.031
ENSG00000176834 E036 20.7329608 0.0063345666 9.597713e-01 9.787051e-01 12 118135857 118136083 227 - 1.330 1.336 0.022