ENSG00000176783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319449 ENSG00000176783 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY1 protein_coding protein_coding 36.65997 32.49352 40.41029 0.2237174 1.305512 0.3144838 10.638021 8.095711 16.564427 1.5485931 0.6501255 1.03194832 0.28819167 0.24850000 0.41166667 0.163166667 9.514079e-02 7.719203e-05 FALSE TRUE
ENST00000393438 ENSG00000176783 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY1 protein_coding protein_coding 36.65997 32.49352 40.41029 0.2237174 1.305512 0.3144838 6.121014 7.746552 4.097072 1.4775470 0.3336725 -0.91730537 0.16613750 0.23903333 0.10196667 -0.137066667 3.263429e-02 7.719203e-05 FALSE TRUE
ENST00000437570 ENSG00000176783 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY1 protein_coding protein_coding 36.65997 32.49352 40.41029 0.2237174 1.305512 0.3144838 6.723541 5.244252 6.670464 0.3189081 0.8172121 0.34646289 0.18046667 0.16150000 0.16416667 0.002666667 1.000000e+00 7.719203e-05 FALSE TRUE
ENST00000502531 ENSG00000176783 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY1 protein_coding retained_intron 36.65997 32.49352 40.41029 0.2237174 1.305512 0.3144838 1.857157 1.407594 1.502885 0.3450794 0.2597885 0.09385768 0.05348333 0.04316667 0.03723333 -0.005933333 8.914961e-01 7.719203e-05 FALSE TRUE
ENST00000503583 ENSG00000176783 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY1 protein_coding retained_intron 36.65997 32.49352 40.41029 0.2237174 1.305512 0.3144838 2.291223 2.497766 1.384029 0.1294648 0.1123560 -0.84714221 0.06695000 0.07690000 0.03433333 -0.042566667 7.719203e-05 7.719203e-05 FALSE FALSE
ENST00000508609 ENSG00000176783 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY1 protein_coding protein_coding 36.65997 32.49352 40.41029 0.2237174 1.305512 0.3144838 3.806212 2.589836 5.302689 0.2503822 1.2138979 1.03102148 0.09882083 0.07966667 0.12953333 0.049866667 3.665282e-01 7.719203e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176783 E001 58.960686 0.0158288382 2.712831e-04 1.262839e-03 5 179550554 179550712 159 + 1.892 1.619 -0.924
ENSG00000176783 E002 56.215671 0.0243243588 1.639232e-03 6.087020e-03 5 179550713 179550835 123 + 1.871 1.599 -0.920
ENSG00000176783 E003 13.611609 0.0016035340 3.657254e-10 5.868676e-09 5 179550836 179550837 2 + 1.375 0.744 -2.320
ENSG00000176783 E004 30.688237 0.0105081110 1.056707e-04 5.480904e-04 5 179550838 179550879 42 + 1.625 1.317 -1.062
ENSG00000176783 E005 2.597753 0.0320673334 3.538473e-01 4.981186e-01 5 179555650 179555790 141 + 0.637 0.489 -0.677
ENSG00000176783 E006 1.434120 0.0118213104 1.324932e-01 2.375496e-01 5 179559692 179559740 49 + 0.494 0.230 -1.598
ENSG00000176783 E007 27.771710 0.0009160221 5.874865e-01 7.107622e-01 5 179559741 179559835 95 + 1.474 1.446 -0.096
ENSG00000176783 E008 43.014530 0.0011735098 2.832680e-01 4.233534e-01 5 179559836 179560024 189 + 1.670 1.619 -0.173
ENSG00000176783 E009 165.631117 0.0042379123 2.522190e-03 8.828759e-03 5 179560025 179560198 174 + 2.277 2.161 -0.390
ENSG00000176783 E010 142.865930 0.0074526451 4.877255e-02 1.069782e-01 5 179562547 179562630 84 + 2.201 2.108 -0.310
ENSG00000176783 E011 104.541443 0.0002986733 3.808916e-02 8.751864e-02 5 179562631 179562664 34 + 2.053 1.989 -0.215
ENSG00000176783 E012 4.135098 0.0038624700 9.113836e-01 9.477379e-01 5 179562665 179562922 258 + 0.693 0.716 0.093
ENSG00000176783 E013 123.456868 0.0002862549 3.889210e-02 8.898110e-02 5 179567461 179567509 49 + 2.124 2.066 -0.194
ENSG00000176783 E014 134.574127 0.0003275946 3.081096e-02 7.354777e-02 5 179567510 179567562 53 + 2.161 2.102 -0.196
ENSG00000176783 E015 202.379215 0.0016979501 3.155699e-02 7.499030e-02 5 179569302 179569425 124 + 2.337 2.277 -0.200
ENSG00000176783 E016 122.761272 0.0012331871 1.729639e-02 4.559717e-02 5 179577075 179577112 38 + 2.130 2.053 -0.258
ENSG00000176783 E017 126.185743 0.0011172178 7.895473e-02 1.578503e-01 5 179577113 179577136 24 + 2.131 2.078 -0.178
ENSG00000176783 E018 136.490469 0.0002731082 8.356282e-04 3.386268e-03 5 179580947 179581012 66 + 2.184 2.090 -0.314
ENSG00000176783 E019 181.584920 0.0017875930 1.512206e-02 4.076306e-02 5 179585796 179585865 70 + 2.296 2.224 -0.238
ENSG00000176783 E020 15.130174 0.0011745524 7.758335e-01 8.556246e-01 5 179586331 179586475 145 + 1.191 1.224 0.114
ENSG00000176783 E021 8.429694 0.0019968952 4.388228e-01 5.806683e-01 5 179586476 179586563 88 + 1.017 0.939 -0.287
ENSG00000176783 E022 2.756187 0.0058943986 3.324162e-01 4.760708e-01 5 179589363 179589545 183 + 0.494 0.653 0.721
ENSG00000176783 E023 257.109223 0.0002165133 4.819194e-03 1.542798e-02 5 179589546 179589647 102 + 2.438 2.383 -0.183
ENSG00000176783 E024 2.601088 0.0786861758 5.754943e-01 7.010936e-01 5 179590861 179590958 98 + 0.606 0.492 -0.528
ENSG00000176783 E025 295.187910 0.0024267850 2.446840e-01 3.796760e-01 5 179591625 179591741 117 + 2.484 2.457 -0.093
ENSG00000176783 E026 316.567960 0.0003551804 2.626999e-01 4.004966e-01 5 179593478 179593645 168 + 2.484 2.515 0.104
ENSG00000176783 E027 206.671456 0.0001877676 6.444685e-05 3.531649e-04 5 179594866 179594963 98 + 2.260 2.366 0.357
ENSG00000176783 E028 1.397398 0.0098132123 6.105229e-01 7.298459e-01 5 179596560 179596561 2 + 0.345 0.439 0.527
ENSG00000176783 E029 196.096306 0.0002656043 4.622090e-05 2.626398e-04 5 179596562 179596681 120 + 2.234 2.347 0.376
ENSG00000176783 E030 223.622272 0.0035986984 3.685280e-02 8.518781e-02 5 179598692 179598821 130 + 2.308 2.394 0.288
ENSG00000176783 E031 223.164208 0.0042687827 1.113079e-01 2.074691e-01 5 179601892 179601986 95 + 2.315 2.386 0.238
ENSG00000176783 E032 10.122996 0.0055174083 4.825523e-01 6.206884e-01 5 179601987 179602571 585 + 1.004 1.086 0.299
ENSG00000176783 E033 184.535702 0.0060116866 3.613015e-01 5.056989e-01 5 179605876 179605924 49 + 2.244 2.294 0.170
ENSG00000176783 E034 31.158430 0.0195136858 4.516354e-01 5.925644e-01 5 179605925 179606584 660 + 1.460 1.537 0.264
ENSG00000176783 E035 26.351400 0.0007742562 7.574198e-04 3.105998e-03 5 179606903 179607265 363 + 1.296 1.534 0.824
ENSG00000176783 E036 18.550979 0.0009853184 1.104455e-03 4.318055e-03 5 179607266 179607485 220 + 1.137 1.406 0.944
ENSG00000176783 E037 11.700418 0.0046759149 1.477424e-04 7.373966e-04 5 179607486 179607581 96 + 0.867 1.266 1.455
ENSG00000176783 E038 219.880653 0.0071526930 8.111680e-02 1.612894e-01 5 179607582 179607659 78 + 2.297 2.386 0.299
ENSG00000176783 E039 15.849137 0.0020015601 1.959117e-01 3.211131e-01 5 179608285 179608465 181 + 1.156 1.275 0.421
ENSG00000176783 E040 554.426841 0.0024037213 3.813452e-07 3.452389e-06 5 179609376 179610012 637 + 2.668 2.808 0.465